2003
Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret
Monckton J, McCormick D. Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret. Thalamus & Related Systems 2003, 2: 239-252. DOI: 10.1016/s1472-9288(03)00022-0.Peer-Reviewed Original ResearchApplication of serotoninThalamocortical neuronsLow-threshold Ca2Pulvinar neuronsThreshold Ca2Hyperpolarization-activated cation currentSingle spike activityBasic electrophysiological propertiesDistinct firing modesProminent hyperpolarizationMembrane potassium conductanceSerotoninergic propertiesSignificant species-dependent differencesSpike activityCation currentMonkey neuronsElectrophysiological propertiesPotassium conductanceNeuronsPharmacological propertiesSerotoninMonkeysCatsPulvinarSpecies-dependent differences
1992
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeurons
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism