2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarization
2003
Turning on and off recurrent balanced cortical activity
Shu Y, Hasenstaub A, McCormick D. Turning on and off recurrent balanced cortical activity. Nature 2003, 423: 288-293. PMID: 12748642, DOI: 10.1038/nature01616.Peer-Reviewed Original ResearchConceptsCerebral cortexLocal cortical circuitsCortical neuronsNeuronal excitabilitySynaptic inputsCortical circuitsSpontaneous activityCortical activitySynaptic connectionsRecurrent excitationCortical organizationCortexNeuronsLocal recurrent connectionsRecurrent activitySelf-sustained activityHypothesized roleInhibitionVast majorityActivityExcitabilityExcitatory