1993
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine
1986
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick D, Prince D. Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro. The Journal Of Physiology 1986, 375: 169-194. PMID: 2879035, PMCID: PMC1182754, DOI: 10.1113/jphysiol.1986.sp016112.Peer-Reviewed Original ResearchConceptsNon-pyramidal cellsSlow excitatory responsesPyramidal neuronesMechanism of actionAction potentialsExcitatory responsesInhibitory responsesACh applicationGuinea pig cerebral cortexLayer V pyramidal cellsInhibitory post-synaptic potentialsGABAergic synaptic transmissionRelease of GABAShort-latency excitationSlow depolarizing responseApparent input resistanceACh-induced hyperpolarizationApplication of acetylcholineGamma-aminobutyric acidGuinea pig neocortexPost-synaptic potentialsAverage reversal potentialBarrages of excitatoryMinimum onset latencyAction potential generation