1992
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1989
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicuculline