2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
1993
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slices