1993
Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function
McCormick D. Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function. Progress In Brain Research 1993, 98: 303-308. PMID: 8248519, DOI: 10.1016/s0079-6123(08)62412-7.Peer-Reviewed Original ResearchConceptsCholinergic neuronsCerebral cortexNicotinic receptorsForebrain activityAction of acetylcholinePost-synaptic responsesAbnormal neuronal functionNicotinic typeCholinergic pathwaysBasal forebrainCholinergic receptorsMuscarinic receptorsCholinergic systemMammalian CNSPhasic responseModulatory controlNeuronal functionAlzheimer's diseaseDistinct subtypesReceptor activationProlonged inhibitionFiring patternsPharmacological propertiesAcetylcholineProlonged changes
1992
Neurotransmitter Actions in the Thalamus and Cerebral Cortex
McCormick D. Neurotransmitter Actions in the Thalamus and Cerebral Cortex. Journal Of Clinical Neurophysiology 1992, 9: 212-223. PMID: 1350591, DOI: 10.1097/00004691-199204010-00004.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral cortexThalamocortical activityInhibitory amino acidsSleep-wake cyclePostsynaptic actionsCortical neuronsNeurotransmitter actionEpileptic seizuresSynaptic informationTransmitter actionThalamusNorepinephrineAcetylcholineCortexNeurotransmittersSeizuresExcitabilityNeocortexHistamineExcitatoryState of activityNeuronsActivity
1989
Convergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick D, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8098-8102. PMID: 2573061, PMCID: PMC298222, DOI: 10.1073/pnas.86.20.8098.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexPostsynaptic actionsCerebral cortexPutative neurotransmittersMuscarinic receptor agonistApplication of acetylcholineCortical pyramidal cellsGamma-aminobutyric acidDistinct potassium currentsSpecific anatomical connectionsSpike frequency adaptationPostsynaptic receptorsReceptor agonistPyramidal cellsNeurotransmitter systemsM-currentNeuronal firingNeurotransmitter actionPotassium currentCortical activityAnatomical connectionsSerotoninNeurotransmittersNorepinephrineAcetylcholineCholinergic and noradrenergic modulation of thalamocortical processing
McCormick D. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends In Neurosciences 1989, 12: 215-221. PMID: 2473557, DOI: 10.1016/0166-2236(89)90125-2.Peer-Reviewed Original ResearchConceptsThalamocortical processingPeriods of drowsinessState of excitabilityModulatory neurotransmitter systemsNeuronal responsivenessNoradrenergic componentThalamocortical rhythmsCortical neuronsNeurotransmitter systemsNoradrenergic modulationSynaptic inputsNeuronal activityPotassium currentSynchronized sleepMarked increaseRhythmic oscillationsRhythmNorepinephrineAcetylcholineExcitabilitySleepNeuronsDrowsiness
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism