Rajita Sinha, PhD
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of NeuroscienceCards
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
About
Titles
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience
Deputy Chair of Psychiatry for Psychology, Psychiatry; Director, Yale Interdisciplinary Stress Center; Chief, Psychology Section in Psychiatry
Biography
Rajita Sinha, Ph.D. is the Foundations Fund Endowed Professor in Psychiatry, and Professor in Neuroscience and in Child Study at the Yale University School of Medicine. She is a licensed Clinical Psychologist and Clinical Neuroscientist, Deputy Chair of Psychiatry for Psychology and Chief of the Psychology Section in Psychiatry. She is the founding director of the Yale Interdisciplinary Stress Center that focuses on understanding the neurobiology and psychology of stress, trauma and resilient versus vulnerable biobehavioral coping mechanisms that promote neuropsychiatric diseases such as alcohol use disorders, substance use disorders, chronic pain, PTSD and other chronic diseases. She has developed novel stress, pain and craving provocation paradigms to understand mechanisms that drive these states and related pathologies and their impact on clinical addiction outcomes in alcohol use disorder, substance use disorders and related conditions. Her lab also develops and tests novel pharmacologic and integrative behavioral approaches to address chronic stress and addiction relapse risk to improve addiction treatment outcomes. These objectives are being accomplished through a series of NIH funded research projects and she has published widely on these topics. She is the 2020 recipient of the Research Society on Alcoholism's Distinguished Researcher Award, and the 2020 recipient of the James Tharpe Award for outstanding contributions to Addiction Research. She has served on many NIH special emphasis panels, review committees and workshops, presented at numerous national and international conferences, and her work is widely cited.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Connecticut Mental Health Center
- Diabetes Research Center
- Division of Addictions
- Division of Substance Abuse
- MR Core
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- South Asian Studies
- Stress & Addiction Clinical Research Program
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Stress Center
- Yale Ventures
- Yale-Drug use, Addiction, and HIV prevention Research Scholars (DAHRS)
Education & Training
- PhD
- Yale University, Psychology/Clinical Respecialization (1992)
- PhD
- Oklahoma University Health Sciences Center (1990)
Research
Overview
Medical Research Interests
ORCID
0000-0003-3012-4349
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Dongju Seo, PhD
Verica Milivojevic, PhD
Stephanie Wemm, PhD
Nia Fogelman, PhD
Todd Constable, PhD
Chiang-Shan Ray Li, MD, PhD
Stress, Psychological
Substance-Related Disorders
Chronic Disease
Neurobiology
Publications
2025
W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study
Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.Peer-Reviewed Original ResearchM125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder
Fogelman N, McGowan C, Wemm S, Tate M, Hermes G, Sinha R, Wemm S. M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder. Drug And Alcohol Dependence 2025, 267: 111719. DOI: 10.1016/j.drugalcdep.2024.111719.Peer-Reviewed Original ResearchPregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder
Milivojevic V, Sakmar E, Fogelman N, Hermes G, Sinha R. Pregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder. Drug And Alcohol Dependence 2025, 267: 112227. DOI: 10.1016/j.drugalcdep.2024.112227.Peer-Reviewed Original ResearchRole of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery
Seo D, Choi J, Sinha R, De Aquiar R. Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery. Drug And Alcohol Dependence 2025, 267: 112197. DOI: 10.1016/j.drugalcdep.2024.112197.Peer-Reviewed Original ResearchW33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD
Conway R, Pearlman M, Sinha R, Wemm S, Conway R. W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD. Drug And Alcohol Dependence 2025, 267: 111975. DOI: 10.1016/j.drugalcdep.2024.111975.Peer-Reviewed Original ResearchPositive affect amplifies integration within episodic memories in the laboratory and the real world.
Pratt J, Wemm S, Harris B, Huang Y, Sinha R, Goldfarb E. Positive affect amplifies integration within episodic memories in the laboratory and the real world. Learning & Memory 2025, 32: a053971. PMID: 39870487, PMCID: PMC11801478, DOI: 10.1101/lm.053971.124.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPositive eventsReal worldEpisodic memoryEmotional eventsConsistent with past findingsTime of retrievalImpact of emotionsParticipants' emotional responsesMemory accuracyAssess memoryPositive affectExperiment 1Experiment 2Memory integrationEmotional responsesEmotional statesMemoryMemory structureNegative experiencesMemory featuresLaboratory environmentAccuracySmartphonePregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic functionStress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response
Wemm S, Pearlman M, Sinha R. Stress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response. 2025, 145-162. DOI: 10.4135/9781529673913.n10.Peer-Reviewed Original Research
2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposureStability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchConceptsCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biology
Clinical Trials
Current Trials
Prazosin for Alcohol Use Disorder
HIC ID2000029805RolePrincipal InvestigatorPrimary Completion Date01/15/2026Recruiting ParticipantsGenderBothAge18 years - 70 yearsGLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
HIC ID2000027868RoleSub InvestigatorPrimary Completion Date06/30/2025Recruiting ParticipantsGenderBothAge18 years - 55 yearsCharacterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
HIC ID2000026626RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18 years - 50 years
News & Links
Media
- Higher the cumulative stress exposure, greater the reduction in brain volume in specific regions of the medial, anterior and lateral prefrontal cortex, and in the insula and striatum (shown in yellow blobs). These are regions involved in emotion, reward and motivation processing. Ansel et al., Biological Psychiatry 2011.
News
- March 14, 2025Source: Time
Why Your Cortisol Levels Shouldn’t Stress You Out
- December 27, 2024Source: USA Today
The holidays can be stressful. Tips for managing the season (and all year long).
- October 29, 2024Source: National Public Radio
Feeling Stressed? Here's What is Actually Happening
- August 06, 2024Source: The New York Times
Can Stress Really Give You a Round ‘Cortisol Face?’
Related Links
- AARP Bulletin Today on how stress can impact your health - Published 5/1/2009
- Even in the healthy, stress causes brain to shrink, Yale study shows
- Gender in the mix: Under stress, men crave alcohol more than women do - The Los Angeles Times, Health section (5/19/08)
- Link between stress and alcohol craving in alcoholics struggling to achieve recovery - Neuropsychopharmacology, 6/18/08
- Yale Stress Center