Keck MS & Proteomics Resource Publications

260. Vidyadhara, D.J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Ribaudo, J., Shashaank N., Gupta, J., Lam, T., Sames, D., Greene, L.E., Sulzer, D., Chandra, S.S. (2023) Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-mediated Parkinson’s Disease. Cell Reports 42(3): 112231 (PMCID: PMC10127800).

259. Shi, G., Song, C., Robles, J., Salichos, L., Lou, H., Lam, T.T., Gerstein, M.,Turk, B.E. (2023) Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors. Science Signaling 16 (767), eabm5518 (PMCID: PMC9995140).

258. Robert, S., Reeves, B., Kiziltug, E., Duy, P., Karimy, J., Mansuri, M., Marlier, A., Allington, G., Greenberg, A., DeSpenza, T., Singh, A., Zeng, X., Mekbib, K., Kundishora,.,Nelson-Williams, C., Zhang, J., Lam, T.T., Wilson, R., Butler, W., Diluna, M., Feinberg, P., Schafer, D., Movahedi, K., Tannenbaum, A., Koundal, S., Chen, X., Benveniste, H., Limbrick, D., Schiff, S., Carter, B., Gunel, M., Simard, J., Lifton, R.P., Alper, S., Delpire, E., Kahle, K.T. (2023) The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 186(4): 764-785 (PMID: 36803604, PMCID: PMC10069664 available on 2024-02-16).

257. Onuchic, L., Padovano, V., Schena, G., Rajendran, V., Dong, K., Shi, X., Pandya, R., Rai, V., Gresko, N., Ahmed, O., Lam, T.T., Wang, W., Shen, H., Somlo, S., Caplan, M.J. (2023) The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 14(1):1790 (PMCID: PMC10063565).

256. Misra, S., Khan, E., Lam, T. T., Mazumder, R., Gururangan, K., Hickman, L. B., Goswami, V., Funaro, M. C., Eldem, E., Sansing, L. H., Sico, J. J., Quinn, T. J., Liebeskind, D., Montaner, J., Kwan, P., Mishra, N. K. (2023) The common pathways of Epileptogenesis in patients With Epilepsy Post-Brain Injury: Findings from a systematic review and meta-analysis. Neurology, online ahead of print (PMID: 37550071)

255. Maynard, G., Kannan, R., Liu, J., Wang, W., Lam, T. T., Wang, X., Adamson, C., Hackett, C., Schwab, J. M., Liu, C., Leslie, D. P., Chen, D., Marino, R., Zafonte, R., Flanders, A., Block, G., Smith, E., Strittmatter, S. M. (2023) Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomized clinical trial. Lancet Neurol. 22 (8), 672-684 (PMID: 37479373, PMCID: PMC10410101 (available on 2024-08-01)).

254. Martin-Lopez, E., Vidyadhara, D.J., Liberia, T., Meller, S. J., Harmon, L.E., Hsu, R.M., Han, K., Betül Yücel, B., Chandra, S.S. and Greer, C.A. (2023). Alpha-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson's Disease. J. Neurosci. 43(6): 1051-1071 (Cover article, PMCID: PMC9908323).

253. Malla, A., Yu, H., Farris, D., Kadimi, S., Lam, T.T., Cox, A., Smith, Z., Lesch, B. (2023) DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres. EMBO Reports e56492 online ahead of print (PMID: 37317657, PMCID: PMC10398668 (available on 2024-06-15)).

252. Ketchesin, K.D., Becker-Krail, D.D., Xue, X., Wilson, R.S., Lam, T.T., Williams, K.R., Nairn, A.C., Tseng, G.C., Logan, R.W. (2023) Differential effects of cocaine and morphine on the diurnal regulation of the mouse nucleus accumbens proteome. J. Proteome Res. 22(7): 2377-2390 (PMCID: PMC10392613).

251. Ganesh, S. Lam, T.K., Garcia-Milian, R., D’Souza, D., Nairn, A.C., Elgert, K., Eitan, E., Ranganathan, M. (2023) Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesicles. World J. Biol. Psychiatry 2023 Apr 13;1-11. doi: 10.1080/15622975.2023.2197039. Online ahead of print. (PMID: 36994633).

250. Droit, A., Pelletier, S., Leclerq, M., Roux-Dalvai, F., de Geus, M., Leslie, S., Wang, W., Lam, T., Nairn, A.C., Arnold, S., Carlyle, B., Precioso, F., (2023) Enhancing classification of liquid chromatography mass spectrometry data with Batch Effect Removal Neural Networks (BERNN). Res. Sq. Preprint (PMCID: PMC10350225).

249. de Geus, M. B., Leslie, S. N., Lam, T., Wang, W., Kivisakk, P., Nairn, A. C., Arnold, S. E., Carlyle, B. C. (2023) Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer's Disease in a Large Clinical Sample. Res. Sq. Preprint (PMCID: PMC10350182).

248. Zhang, M., Berk JM, Mehrtash AB, Kanyo J, Hochstrasser M. (2022) A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins. PLoS Biol. 20(6):e3001501 (PMCID: PMC9278747).

247. Yang, M., Horstman, S., Gee, R., Guyer, P., Lam, T.T., Kanyo, J., Perdigoto, A., Speake, C., Greenbaum, C., Callebaut, A., Overbergh, L., Kibbey, R., Herold, K., James, E., Mamula, M.J. (2022) Citrullination of glucokinase is linked to autoimmune diabetes. Nature Commun. 13: 1870 (PMCID: PMC8986778).

246. Yang, M., Connolly, S., Gee, R., Lam,T.T., Kanyo, J., Peng, J., Guyer, P., Syed, F., Tse, H., Clarke, S., Clarke, C., James, E., Speake, C., Evans-Molina, C., Arvan, P., Herold, K., Wen, L., Mamula, M., (2022) Carbonyl posttranslational modification associated with Early-Onset Type 1 Diabetes Autoimmunity. Diabetes 71 (9), 1979-1993 (PMID: 35730902, PMCID: PMC9450849 available on 2023-09-01).

245. Wang, Y., Chen, Y., Garcia-Milian, R., Golla, J., Charkoftaki, G., Lam, T.T., Thompson, D., Vasiliou, V. (2022) Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 368: 110175 (PMCID: PMC9891852).

244. Verreault, M., Segoviano Vilchis, I., Rosenberg, S., Lemaire, N., Schmitt, C., Guehennec, J., Royer-Perron, L., Thomas, J., Lam, T.T., Dingli, F., Loew, D., Ducray, F., Paris, S., Carpentier, C., Marie, Y., Laigle-Donadey, F., Rousseau, A., Pigat, N., Boutillon, F., Bielle, F., Mokhtari, K., Frank, S., de Reyniès, A., Hoang-Xuan, K., Sanson, M., Goffin, V., Idbaih, A. (2022) Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma. Clin. Transl. Med. 12(7) (PMCID: PMC9270581).

243. Shin, N., Marlier, A., Xu, L., Lam, T.T., Cantley, L.G., Guo, J.K. (2022) Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 322(3):F322-F334 (PMCID: PMC8897010).

242. Saland, S., Wilczak, K., Voss, E., Lam, T.T., Kabbaj, M. (2022) Sex-and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine. Scientific Reports 12(1): 1820 (PMCID: PMC8810966).

241. Kandigian, S., Ethier, E., Kitchen, R., Lam, T.T., Arnold, S., Carlyle, B. (2022) Proteomic characterization of post-mortem human brain tissue following ultracentrifugation-based subcellular fractionation Brain Commun. 4(3): fcac103 (PMCID: PMC9123841).

240. Jurkowitz, M., Azad, A., Monsma, P., Keiser, T., Kanyo, J., Lam, T.T., Bell, C., Schlesinger, L. (2022) Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids. J. Biol. Chem. 298(5):101849 (PMCID: PMC9052158).

239. Jarrold, B., Tan, C., Ho, C., Soon, A., Lam, T.T., Yang, X., Nguyen, C., Guo, W., Chew, Y., DeAngelis, Y., Costello, L., De Los Santos Gomez, P., Przyborski, S., Bellanger, S., Dreesen, O., Kimball, A., Oblong, J. (2022) Early onset of senescence and imbalanced epidermal homeostasis across the decades in photoexposed human skin: Fingerprints of inflammaging. Exp. Dermatol. 31(11):1748-1760 (PMID: 36320153).

238. Griffin, K., Walters, B., Li, H., Wang, H., Biancon, G., Tebaldi, T., Kaya, C., Kanyo, J., Lam, T.T., Cox, A., Halene, S., Chung, J., Lesch, B. (2022) Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction. Genome Research 32(9): 1655-1668 (PMCID: PMC9528986).

237. Gorenberg, E., Tieze, S., Yucel, B., Zhao, H., Bishai, J., Chou, V., Wirak, G., Tomita, S., Lam, T.T., Chandra, S.S. (2022) Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PLoS Biol. 20(3): e3001590 (Cover article, PMCID: PMC9004782).

236. Falahati, H., Wu, Y., Feuerer, V., Simon, H., De Camilli P. (2022) Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines. Proc. Natl. Acad. Sci. 119(42): e2203750119 (PMCID: PMC9586327).

235. Brody, A., Nies, S., Guan, F., Smith, L., Mukherjee, B., Salazar, S., Lee, S. Lam, T.T., Strittmatter, S. (2022). Alzheimer risk gene product Pyk2 suppresses Tau phosphorylation and phenotypic effects of tauopathy. Mol. Neurodegeneration 17(1): 32 (PMCID: PMC9063299).

234. Blackburn, J., Jamwal, S., Wang, W., Elsworth, J. (2022) Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochem. Int.152:105222 (PMCID: PMC8712400).

233. Bircher, J., Corcoran, E., Lam, T.T., Trnka, M., Koleske, A.J. (2022) Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants. J. Biol. Chem. 298(9): 102361 (PMCID: PMC9467883).

232. Sitapara, R., Lam, T.T., Gandjeva, A., Tuder, R., Zisman, L. (2021) Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension. Pulmonary Circulation. 11(3) 20458940211031109 (PMCID: PMC8711668).

231. Leslie, S., Kanyo, J. Datta, D., Wilson, R., Zeiss, C., Duque, A., Lam, T.T., Arnsten, A., Nairn, A.C. (2021) Simple, single-shot phosphoproteomic analysis of heat-stable Tau identifies age-related changes in pS235-and pS396-Tau levels in non-human primates. Frontiers in Aging Neuroscience 13: 767322 (PMCID: PMC8637411).

230. Ahsan, N., Rao, R., Wilson, R., Punyamurtula, U., Salvato, F., Petersen, M., Ahmed, M., Abid, M., Verburgt, J., Kihara, D., Yang, Z., Fornelli, L., Foster, S., Ramratnam, B. (2021) Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches. Proteomics 21(10): e2000279 (PMCID: PMC8250252).

229. Zhang, L., Lin, T. V., Yuan, Q., Sadoul, R., Lam, T. T.,Bordey, A. (2021) Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 signaling. J. Neurosci. 41 (17): 3799-3807(PMCID: PMC8084316).

228. Odom, C. V., Kim, Y., Burgess, C. L., Baird, L. A., Korkmaz, F. T., Na, E., Shenoy, A. T., Arafa, E. I., Lam, T. T., Jones, M. R., Mizgerd, J. P., Traber, K. E.,Quinton, L. J. (2021) Liver-Dependent lung remodeling during systemic inflammation shapes responses to secondary infection. J. Immunol. 207(7): 1891-1902 (PMCID: PMC8631467).

227. López, A. J., Johnson, A. R., Euston, T. J., Wilson, R., Nolan, S. O., Brady, L. J., Thibeault, K. C., Kelly, S. J., Kondev, V., Melugin, P., Kutlu, M. G., Chuang, E., Lam, T. T., Kiraly, D. D., Calipari, E. S. (2021)Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Commun. Biol. 4(1): 883 (PMCID: PMC8285523).

226. Lee, A. M., Mansuri, M. S., Wilson, R. S., Lam, T. T., Nairn, A. C., Picciotto, M. R. (2021) Sex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure. Front. Mol. Neurosci. 14: 657064 (PMCID: PMC8317211).

225. Hofford, R. S., Euston, T. J., Wilson, R. S., Meckel, K. R., Peck, E. G., Godino, A., Landry, J. A., Calipari, E. S., Lam, T. T.,Kiraly, D. D. (2021) Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex. J. Neurosci. 41(7): 1553-1565 (PMCID: PMC7896012).

224. Ahsan, N., Wilson, R., Rao, R., Salvato, F., Sabila, M., Ullah, H, Miernyk, J. (2020) Mass Spectrometry-Based identification of Phospho-Tyr in plant proteomics. J. Proteome Res.19(2):561-571 (PMID: 31967836).

223. Taguchi, Y.V., Gorenberg, E.L., Nagy, M., Thrasher, D., Fenton, W.A., Volpicelli-Daley, L., Horwich, A.L., Chandra, S.S., (2020) Hsp110 mitigates a-synuclein pathology in vivo. Proc. Natl. Acad. Sci. U.S.A. 116(48): 24310-24316 (PMCID: PMC6883785).

222. Ryu, C., Walia, A., Ortiz, V., Perry, C., Woo,S., Reeves, B.C. Sun, H., Winkler, J., Kanyo, J.E., Wang, W., Vukmirovic, M., Ristic, N., Stratton, E.A., Meena, S.R., Minasyan, M., Kurbanov, D., Liu, X., Lam, T.T., Farina, G., Gomez, J.l., Gulati, M., Herzog, E.L. (2020) Bioactive plasma mitochondrial DNA is associated with disease progression in scleroderma associated interstitial lung disease. Arthritis & Rheumatology 72(11): 1905-1915 (PMCID: PMC8081728).

221. Piersigilli, F., Syed, M., Lam, T. T., Dotta, A., Massoud, M., Vernocchi, P., Quagliariello, A., Putignani, L., Auriti, C., Salvatori, G., Bagolan, P., Bhandari, V. (2020) An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling. J. Perinatol. 40 (6), 952-961, (PMID: 32080334).

220. Nakamura, Y., Morrow, D.H., Nathanson, A.J., Henley, J.M., Wilkinson, K.A., Moss, S.J. (2020) Phosphorylation on Ser-359 of the a2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses. J. Biol. Chem. 295(35), 12330-12342, (JBC Editor’s Pick Publication, PMCID: PMC7458806).

219. Mansuri, M., Peng, G.,.Wilson, R., Lam, T., Zhao, H., Williams, K., Nairn, A. (2020) Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-expressing Medium Spiny Neurons. Proteomes 8(4) 27, (PMCID: PMC7709116).

218. Li, X., Terunuma, M., Deeb, T.G., Wiseman, S., Pangalos, M.N., Nairn, A.C., Moss, S.J., Slesinger, P.A. (2020) Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling. J. Neurosci. 40(14), 2808-2816, (PMCID: PMC7117905).

217. Kandyliari, A.,Mallouchos, A., Papandroulakis, N., Golla, J.P., Lam, T.T., Sakellari, A., Karavoltsos, S., Vasiliou, V., Kapsokefalou, M. (2020) Nutrient composition and fatty acid and protein profiles of selected fish by-products Foods 9(2), 190, (PMCID: PMC7074476).

216. Franzen, A.,Lam, T.,Williams, K., Nairn, A., Duman, R.,Sathyanesan, M.,Kumar, V., Carpenter, L.,Sathyanesan, S. (2020) Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry. BMC Psychiatry 20(1), 481, (PMCID: PMC7528485).

215. Chen, M., Sun, H., Boot, M., Shao, L., Chang, S.J., Wang, W., Lam, T.T., Lara-Tejero, M., Rego, E.H., Galán, J.E. (2020) Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science 369(6502), 450-455, (PMCID: PMC8020367).

214. Ahsan, M.K., Figueroa-Hall, L., Baratta, V., Garcia-Milian, R., Lam, T.T., Hoque, K., Salas, P.J., Ameen, N.A. (2020) Glucocorticoids and serum-and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. American Journal of Physiology-Gastrointestinal and Liver Physiology 319(2), G121-G132, (PMCID: PMC7500270).