Prashanth Vallabhajosyula, MD, MS
Cards
About
Research
Publications
2024
The role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies
Ahmed A, Hameed I, Vallabhajosyula P. The role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies. Journal Of Clinical Anesthesia And Intensive Care 2024, 4: 6-7. DOI: 10.46439/anesthesia.4.019.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm
Kostiuk V, Vallabhajosyula P, Nassiri N, Tonnessen B. Thoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm. Annals Of Vascular Surgery - Brief Reports And Innovations 2024, 4: 100302. DOI: 10.1016/j.avsurg.2024.100302.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repairEndovascular aneurysm repairAneurysm repairAcute type B aortic dissectionAcute onset chest painWeeks of antibiotic treatmentType B aortic dissectionAnti-impulse therapyExclusion of hemorrhageOnset chest painAortic arch debranchingPost-operative courseB aortic dissectionComputed tomography angiogramThoracic aortic aneurysmZone 0 TEVARArch debranchingMediastinal infectionChest painContrast extravasationBack painAntibiotic treatmentAortic aneurysmPost-operativelyFollow-upPeripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies
Hu R, Korutla L, Vallabhajosyula P. Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies. Annals Of Surgical Oncology 2024, 31: 4179-4181. PMID: 38755337, DOI: 10.1245/s10434-024-15400-y.Peer-Reviewed Original ResearchEfficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation
Piccini J, Ahlsson A, Dorian P, Gillinov A, Kowey P, Mack M, Milano C, Noiseux N, Perrault L, Ryan W, Steinberg J, Voisine P, Waldron N, Gleason K, Titanji W, Leaback R, O’Sullivan A, Ferguson W, Benussi S, Investigators N, Akhter S, Andreas M, Benussi S, Castella M, Dalrymple-Hay M, El-Eshmawi A, Groh M, Hanke T, Jeanmart H, Katz M, McCullough J, Melby S, Miller J, Noiseux N, Romano M, Perrault L, Piccini J, Podgoreanu M, Ryan W, Sharma V, Shults C, Teman N, Voisine P, Whitson B, Wickbom A, Vallabhajosyula P, Yau T. Efficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation. JACC Clinical Electrophysiology 2024, 10: 930-940. PMID: 38661602, DOI: 10.1016/j.jacep.2024.01.020.Peer-Reviewed Original ResearchPrevention of postoperative atrial fibrillationPostoperative atrial fibrillationCoronary artery bypass graftingRate of postoperative atrial fibrillationSafety of botulinum toxin type ACardiac surgeryPrimary endpointBotulinum toxin type AToxin type AAtrial fibrillationAssociated with increased morbidityRate of adverse eventsDose-ranging studyPlacebo-controlled trialOpen-chest cardiac surgeryType of surgeryEpicardial fat padsInjection of botulinum toxinArtery bypass graftingRandomized clinical trialsPlacebo-ControlledValve surgeryDouble-blindPlacebo groupContinuous AFIntimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findingsLiving in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceBicuspid Aortic Valve: Current Therapeutic Strategies
Usman Bin Mahmood S, Vallabhajosyula P, Milewski R. Bicuspid Aortic Valve: Current Therapeutic Strategies. 2024, 1 DOI: 10.5772/intechopen.113315.Peer-Reviewed Original ResearchBicuspid aortic valveAortic valveTherapeutic strategiesValve-sparing root reimplantationBicuspid aortic valve patientsBAV syndromeSurgical therapeutic strategiesAortic valve replacementAortic valve patientsAortic valve stenosisAortic valve repairLong-term outcomesCurrent therapeutic strategiesBAV populationAorta replacementBentall procedureValve patientsValve replacementValve stenosisRoot reimplantationValve repairValvular pathologySurgical proceduresGeneral populationIndividualized approachContributors to Volume 2
Abouljoud M, Abu-Gazala S, Akbulut S, Al Harakeh H, Aleassa E, Alqahtani S, Ascher N, Asolati M, Aucejo F, Bababekov Y, Baker T, Barth R, Bayer J, Benedetti E, Benedetti C, Bhati C, Bizzaro D, Bond G, Braun H, Broelsch C, Broering D, Bromberg J, Brown R, Brucker S, Bui J, Burra P, Cagliani J, Carr-Boyd P, Cascalho M, Cattral M, Chan S, Chen C, Cherqui D, Ciria R, Crane A, Cravedi P, Kwon C, de Magnee C, Delmonico F, De Prisco G, Di Bella C, Di Cocco P, di Sabato D, Diaz G, Dudkowski M, Eagle E, Eisenson D, Emond J, Emre S, Ericzon B, Florman S, Freise C, Fronek J, Fung J, Furian L, Ganoza A, Genedy L, Giacomo G, Giglio M, Gorrell D, Gruessner R, Gruessner A, Hashimoto K, Heffron N, Heffron T, Heimbach J, Hester J, Hibi T, Hirao H, Humar A, Hwang S, Iesari S, Ince V, Isik B, Issa F, Jacobs C, Järvholm S, Jeon H, Johannesson L, Kalis A, Kaplan A, Khan K, Khanna A, Kim K, Kim W, Kittle H, Knechtle S, Koppe S, Kord A, Kristek J, Kumar S, Kupiec-Weglinski J, Lake J, LaMattina J, Lee S, Lerut J, Lin T, Bianco E, Lo C, Malago M, Malik S, Maluf D, Marique L, Martin D, Mazariegos G, Mazariegos G, McCallion O, McGraw L, Meier R, Merola J, Miller C, Moon D, Moore H, Muller Y, Nadalin S, Nada A, Nakamura K, Ogle B, Ogura Y, Olausson M, Olthoff K, Ong A, Paci P, Piedrahita J, Pinna A, Pirotte T, Pita A, Platt J, Pomfret E, Pomposelli J, Quintini C, Reding R, Renz J, Rizzari M, Roberts J, Roggen F, Roll G, Sachs D, Salerno D, Samstein B, Schmitz R, Selzner N, Senzolo M, Sonmez T, Stock P, Tabrizian P, Tambucci R, Tanaka K, Testa G, Thaker S, Thomson M, Tranäng M, Troisi R, Tulla K, Tully M, Tumeh J, Tzvetanov I, Umman V, Unver U, Vallabhajosyula P, Wahid N, Wilczek H, Williams N, Xie J, Yamada K, Yilmaz S, Zanetto A, Zaza G, Zeytunlu M. Contributors to Volume 2. 2024, xiii-xviii. DOI: 10.1016/b978-0-443-23571-9.01004-5.Peer-Reviewed Original Research
2023
Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies
Hameed I, Ahmed A, Pupovac S, Nassiri N, Assi R, Vallabhajosyula P. Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies. JTCVS Open 2023, 17: 23-36. PMID: 38420535, PMCID: PMC10897673, DOI: 10.1016/j.xjon.2023.12.004.Peer-Reviewed Original ResearchHybrid aortic arch repairThoracic endovascular repairAortic arch repairAortic remodelingArch repairLuminal diameterZone 0Complete false lumen thrombosisLeft inferior pulmonary veinThoracic endovascular aortic repairComputed tomography angiography scansFalse lumen obliterationInferior left atriumFalse lumen thrombosisHigh-risk patientsHybrid arch repairAortic arch pathologiesCommon iliac arteryEndovascular aortic repairAdjunctive treatment strategyInferior pulmonary veinShort-term outcomesThoracic aortic pathologyTomography angiography scansAorta remodelingCirculating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantation
Clinical Trials
Current Trials
Safe and Timely Antithrombotic Removal - Direct Oral Anticoagulants Apixaban & Rivaroxaban (STAR-D)
HIC ID2000031974RoleSub InvestigatorPrimary Completion Date03/31/2023Recruiting ParticipantsGenderBothAge18+ yearsAnticoagulation for New-Onset Post-Operative Atrial Fibrillation after Coronary Artery Bypass Surgery
HIC ID2000027269RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18+ yearsCorMatrix Cor TRICUSPID ECM Valve Replacement Study
HIC ID2000028726RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge1 year - 70 years
Clinical Care
Overview
Prashanth Vallabhajosyula, MD, MS, is surgical director of the Aortic Institute, which is part of the Yale New Haven Health Heart & Vascular Center. He is a cardiothoracic surgeon who performs the entire spectrum of heart surgeries, including coronary artery bypass grafting, valve surgery, and heart transplantation. His primary focus is endovascular and open surgeries of the aorta, and hybrid surgeries that combine the two.
Dr. Vallabhajosyula is skilled in complex procedures, such as thoracic endovascular aortic repair (TEVAR), a minimally invasive procedure that uses a stent graft to reinforce an aneurysm and prevent it from bursting. He also introduced pulmonary thromboendarterectomy to Yale. The latter is a highly specialized surgical procedure that removes chronic blood clots from the arteries in the lung.
As director of the Aortic Institute, Dr. Vallabhajosyula says a large part of his work is coordinating and integrating a variety of services. “A multidisciplinary approach is important, because what we can offer patients for a particular aortic disease is rapidly evolving,” Dr. Vallabhajosyula says, explaining this that can change how different specialists can contribute to a case. “People draw arbitrary lines around what vascular surgery will do, what cardiology will do, and what a heart surgeon will do, but patients don't always understand that or come in that way. Our goal is to integrate all the services and provide a single place for patients to come if they have an aortic problem.”
Dr. Vallabhajosyula says one thing that led him to medicine was a lifelong love of science. “When I was in sixth grade, growing up in India, my mother took me to a medical university for a show they had where kids from elementary school could see human bones,” he says. “There was an anatomy lab going on, and I snuck into it and saw some cadavers. I wasn’t scared at all. I was fascinated by the human body and with seeing all these parts, and truly understanding that there is such an organic basis to everything that we do. I was hooked from the very beginning.”
He also enjoyed any experience that involved helping people, which led to his decision to be a surgeon. “Patient care is a phenomenal thing,” he says. While patients and their families are grateful for what he can do for them, he also gets a lot back, he adds. “I really try to understand patients for who they are and where they are coming from. If you approach patient care that way, you come to realize that we're all pretty similar. I think that’s made me a better person,” he says.
Clinical Specialties
Fact Sheets
Endovascular Debranching Aortic Repair for Thoracoabdominal Aortic Aneurysms
Learn More on Yale MedicineAortic Aneurysm
Learn More on Yale MedicinePulmonary Thromboendarterectomy
Learn More on Yale MedicineCoronary Artery Bypass Grafting (CABG)
Learn More on Yale Medicine
Yale Medicine News
Links & Media
News
- June 04, 2024
Surgery Research Presented at Blavatnik Fund for Innovation at Yale
- May 02, 2024
Yale Surgeons Recognized by Connecticut Magazine's 2024 “Top Doctors” List
- April 16, 2024
Exosomes: A Promising Biomarker for Cellular Rejection After Organ Transplant
- February 05, 2024Source: Yale Medicine
How a Pulmonary Thromboendarterectomy Can Fix a Type of Pulmonary Hypertension
Get In Touch
Contacts
Cardiac Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.