2020
The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms
Cui J, Qu Z, Harata-Lee Y, Shen H, Aung TN, Wang W, Kortschak RD, Adelson DL. The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms. PLOS ONE 2020, 15: e0236395. PMID: 32730293, PMCID: PMC7392229, DOI: 10.1371/journal.pone.0236395.Peer-Reviewed Original ResearchConceptsCore candidate genesCandidate pathwaysCandidate genesDifferential gene expression resultsGene expressionDNA replication/repairCompound Kushen InjectionTranscriptome-based analysisReplication/repairCancer cell linesEffect of CKITranscriptome data analysisCandidate molecular mechanismsCell cycle regulatorsMolecular changesCell linesGene expression resultsCell cycle phasesCell cycle arrestDE genesRegulatory relationshipsCycle regulatorsCell cycleMolecular mechanismsExpression resultsDependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform
Sung Y, Tetrault M, Takahashi K, Ouyang J, Pratx G, Fakhri G, Normandin M. Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform. Scientific Reports 2020, 10: 4280. PMID: 32152343, PMCID: PMC7062696, DOI: 10.1038/s41598-020-59515-0.Peer-Reviewed Original ResearchConceptsCell divisionHeLa cellsDry massM phaseCell dry massCancer compared to normal tissuesCell cycle phasesHouse-keeping proteinsSingle-cell studiesSingle-cell levelIncreased dry massProliferation indexCell cycleG1 phaseProportion of cellsHigher glucose uptakeFluorodeoxyglucose uptakeGlucose uptakeHeLaUptake rate
2019
Cell cycle dynamics in the reprogramming of cellular identity
Hu X, Eastman AE, Guo S. Cell cycle dynamics in the reprogramming of cellular identity. FEBS Letters 2019, 593: 2840-2852. PMID: 31562821, DOI: 10.1002/1873-3468.13625.Peer-Reviewed Original ResearchConceptsCell fate reprogrammingCell cycle dynamicsCellular identityDaughter cellsGenome replicationCell cycleSpecific cell cycle phasesCell fate regulationCell cycle controlRapid cell cyclesCell cycle phasesCycle dynamicsFate regulationEpigenomic changesCycle controlFate controlReprogrammingCell typesBiochemical processesReplicationComplex mechanismsCycle phaseGenomeCellsProminent example
2018
Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
Lin ZP, Zhu YL, Ratner ES. Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers. Frontiers In Oncology 2018, 8: 303. PMID: 30135856, PMCID: PMC6092490, DOI: 10.3389/fonc.2018.00303.Peer-Reviewed Original ResearchCDK activityCell cycleDefective cell cycle regulationCyclin-dependent kinase activityCell cycle phase transitionCell cycle regulationCyclin-dependent kinasesNormal cell cycleHomologous recombination repairHallmarks of cancerTargeting Cyclin-Dependent KinasesSynthetic lethal approachCell cycle phasesSmall molecule inhibitorsGynecologic cancerCheckpoint activationPARP inhibitorsCycle regulationHR repairKinase activityRecombination repairDNA damaging modalitiesProtein targetsCDKMajor gynecologic malignancies
2016
Radiosensitization effect of Huaier on breast cancer cells
DING X, YANG Q, KONG X, HAFFTY BG, GAO S, MORAN MS. Radiosensitization effect of Huaier on breast cancer cells. Oncology Reports 2016, 35: 2843-2850. PMID: 26935024, DOI: 10.3892/or.2016.4630.Peer-Reviewed Original ResearchConceptsBreast cancer cellsDNA repairTraditional Chinese medicineCell cycleBreast cancerCancer cellsDNA repair pathwaysCell cycle-regulating proteinsHomologous recombination pathwayRadiosensitization effectMulti-biological functionsCell cycle phasesColony formation assaysMDA-MB-468 cellsΓ-H2AX fociCell divisionRepair pathwaysG0/G1Treatment strategiesMicroarray assayRecombination pathwayFormation assaysHuaierCancer treatmentWestern blotting
1978
Characteristics of the Fc Receptor Induced by Herpes Simplex Virus
Costa J, Yee C, Nakamura Y, Rabson A. Characteristics of the Fc Receptor Induced by Herpes Simplex Virus. Intervirology 1978, 10: 32-39. PMID: 75867, DOI: 10.1159/000148965.Peer-Reviewed Original Research
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