2025
A Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab
Kallenberger E, Kaur S, Everist B, Ator G, Gierer S, D’Mello A. A Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab. Otology & Neurotology 2025, 46: e210-e214. PMID: 40360240, DOI: 10.1097/mao.0000000000004501.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, Monoclonal, HumanizedChronic DiseaseHearing LossHumansOtitis Media with EffusionRetrospective StudiesTreatment OutcomeConceptsChronic otitis mediaGlue earOtitis mediaTreatment of glue earPatient-reported incidencePatient-reported symptomsPresence of eosinophilic inflammationTreating chronic otitis mediaAudiometric dataInjection of dupilumabCase 2Efficacy of dupilumabHearing lossInterruption of treatmentNonsurgical treatment optionsEar painDupilumab therapyEar drainageEar infectionsSurgical treatmentEosinophilic inflammationCase seriesDupilumabAtopic conditionsTreatment options
2023
Outcomes and Management of Infants Who Refer Newborn Hearing Screening
Schild S, Mendelsohn M, Plum A, Goldstein N. Outcomes and Management of Infants Who Refer Newborn Hearing Screening. Annals Of Otology Rhinology & Laryngology 2023, 132: 1662-1668. PMID: 37322843, DOI: 10.1177/00034894231180949.Peer-Reviewed Original ResearchMeSH KeywordsChildHearing LossHearing Loss, SensorineuralHearing TestsHumansInfantInfant, NewbornNeonatal ScreeningOtitis Media with EffusionOtoacoustic Emissions, SpontaneousConceptsSensorineural hearing lossAuditory brainstem responseHearing lossTube placementTertiary care pediatric otolaryngology practiceOtoacoustic emissionsNormal hearingBone-anchored hearing aidUniversal newborn hearing screeningManagement of infantsNewborn hearing screeningPediatric otolaryngology practiceHearing aidsCongenital cytomegalovirusChart reviewMost patientsUtero infectionNewborn hearingOtitis mediaTube insertionHearing screeningBrainstem responseCommon pathologyOtolaryngology practiceEarly diagnosisTwo‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System
Waldman E, Ingram A, Vidrine D, Gould A, Zeiders J, Ow R, Thompson C, Moss J, Mehta R, McClay J, Brenski A, Gavin J, Ansley J, Yen D, Chadha N, Murray M, Kozak F, York C, Brown D, Grunstein E, Sprecher R, Sherman D, Schoem S, Puchalski R, Hills S, Harfe D, England L, Syms C, Lustig L. Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System. Otolaryngology 2023, 169: 692-700. PMID: 37003297, DOI: 10.1002/ohn.336.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolHumansIontophoresisLidocaineMiddle Ear VentilationOtitis Media with EffusionProspective StudiesTympanic MembraneConceptsEpinephrine iontophoresisTube placementTube retentionOperating roomChildren ages 6 monthsCohort of patientsTwo-Year OutcomesAge 6 monthsDelivery systemComplication rateGeneral anesthesiaLocal anesthesiaOtolaryngology practiceTympanostomyPatientsMonthsIontophoresisTympanic membraneAnesthesiaTube displacementAdditional leadsCohortDelivery resultsOutcomesEar
2020
Considerations in Management of Acute Otitis Media in the COVID-19 Era
Mohan S, Workman A, Barshak M, Welling D, Abdul-Aziz D. Considerations in Management of Acute Otitis Media in the COVID-19 Era. Annals Of Otology Rhinology & Laryngology 2020, 130: 520-527. PMID: 32911957, DOI: 10.1177/0003489420958443.Peer-Reviewed Original ResearchConceptsMiddle ear fluidAcute otitis mediaComplicated acute otitis mediaEar fluidOtitis mediaSARS-CoV-2 infectionSARS-CoV-2Management of Acute Otitis MediaFacial paralysisPCR of nasopharyngeal swabClinical management of patientsPositive viral PCRTreated with myringotomyManagement of patientsBlue light filterCadaveric temporal bonesOtologic findingsSystemic antibioticsEar diseaseNegative PCRAcute infectionClinical managementOtologic proceduresProlonged close contactNasopharyngeal swabs
2005
Estimation of the intervention effect in a non‐randomized study with pre‐ and post‐mismeasured binary responses
Lin H, Lyles R, Williamson J, Kunselman A. Estimation of the intervention effect in a non‐randomized study with pre‐ and post‐mismeasured binary responses. Statistics In Medicine 2005, 24: 419-435. PMID: 15543548, DOI: 10.1002/sim.1957.Peer-Reviewed Original ResearchConceptsIntervention effectsBinary disease outcomeNon-randomized studiesBinary outcomesInterventionSubject participationFollow-upDisease statusPositive diagnostic testDisease outcomeRegressionRegression effectsNon-randomized clinical studyOutcomesDiagnostic testsMisclassificationPlacebo-controlled studySubjectsSelection criteriaParticipantsEvent probabilitiesStudy
2002
Bias in a placebo-controlled study due to mismeasurement of disease status and the regression effect
Lin H, Lyles R, Williamson J. Bias in a placebo-controlled study due to mismeasurement of disease status and the regression effect. Contemporary Clinical Trials 2002, 23: 497-501. PMID: 12392863, DOI: 10.1016/s0197-2456(02)00229-5.Peer-Reviewed Original ResearchConceptsProportion of diseased individualsFollow-upIntervention effectsDichotomous diseaseDisease statusPlacebo groupFollow-up conditionsRandomized clinical trialsDiagnostic testsPlacebo-controlled studyPositive predictive valueInterventionFalse-positive valuesRegression effectsClinical trialsPredictive valueScreeningStatusRegressionTrialsDiseased individualsStatistical analysis
1998
The Effect of Masker Interaural Time Delay on the Masking Level Difference in Children with History of Normal Hearing or History of Otitis Media with Effusion
Hall J, Grose J, Dev M, Ghiassi S. The Effect of Masker Interaural Time Delay on the Masking Level Difference in Children with History of Normal Hearing or History of Otitis Media with Effusion. Ear & Hearing 1998, 19: 429-433. PMID: 9867291, DOI: 10.1097/00003446-199812000-00004.Peer-Reviewed Original Research
1992
Mechanisms of Retraction Pocket Formation in the Pediatric Tympanic Membrane
Ruah C, Schachern P, Paparella M, Zelterman D. Mechanisms of Retraction Pocket Formation in the Pediatric Tympanic Membrane. JAMA Otolaryngology - Head & Neck Surgery 1992, 118: 1298-1305. PMID: 1449688, DOI: 10.1001/archotol.1992.01880120024005.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsChild, PreschoolHumansInfantInfant, NewbornOtitis Media with EffusionOtitis Media, SuppurativeTympanic MembraneConceptsSerous otitis mediaOtitis mediaPurulent otitis mediaTemporal bonePosterosuperior quadrantTympanic membraneType of cholesteatomaImportant risk factorPars tensaEpidemiological natureRetraction pocket formationPars flaccidaYears 6 monthsGreater inflammatory reactionClinical findingsRisk factorsInflammatory reactionCholesteatomaPocket formationAgeBoneChildrenTensaQuadrantDisease
1991
Middle Ear Fluid Lysozyme Source in Experimental Pneumococcal Otitis Media
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Middle Ear Fluid Lysozyme Source in Experimental Pneumococcal Otitis Media. Annals Of Otology Rhinology & Laryngology 1991, 100: 593-596. PMID: 2064274, DOI: 10.1177/000348949110000715.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsChinchillaLeukocyte CountMuramidaseOtitis Media with EffusionPneumococcal InfectionsConceptsMiddle ear fluidPneumococcal otitis mediaInflammatory cellsOtitis mediaInflammatory mediatorsAcute pneumococcal otitis mediaExperimental pneumococcal otitis mediaAcute otitis mediaChronic otitis mediaImportant inflammatory mediatorsMiddle ear inflammationMiddle ear infectionMiddle ear environmentFuture therapeutic interventionsMucosal epithelial cellsMiddle ear epitheliumSource of lysozymeEar inflammationEar infectionsInflammatory responseEar fluidDirect stimulationTherapeutic interventionsStreptococcus pneumoniaeMiddle earEarly Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid. Annals Of Otology Rhinology & Laryngology 1991, 100: 385-388. PMID: 1850967, DOI: 10.1177/000348949110000507.Peer-Reviewed Original ResearchMeSH Keywords6-Ketoprostaglandin F1 alphaAnimalsArachidonic AcidArachidonic AcidsChinchillaDinoprostoneLeukotriene B4Otitis Media with EffusionPneumococcal InfectionsSRS-ATime FactorsConceptsMiddle ear fluidArachidonic acid metabolitesEar fluidLeukotriene B4Acid metabolitesPneumococcal otitis mediaSubsequent inflammatory responseInflammatory cell chemotaxisStreptococcus pneumoniae organismsMiddle ear inoculationInflammatory cellsOtitis mediaF1 alphaInflammatory responseProstaglandin E2Pneumoniae organismsArachidonate metabolitesArachidonic acidCell chemotaxisEar inoculationEarly biochemical eventsSignificant increaseInitial stimulusHoursMetabolites
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply