2020
Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial
Shaikh N, Shope T, Hoberman A, Muniz G, Bhatnagar S, Nowalk A, Hickey R, Michaels M, Kearney D, Rockette H, Charron M, Lim R, Majd M, Shalaby-Rana E, Kurs-Lasky M, Cohen D, Wald E, Lockhart G, Pohl H, Martin J. Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Pediatric Nephrology 2020, 35: 2113-2120. PMID: 32556960, PMCID: PMC7529851, DOI: 10.1007/s00467-020-04622-3.Peer-Reviewed Original ResearchConceptsFebrile urinary tract infectionUrinary tract infectionAdjuvant systemic corticosteroidsKidney scarringSystemic corticosteroidsTract infectionsInitiate urinary tract infectionReducing kidney scarringEfficacy of corticosteroidsMethodsChildren aged 2Absolute risk reductionRandomized to corticosteroidsMonths to 6Statistically significant differencePlacebo groupAdjuvant corticosteroidsCorticosteroidsKidney scansPlaceboSignificant differenceAged 2ScarsKidneyInfectionMonths
2018
Effects of processing adjuvants on traditional Chinese herbs
Chen LL, Verpoorte R, Yen H, Peng W, Cheng Y, Chao J, Pao L. Effects of processing adjuvants on traditional Chinese herbs. Journal Of Food And Drug Analysis 2018, 26: s96-s114. PMID: 29703391, PMCID: PMC9326876, DOI: 10.1016/j.jfda.2018.02.004.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, PharmaceuticAnimalsDrug CompoundingDrugs, Chinese HerbalHumansMedicine, Chinese TraditionalConceptsDrug dissolutionDecoction piecesPharmaceutical techniquesOwn pharmacological effectsSynergistic effectMedicinal raw materialsRaw materialsPhysical transformationsCrude drugsToxic componentsActive ingredientsTraditional Chinese medicineChemistryDissolutionChemicalsDrug pharmacokineticsChinese medicinePharmacological effects
2014
Self-efficacy for coping with symptoms moderates the relationship between physical symptoms and well-being in breast cancer survivors taking adjuvant endocrine therapy
Shelby R, Edmond S, Wren A, Keefe F, Peppercorn J, Marcom P, Blackwell K, Kimmick G. Self-efficacy for coping with symptoms moderates the relationship between physical symptoms and well-being in breast cancer survivors taking adjuvant endocrine therapy. Supportive Care In Cancer 2014, 22: 2851-2859. PMID: 24821365, DOI: 10.1007/s00520-014-2269-1.Peer-Reviewed Original ResearchConceptsAdjuvant endocrine therapyBreast cancer survivorsEndocrine therapyPhysical symptomsCancer survivorsBreast cancerTreatment side effectsQuality of lifeResultsMultiple linear regression analysisMethodsOne hundredGreater physical symptomsSide effectsPsychosocial interventionsLinear regression analysisSymptomsPurposeThis studyTherapyWomenRegression analysisCancerSurvivorsFuture studiesHigh levels
2012
Hypersensitivity Reactions to Vaccine Constituents
Leventhal JS, Berger EM, Brauer JA, Cohen DE. Hypersensitivity Reactions to Vaccine Constituents. Dermatitis 2012, 23: 102-109. PMID: 22653170, DOI: 10.1097/der.0b013e31825228cf.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsCutaneous delayed-type hypersensitivityDelayed-type hypersensitivity reactionDelayed-type hypersensitivityChoice of vaccineElicit adverse reactionsComponents of vaccinesClinical manifestationsVaccine safetyAdverse reactionsVaccine constituentsCommon vaccinesDrug AdministrationSusceptible individualsVaccineHypersensitivityPatientsAdjuvantPhysiciansAdministrationThimerosal
2008
Integrin Agonists as Adjuvants in Chemotherapy for Melanoma
Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D. Integrin Agonists as Adjuvants in Chemotherapy for Melanoma. Clinical Cancer Research 2008, 14: 6193-6197. PMID: 18829498, DOI: 10.1158/1078-0432.ccr-08-1285.Peer-Reviewed Original ResearchConceptsMelanoma linesExtracellular matrixMetastatic melanomaM21 tumorsTherapeutic responseImmunodeficient miceTumor volumeChemotherapyClonal growth assaysTherapy resistanceTumor growthHuman melanomaChemotherapeutic efficacyMelanomaTumor cellsDrug 1Survival assaysM21 cellsM21 melanomaSmall nestsIntegrin agonistsIntegrin-dependent adhesionTumorsMiceSnake venom
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