2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
2012
Hypersensitivity Reactions to Vaccine Constituents
Leventhal JS, Berger EM, Brauer JA, Cohen DE. Hypersensitivity Reactions to Vaccine Constituents. Dermatitis 2012, 23: 102-109. PMID: 22653170, DOI: 10.1097/der.0b013e31825228cf.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsCutaneous delayed-type hypersensitivityDelayed-type hypersensitivity reactionDelayed-type hypersensitivityChoice of vaccineElicit adverse reactionsComponents of vaccinesClinical manifestationsVaccine safetyAdverse reactionsVaccine constituentsCommon vaccinesDrug AdministrationSusceptible individualsVaccineHypersensitivityPatientsAdjuvantPhysiciansAdministrationThimerosal
2007
Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial
Santin AD, Bellone S, Palmieri M, Zanolini A, Ravaggi A, Siegel ER, Roman JJ, Pecorelli S, Cannon MJ. Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial. Journal Of Virology 2007, 82: 1968-1979. PMID: 18057249, PMCID: PMC2258728, DOI: 10.1128/jvi.02343-07.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, ViralAntibody FormationCancer VaccinesCarcinomaCD4-Positive T-LymphocytesDendritic CellsDNA-Binding ProteinsEnzyme-Linked Immunosorbent AssayFemaleHemocyaninsHumansImmunity, CellularNeoplasm StagingOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus VaccinesRecombinant ProteinsUterine Cervical NeoplasmsVaccinationConceptsCervical cancer patientsIIA cervical cancer patientsDendritic cell vaccinationHuman papillomavirus type 16Cancer patientsDC vaccinationStage IBPapillomavirus type 16Cell vaccinationE7 antigenType 16Delayed-type hypersensitivity reactionEnzyme-linked immunosorbent spotHPV E7 antigenLimited tumor burdenT-cell countsEvidence of diseaseIIA cervical cancerT cell responsesKeyhole limpet hemocyaninEnzyme-linked immunosorbentHPV16/18 E7Vaccine doseAutologous DCsDTH response
2005
Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis
Girardi M, Duncan KO, Tigelaar RE, Imaeda S, Watsky KL, McNiff JM. Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis. American Journal Of Dermatopathology 2005, 27: 343-346. PMID: 16121058, DOI: 10.1097/01.dad.0000160982.75176.6c.Peer-Reviewed Original ResearchConceptsAcute generalized exanthematous pustulosisPatch test resultsPositive patch test resultsGeneralized exanthematous pustulosisLymphocyte proliferative responsesProliferative responseExanthematous pustulosisPeripheral T-cell proliferative responsesT cell-mediated immune responsesDrug-specific T cellsVitro lymphocyte proliferative responseCalcium channel blocker diltiazemCell-mediated immune responsesDelayed-type hypersensitivity reactionT cell proliferative responsesAdverse cutaneous reactionsLymphocyte proliferation responseChannel blocker diltiazemCell proliferative responsesPatch test sitesNeutrophilic pustulesClinical responsePerivascular lymphocytesCutaneous reactionsHypersensitivity reactions
2001
Latex sensitivity in a macaque (Macaca mulatta).
Macy J, Huether M, Beattie T, Findlay H, Zeiss C. Latex sensitivity in a macaque (Macaca mulatta). Journal Of The American Association For Laboratory Animal Science 2001, 51: 467-72. PMID: 11924808.Peer-Reviewed Original ResearchConceptsDelayed-type hypersensitivity reactionFlares of dermatitisAllergen-specific IgE testingSkin prick testPunch biopsy specimenAdult Macaca mulattaDifferen-tial diagnosisLatex sensitivityCorneal stainingThyroid profilePrick testAtopic dermatitisIgE testingLatex allergyHypersensitivity reactionsBiopsy specimenContact allergensSignificant inflammationEosinophilic dermatitisOriginal biopsyInguinal regionAllergic dermatitisSkin scrapingsVinyl glovesFourteen weeks
1998
Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features
Bernhagen J, Calandra T, Bucala R. Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features. Journal Of Molecular Medicine 1998, 76: 151-161. PMID: 9535548, DOI: 10.1007/s001090050204.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorDelayed-type hypersensitivity reactionNegative septic shockB cell responsesMIF productionSeptic shockImmunosuppressive effectsHypersensitivity reactionsImmune responseImmunological functionsCell responsesHost macrophagesCritical mediatorGlucocorticoidsMediatorsBiological roleResponseCytokine structureCytokinesDiseaseMacrophagesStress response
1997
MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans
Doyle H, Murphy J. MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans. Journal Of Leukocyte Biology 1997, 61: 147-155. PMID: 9021919, DOI: 10.1002/jlb.61.2.147.Peer-Reviewed Original ResearchConceptsMIP-1 alphaMIP-1 alpha levelsDelayed-type hypersensitivity reactionImmunized miceHypersensitivity reactionsC. neoformansCell-mediated immune responsesInflammatory protein-1 alphaCryptococcus neoformansAlpha levelsDTH reaction sitesInflux of neutrophilsNumber of neutrophilsProtein-1 alphaClearance of microorganismsGelatin sponge modelCMI responsesCryptococcal antigenNeutrophil influxNaive miceDTH reactionLeukocyte infiltrationMIP-1αChemotactic cytokinesImmune response
1994
Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia
Bernhagen J, Calandra T, Cerami A, Bucala R. Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia. Trends In Microbiology 1994, 2: 198-201. PMID: 8087451, DOI: 10.1016/0966-842x(94)90111-h.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorDelayed-type hypersensitivity reactionSystemic inflammatory responseIdentification of MIFT-cell productsCentral nervous systemAnterior pituitary glandHypersensitivity reactionsNeuroendocrine mediatorsInflammatory responseNervous systemPituitary glandCell productsEndotoxaemiaMajor protein constituentPituitaryHormoneProtein constituents
1990
Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions.
Girolomoni G, Tigelaar R. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. The Journal Of Immunology 1990, 145: 1105-12. PMID: 2380551, DOI: 10.4049/jimmunol.145.4.1105.Peer-Reviewed Original ResearchConceptsDelayed-type hypersensitivity reactionPrimary sensory neuronsHypersensitivity reactionsSensory neuronsCapsaicin-sensitive primary sensory neuronsBALB/c miceCapsaicin-pretreated miceEffector T cellsContact sensitivity reactionAdoptive transfer experimentsCutaneous inflammatory reactionsTopical capsaicinCapsaicin pretreatmentNeurogenic inflammationC miceNeuropeptide releaseHistologic studyInflammatory reactionT cellsPeptidergic neuronsIrritant reactionsSensitivity reactionsSuch neuronsCapsaicinPotent modulator
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