2022
Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation
Nalawansha DA, Li K, Hines J, Crews CM. Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation. Journal Of The American Chemical Society 2022, 144: 5594-5605. PMID: 35311258, PMCID: PMC10331457, DOI: 10.1021/jacs.2c00874.Peer-Reviewed Original ResearchConceptsE3 ligase complexLigase complexProtein degradationReader proteinsMethyl readersE3 ligaseProteasomal degradationPROTAC designProtein levelsProteinLigand pairsDrug discovery paradigmPROTACsNatural mechanismGeneralizable approachComplexesDiscovery paradigmCUL4BRD2DegradationLigaseL3MBTL3FKBP12Biological evaluationPromising strategy
2021
Ultrasound-assisted Lumbar Puncture for Obese Pediatric Oncology Patients: A Feasibility Study
Leviter J, Kadan-Lottick NS, Auerbach C, Riera A. Ultrasound-assisted Lumbar Puncture for Obese Pediatric Oncology Patients: A Feasibility Study. Journal Of Pediatric Hematology/Oncology 2021, 44: 438-441. PMID: 34862351, DOI: 10.1097/mph.0000000000002362.Peer-Reviewed Original ResearchConceptsPediatric oncology patientsLumbar punctureOncology patientsStandard of carePediatric oncology providersSuccessful lumbar punctureDelivery of careUltrasound-assisted lumbar punctureLP successOncology providersDeep sedationHigh success rateCare ultrasoundTherapeutic interventionsPatientsPromising modalitySuccess rateLP procedurePunctureCarePromising strategyMost casesLow numberObesitySedation
2020
Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectives
Jamwal S, Elsworth JD, Rahi V, Kumar P. Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectives. Expert Review Of Neurotherapeutics 2020, 20: 1123-1141. PMID: 32720531, DOI: 10.1080/14737175.2020.1801424.Peer-Reviewed Original ResearchConceptsGene therapyClinical trialsDisease-modifying therapiesMutant huntingtinTreatment of HDAntibody-based therapiesPotential therapeutic interventionsNew therapeutic targetsGene-based therapiesImmune activationClinical dataImmunotherapyTherapeutic targetFunctional restorationTherapeutic interventionsTherapyHD pathogenesisMHTT proteinRecent updatesFuture perspectivesPromising strategyTrialsCurrent statusConsiderable attentionHDA Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Dash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsSecretory functionHuman-induced pluripotent stem cellsParacrine secretionMuscle cellsCollagen fibrillar densitiesSecretory factorsVascular regenerationWound healingTissue-engineered vascular graftsHealingVascular graftsStem cellsPluripotent stem cellsCollagen scaffoldsScaffold propertiesScaffold materialsCellsPromising strategyDisease modelingFibrillar densityRegenerative wound healingCytokinesGraft
2019
Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells
Nguyen T, Ho M, Kim K, Yun S, Mizar P, Easton J, Lee S, Kim K. Suppression of the Ubiquitin Pathway by Small Molecule Binding to Ubiquitin Enhances Doxorubicin Sensitivity of the Cancer Cells. Molecules 2019, 24: 1073. PMID: 30893775, PMCID: PMC6471062, DOI: 10.3390/molecules24061073.Peer-Reviewed Original ResearchConceptsCongo redUbiquitin processing enzymesAnticancer drugsDiazo compoundsNovel anticancer drugsSmall moleculesActivity of ubiquitinNMR mappingDevelopment of inhibitorsSurface of ubiquitinConventional anticancer drugsMoleculesDruggabilityUbiquitin moleculesPromising strategyRecognition sitesProof of conceptCompoundsRedSensitizersHereinBindingBinding of ubiquitinChemicalsScaffolds
2017
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N‑Methyl‑d‑aspartate (NMDA) Receptor Antagonist
Gynther M, Silvestri I, Hansen J, Hansen K, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering D, Bunch L. Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N‑Methyl‑d‑aspartate (NMDA) Receptor Antagonist. Journal Of Medicinal Chemistry 2017, 60: 9885-9904. PMID: 29205034, PMCID: PMC5788303, DOI: 10.1021/acs.jmedchem.7b01624.Peer-Reviewed Original ResearchConceptsMurine hepatocellular carcinoma cellsHepatocellular carcinoma cellsN-methyl-D-aspartate receptor antagonistCompetitive N-methyl-D-aspartate (NMDA) receptor antagonistMultidrug resistanceCarcinoma cellsCancer cellsCommon solid tumorsNMDA receptor inhibitionIntrinsic multidrug resistanceReceptor antagonistReceptor inhibitionAnticancer drug efficacyUnderlying biological mechanismsSolid tumorsDrug efficacyReduced expressionCytotoxic actionSorafenibStructure-activity studiesMDR transportersAnticancer drugsBiological mechanismsCellsPromising strategyDegradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir
Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials 2017, 144: 144-154. PMID: 28829952, PMCID: PMC5581224, DOI: 10.1016/j.biomaterials.2017.08.029.Peer-Reviewed Original ResearchConceptsPolymer carrierPolymeric nanoparticlesIntravaginal deliveryBioadhesive nanoparticlesNanoparticlesHuman immunodeficiency virusPromising strategyProtective mucus layerReproductive tractFormulation 1Residence timePolyEpithelial cell populationsSite of actionImmunodeficiency virusRetentionIntravaginal administrationVaginal lumenMucosal surfacesSustained protectionTopical applicationSTD epidemicsElvitegravirHormone cyclesMucus layerA Shared Decision-Making Intervention to Guide Opioid Prescribing After Cesarean Delivery
Prabhu M, McQuaid-Hanson E, Hopp S, Burns SM, Leffert LR, Landau R, Lauffenburger JC, Choudhry NK, Kaimal A, Bateman BT. A Shared Decision-Making Intervention to Guide Opioid Prescribing After Cesarean Delivery. Obstetrics And Gynecology 2017, 130: 42-46. PMID: 28594762, PMCID: PMC5482786, DOI: 10.1097/aog.0000000000002094.Peer-Reviewed Original ResearchConceptsCesarean deliveryDecision-making interventionLeftover opioid medicationsNumber of opioidsNumber of tabletsPain resolutionPostcesarean painOpioid medicationsOpioid prescribingOpioid useOxycodone tabletsMedian numberWomenPrescribingPrescriptionComputer-based decision aidDeliveryInterventionDecision aidStandard prescriptionPromising strategyHospitalizationMedicationsOpioidsPain
2016
Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles
Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J. Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine Nanotechnology Biology And Medicine 2016, 12: 1833-1842. PMID: 27039220, PMCID: PMC5045320, DOI: 10.1016/j.nano.2016.03.005.Peer-Reviewed Original ResearchConceptsDrug deliveryTargeted Drug DeliveryIschemic strokeNanoparticlesDelivery efficiencyTargeting approachesIschemic microenvironmentBlood-brain barrier permeabilityBlood-brain barrierCurrent drug treatmentPotential therapeutic agentPromising strategyInfarct volumeNEP1-40Clinical managementLeading causeBarrier permeabilitySubsequent administrationDrug treatmentStrokeTherapeutic agentsEnhanced survivalDeliveryEfficiencyMicroenvironmentEnhancing intracranial delivery of clinically relevant non-viral gene vectors
Berry S, Mastorakos P, Zhang C, Song E, Patel H, Suk J, Hanes J. Enhancing intracranial delivery of clinically relevant non-viral gene vectors. RSC Advances 2016, 6: 41665-41674. PMID: 27642512, PMCID: PMC5019568, DOI: 10.1039/c6ra01546h.Peer-Reviewed Original ResearchGene vectorsDNA nanoparticlesTransgene expressionNon-viral gene delivery platformNon-viral gene vectorsHigh-level transgene expressionGene delivery platformPolyethylene glycolSafe transfectionPEG coatingDelivery platformGene therapyEllipsoidal morphologyNanoparticlesCellular uptakeSubsequent transfectionAlkyne-azide cycloadditionPromising strategyConventional therapeuticsUniform distributionPlatformRapid diffusionEffective targetingDeliveryIntracranial delivery
2012
Ovarian cryopreservation.
Jeong K, Aslan E, Ozkaya E, Sonmezer M, Oktay K. Ovarian cryopreservation. Minerva Medica 2012, 103: 37-46. PMID: 22278067.Peer-Reviewed Original ResearchConceptsFertility preservationOvarian tissueNon-malignant diseasesFuture autotransplantationOvarian cryopreservationOvarian failurePrepubertal girlsReproductive endocrinologistsMalignant cellsTeam approachWhole ovariesHeterotopic locationNew promising strategyAutotransplantationSignificant delayDiseaseTissue piecesTissuePromising strategySlow freezingChemotherapyLaparoscopyPatientsEndocrinologistsOncologists
2009
Clinical trials for pathogen reduction in transfusion medicine: A review
McClaskey J, Xu M, Snyder EL, Tormey CA. Clinical trials for pathogen reduction in transfusion medicine: A review. Transfusion And Apheresis Science 2009, 41: 217-225. PMID: 19793679, DOI: 10.1016/j.transci.2009.09.008.Peer-Reviewed Original ResearchConceptsClinical trialsBlood productsDonor screening programsDonor blood productsRisk of transmissionInfective donorsTransfusion recipientsScreening programClinical settingInfectious diseasesTransfusion medicineTesting regimensPI treatmentTrialsScreening assaysRiskPathogensPotential toxicityPromising strategyDetection of pathogensRegimensPathogen reductionSensitive methodDiseaseRecipients
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