Enhancing intracranial delivery of clinically relevant non-viral gene vectors
Berry S, Mastorakos P, Zhang C, Song E, Patel H, Suk J, Hanes J. Enhancing intracranial delivery of clinically relevant non-viral gene vectors. RSC Advances 2016, 6: 41665-41674. PMID: 27642512, PMCID: PMC5019568, DOI: 10.1039/c6ra01546h.Peer-Reviewed Original ResearchGene vectorsDNA nanoparticlesTransgene expressionNon-viral gene delivery platformNon-viral gene vectorsHigh-level transgene expressionGene delivery platformPolyethylene glycolSafe transfectionPEG coatingDelivery platformGene therapyEllipsoidal morphologyNanoparticlesCellular uptakeSubsequent transfectionAlkyne-azide cycloadditionPromising strategyConventional therapeuticsUniform distributionPlatformRapid diffusionEffective targetingDeliveryIntracranial delivery
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