2016
Enhancing intracranial delivery of clinically relevant non-viral gene vectors
Berry S, Mastorakos P, Zhang C, Song E, Patel H, Suk J, Hanes J. Enhancing intracranial delivery of clinically relevant non-viral gene vectors. RSC Advances 2016, 6: 41665-41674. PMID: 27642512, PMCID: PMC5019568, DOI: 10.1039/c6ra01546h.Peer-Reviewed Original ResearchGene vectorsDNA nanoparticlesTransgene expressionNon-viral gene delivery platformNon-viral gene vectorsHigh-level transgene expressionGene delivery platformPolyethylene glycolSafe transfectionPEG coatingDelivery platformGene therapyEllipsoidal morphologyNanoparticlesCellular uptakeSubsequent transfectionAlkyne-azide cycloadditionPromising strategyConventional therapeuticsUniform distributionPlatformRapid diffusionEffective targetingDeliveryIntracranial delivery
2015
Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain
Mastorakos P, Song E, Zhang C, Berry S, Park H, Kim Y, Park J, Lee S, Suk J, Hanes J. Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain. Small 2015, 12: 678-685. PMID: 26680637, PMCID: PMC4913277, DOI: 10.1002/smll.201502554.Peer-Reviewed Original ResearchConceptsDNA nanoparticlesHigh-level transgene expressionTransgene expressionGene delivery platformSuccessful gene therapyConventional gene vectorsBrain-penetrating nanoparticlesPolyethylene glycol (PEG) coronaWidespread gene deliveryNanoparticle platformGene deliveryGene vectorsNanoparticlesDelivery platformGene therapyStable subTransgene expression patternsBiodegradable polymersConvection-enhanced deliveryPressure-driven flowDeliveryPlatformExtracellular matrixPromiseSteric hindranceHydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Mastorakos P, Kambhampati S, Mishra M, Wu T, Song E, Hanes J, Kannan R. Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells. Nanoscale 2015, 7: 3845-3856. PMID: 25213606, PMCID: PMC4797994, DOI: 10.1039/c4nr04284k.Peer-Reviewed Original ResearchConceptsTransgene deliveryGene vectorsNon-viral gene vectorsHigh-level transgene expressionNon-viral gene deliveryGene delivery platformGene-based therapeuticsOcular gene therapyGene deliveryColloidal stabilityNumerous blinding disordersGene therapyRetinal pigment epitheliumTransgene expressionHuman RPE cellsDNA complexationVector surfacePolyamidoamine dendrimersCell uptakePEGylated dendrimersTriamcinolone acetonideImproved stabilityRPE cellsAmine groupsInherent drawbacks
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