Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States
Ishchenko Y, Novosolova N, Khafizov K, Bart G, Timonina A, Fayuk D, Skorinkin A, Giniatullin R. Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States. Biochemistry 2017, 56: 3394-3402. PMID: 28616989, DOI: 10.1021/acs.biochem.7b00258.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBinding SitesBiological Transport, ActiveComputer SimulationFluorescent DyesHEK293 CellsHumansKineticsLigandsModels, MolecularPatch-Clamp TechniquesPoint MutationProtein Interaction Domains and MotifsProtein StabilityPurinergic P2X Receptor AgonistsPurinergic P2X Receptor AntagonistsRatsReceptors, Purinergic P2X7Recombinant ProteinsSerineConceptsRat P2X7 receptorP2X7 receptorSerine 288Novel phenotypesCorresponding residuesPosition 288MM ATPHuman P2X7 receptorMolecular modeling dataF288Agonist bindingATPReceptor statesP2X receptorsReceptor desensitizationPhenotypeATP concentrationFast deactivation ratesResiduesReceptorsKey roleS applicationMutantsSerineWT values
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