ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection
Liang C, Zhai T, Chen J, Fang S, Zhu Y, Liu L, Yu N, Zhao H. ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421995122. PMID: 40540593, PMCID: PMC12207453, DOI: 10.1073/pnas.2421995122.Peer-Reviewed Original ResearchConceptsCochlear efferent systemHearing sensitivityATP-gated P2X7 receptorP2X7 receptorOuter hair cellsAuditory nerveInnervate outer hair cellsEfferent systemAuditory brainstem responseSpiral ganglion (SGActive cochlear amplificationActive cochlear mechanicsEfferent nervesP2X7 KO miceIncreased susceptibility to noiseSusceptibility to noiseNeuronal functionAcoustic startle responseHair cellsBrainstem responseHearing lossEfferent suppressionHearing disordersOHC electromotilityNoise exposure
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