2016
090 Aspirin Does Not Have a Significant Impact on Loop Diuretic Response or Renin Release in Heart Failure Patients
Broughton J, Hanberg J, Assefa M, Rao V, Testani J. 090 Aspirin Does Not Have a Significant Impact on Loop Diuretic Response or Renin Release in Heart Failure Patients. Journal Of Cardiac Failure 2016, 22: s34-s35. DOI: 10.1016/j.cardfail.2016.06.108.Peer-Reviewed Original Research
2014
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. The FASEB Journal 2014, 29: 61-69. PMID: 25318477, PMCID: PMC4285537, DOI: 10.1096/fj.14-261867.Peer-Reviewed Original ResearchConceptsRenin releaseRenin-angiotensin systemMast cellsVentricular fibrillationRas activationHMC-1Murine bone marrow-derived mast cellsLocal renin-angiotensin systemBone marrow-derived mast cellsCardiac mast cellsNovel cardioprotective roleMarrow-derived mast cellsPurinergic P2X7 receptorIschemia/reperfusionHeart mast cellsCD39 inhibitionCD39 overexpressionP2X7R blockadeNorepinephrine overflowCardioprotective effectsCardioprotective roleP2X7 receptorCD39Pharmacological inhibitionATP release
2010
Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells. Circulation 2010, 122: 771-781. PMID: 20697027, PMCID: PMC2927811, DOI: 10.1161/circulationaha.110.952481.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAnimalsArrhythmias, CardiacCell DegranulationCell Line, TumorEnzyme ActivationGuinea PigsHumansIschemic Preconditioning, MyocardialMaleMast CellsMyocardial Reperfusion InjuryMyocytes, CardiacProtein Kinase C-epsilonReceptor, Adenosine A2BReceptor, Adenosine A3ReninRenin-Angiotensin SystemConceptsCardiac mast cellsAnti-RA effectRenin-angiotensin systemAldehyde dehydrogenase type 2Ischemic preconditioningIschemia/reperfusionMast cellsRenin releaseALDH2 activationReperfusion arrhythmiasNorepinephrine releaseRas activationHMC-1Local renin-angiotensin systemBlockade of adenosineLocal RAS activationClassic ischemic preconditioningDehydrogenase type 2New therapeutic targetsCultured mast cellsPKCepsilon inhibitionFibrillation durationMyocardial ischemiaVentricular tachycardiaHearts ex vivoInteraction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction
Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction. Journal Of Pharmacology And Experimental Therapeutics 2010, 335: 76-84. PMID: 20668055, PMCID: PMC2957783, DOI: 10.1124/jpet.110.172262.Peer-Reviewed Original ResearchMeSH KeywordsAldehydesAnimalsArrhythmias, Cardiacbeta-N-AcetylhexosaminidasesCalcitonin Gene-Related PeptideCell DegranulationCells, CulturedFluorescent Antibody TechniqueGuinea PigsIn Vitro TechniquesMaleMast CellsMyocardial Reperfusion InjuryMyocardiumNerve EndingsNerve Fibers, UnmyelinatedNorepinephrineReninRenin-Angiotensin SystemSensory Receptor CellsSubstance PSynaptosomesConceptsRenin-angiotensin systemIschemia/reperfusionCardiac mast cellsSubstance P receptor blockadeLocal renin-angiotensin systemSubstance PMast cellsSensory nervesCultured mast cellsRenin releaseReceptor blockadeCardiac dysfunctionLocal cardiac renin-angiotensin systemCardiac renin-angiotensin systemCardiac nerve terminalsCardiac sensory nervesMast cell reninSubstance P releaseSensory C-fibersMast cell stabilizationSubstance P receptorCardiac synaptosomesReperfusion arrhythmiasNorepinephrine overflowAngiotensin production
2008
Macula densa cells detect altered tissue metabolism via succinate and GPR91
Vargas S, Toma I, Kang J, Hanner F, Peti‐Peterdi J. Macula densa cells detect altered tissue metabolism via succinate and GPR91. The FASEB Journal 2008, 22: 761.17-761.17. DOI: 10.1096/fasebj.22.1_supplement.761.17.Peer-Reviewed Original ResearchDiabetes mellitusMacula densaMMDD1 cellsJuxtaglomerular apparatusCOX-2Ras activationRenin-angiotensin system activationGlomerular filtration rateEarly diabetes mellitusMacula densa cellsRelease of PGE2Tubular fluid compositionRenin releaseRenin contentFiltration rateMD cellsSTZ-DMJG cellsMetabolic factorsPGE2 releaseSystem activationMetabolic receptorsReceptor GPR91GPR91 activationTubular fluid
2007
GPR91 triggers paracrine signaling in the JGA
Toma I, Kang J, Bansal E, Sipos A, McCulloch F, Peti‐Peterdi J. GPR91 triggers paracrine signaling in the JGA. The FASEB Journal 2007, 21: a498-a498. DOI: 10.1096/fasebj.21.5.a498-b.Peer-Reviewed Original ResearchGlomerular endothelial cellsVascular smooth muscleJuxtaglomerular apparatusRenin releaseJG cellsFura-2PGE2 receptors EP1Early diabetic nephropathyAction of PGE2Fura-2 fluorescenceDiabetic nephropathyReceptor blockadeEndothelial calciumReceptor EP1COX inhibitionNOS activationSignificant elevationSmooth muscleParacrine signaling mechanismKnockout micePGE2 releaseMetabolic receptorsGPR91SiRNA treatmentCytosolic calcium
1991
Effects of endothelin on in vitro renin secretion
Moe O, Tejedor A, Campbell WB, Alpern RJ, Henrich WL. Effects of endothelin on in vitro renin secretion. American Journal Of Physiology 1991, 260: e521-e525. PMID: 2018117, DOI: 10.1152/ajpendo.1991.260.4.e521.Peer-Reviewed Original ResearchConceptsRat kidney cortical slicesRenin secretionKidney cortical slicesEndothelin-1Juxtaglomerular cellsRenin releaseCortical slicesRenin inhibitionBasal renin releaseVitro renin secretionBasal renin secretionRenal renin secretionEffects of endothelinIntracellular calcium bufferAddition of isoproterenolMechanism of actionRenin inhibitorsIsoproterenolSecretionCalcium bufferDistinct preparationsBAPTASimilar effectsDirect effectInhibition
1990
Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine.
Brown NJ, Porter J, Ryder D, Branch RA. Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine. Journal Of Pharmacology And Experimental Therapeutics 1990, 256: 56-61. PMID: 1988669, DOI: 10.1016/s0022-3565(25)23205-0.Peer-Reviewed Original ResearchConceptsRenin responseEndogenous adenosineRenin releaseDiazoxide infusionAdenosine inhibitsRegulation of reninCross-over studyAdministration of diazoxideAdenosine receptor blockerModest tachycardiaPRA responseReceptor blockersBP responseLoading dosePRA measurementsContinuous infusionNormal subjectsStudy daysDiazoxideMaximal pulseInfusionPresence of caffeineReninCaffeineAdenosine
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