2025
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions
Gansau J, Grossi E, Rodriguez L, Wang M, Laudier D, Chaudhary S, Hecht A, Fu W, Sebra R, Liu C, Iatridis J. TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions. Osteoarthritis And Cartilage 2025, 33: 874-887. PMID: 40139648, PMCID: PMC12146073, DOI: 10.1016/j.joca.2025.02.791.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnnulus FibrosusCells, CulturedCellular SenescenceCulture Media, ConditionedFemaleHumansIntervertebral DiscIntervertebral Disc DegenerationMaleMiddle AgedReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISignal TransductionTumor Necrosis Factor-alphaConceptsTNFR2 signalingConditioned mediumInflammatory responseIVD cellsHuman annulus fibrosusDelivery of macrophagesPainful intervertebral discIntervertebral discAttenuated inflammatory responsePro-inflammatory responseNO effectHuman IVD cellsHuman annulus fibrosus cellsReduced metabolic rateReceptor 2Cytokine mixtureMacrophage populationsHAFS cellsInflammatory proteinsMetabolic impairmentBulk RNA-seqIntervertebral disc repairMetabolic rateCell cycle stateAutopsy subjects
2024
Pre‐diagnostic plasma inflammatory proteins and risk of hepatocellular carcinoma in three population‐based cohort studies from the United States and the United Kingdom
Zhao L, Zhang X, Birmann B, Danford C, Lai M, Simon T, Chan A, Giovannucci E, Ngo L, Libermann T, Zhang X. Pre‐diagnostic plasma inflammatory proteins and risk of hepatocellular carcinoma in three population‐based cohort studies from the United States and the United Kingdom. International Journal Of Cancer 2024, 155: 1593-1603. PMID: 38861327, PMCID: PMC11537828, DOI: 10.1002/ijc.35054.Peer-Reviewed Original ResearchConceptsHealth Professionals Follow-up StudyNurses' Health StudyAssociated with riskOdds ratioStatistical significance thresholdRisk of hepatocellular carcinomaHepatocellular carcinoma riskUK BiobankPopulation-based cohort studyConfidence intervalsMultivariate odds ratiosNested Case-Control StudyConditional logistic regressionHepatocellular carcinomaIncident HCC casesPre-diagnostic plasmaCase-control studyInflammatory proteinsHealth StudyAssociated with risk of hepatocellular carcinomaCohort studyGeneral populationLogistic regressionHepatocellular carcinoma etiologiesFollow-up study
2011
Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*
Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*. Journal Of Biological Chemistry 2011, 286: 34976-34985. PMID: 21816823, PMCID: PMC3186354, DOI: 10.1074/jbc.m111.241547.Peer-Reviewed Original ResearchConceptsVpr proteinHIV-1HIV-1-infected target cellsNeuronal dysfunctionHIV-1 Vpr proteinHIV-infected patientsInfection of neuronsEndoplasmic reticulum calcium releaseNeurocognitive disordersDeregulation of calcium homeostasisViral protein ROxidative stress pathwaysGene array assayHuman neuronal cell lineNeuronal cell lineDevelopment of neurocognitive disordersProtein RTarget cellsCalcium homeostasisSynaptic retractionInflammatory proteinsArray assayCell linesHuman neuronsDysfunction
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