2025
The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study
Liu X, Zhang X, Zhao L, Petrick J, Liao L, Wang W, He N, Giovannucci E, Zhang Z, McGlynn K, Zhang X. The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study. American Journal Of Clinical Nutrition 2025, 122: 263-273. PMID: 40306387, PMCID: PMC12308092, DOI: 10.1016/j.ajcnut.2025.04.028.Peer-Reviewed Original ResearchConceptsChronic liver disease mortalityHigh-fat dairyLiver cancer incidenceTotal dairy intakeLow-fat dairyAssociated with intakeAssociated with riskDairy intakeCancer incidenceIncident liver cancer casesIntakes of high-fat dairyHigh-fat dairy intakeHealth Study cohortLiver disease mortalitySelf-administered validated questionnairePre-existing cancer diagnosisIntake of dairy productsLiver cancer riskLow-fat dairy productsChronic liver diseaseHigh-fat milkAssociated with liver cancerLow-fat milkProspective cohort studyCox proportional hazards models
2024
Ultra-processed products and risk of liver cancer: A prospective cohort study
Zhao L, Zhang X, Yu D, Wang L, Shrubsole M, Zheng W, Sudenga S, Zhang X. Ultra-processed products and risk of liver cancer: A prospective cohort study. Clinical Nutrition 2024, 43: 2298-2304. PMID: 39226717, PMCID: PMC11479389, DOI: 10.1016/j.clnu.2024.08.011.Peer-Reviewed Original ResearchConceptsUltra-processed foodsRisk of liver cancerUltra-processed productsLiver cancer riskCancer riskAssociated with liver cancer riskIntake of ultra-processed foodsIncident liver cancer casesSouthern Community Cohort StudyHigher risk of liver cancerCohort studyYear Follow-UpElevated risk of liver cancerElevated riskIncident liver cancerState Cancer RegistryNational Death IndexCommunity Cohort StudyFood frequency questionnaireLiver cancerProspective cohort studyHigh riskLiver cancer casesNOVA classificationCancer RegistryDiabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium
Ho N, Abe S, Rahman S, Islam R, Saito E, Gupta P, Pednekar M, Sawada N, Tsugane S, Tamakoshi A, Kimura T, Shu X, Gao Y, Koh W, Cai H, Wen W, Sakata R, Tsuji I, Malekzadeh R, Pourshams A, Kanemura S, Kim J, Chen Y, Ito H, Oze I, Nagata C, Wada K, Sugawara Y, Park S, Shin A, Yuan J, Wang R, Kweon S, Shin M, Poustchi H, Vardanjani H, Ahsan H, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D, Boffetta P. Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium. International Journal Of Cancer 2024, 155: 854-870. PMID: 38661292, DOI: 10.1002/ijc.34965.Peer-Reviewed Original ResearchLiver cancer incidenceAsia Cohort ConsortiumBaseline diabetesCancer incidenceCohort ConsortiumAssociated with increased liver cancer riskMortality of liver cancerHazard ratioLiver cancer mortalityTwo-stage meta-analysisLiver cancer riskMeta-analysisCox proportional hazards modelsBody mass indexFollow-up timeProportional hazards modelCancer mortalityCancer riskTobacco smokeBaseline ageCumulative incidence of deathCancer diagnosisCohort studyMeta-analytic approachMass indexLong-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study
Ma X, Fisher J, McGlynn K, Liao L, Vasiliou V, Sun N, Kaufman J, Silverman D, Jones R. Long-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study. Environment International 2024, 187: 108637. PMID: 38636274, PMCID: PMC11286199, DOI: 10.1016/j.envint.2024.108637.Peer-Reviewed Original ResearchConceptsRisk of liver cancerIncreased risk of liver cancerFine particulate matterNIH-AARP DietNIH-AARPParticulate matterHistorical PM<sub>2.5</sub> concentrationsOutdoor PM<sub>2.5</sub> levelsAmbient PM<sub>2.5</sub> levelsLong-term exposure to ambient fine particulate matterHealth StudyExposure to ambient fine particulate matterAmbient fine particulate matterAssociated with liver cancer riskYears prior to cancer diagnosisEvidence of effect modificationLiver cancer riskLiver cancer incidenceIncreased riskSpatiotemporal prediction modelAmbient PM2.5 levelsPM2.5 levelsHistorical exposure assessmentBody mass indexPhysical activity
2023
Liver cancer risk quantification through an artificial neural network based on personal health data
Ataei A, Deng J, Muhammad W. Liver cancer risk quantification through an artificial neural network based on personal health data. Acta Oncologica 2023, 62: 495-502. PMID: 37211681, DOI: 10.1080/0284186x.2023.2213445.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyLiver cancer riskHealth dataCancer riskHealth Interview SurveyHepatocellular carcinomaPersonal health dataHigh-risk populationLiver cancerInterview SurveyReceiver operating characteristic curveArea under the receiver operating characteristic curveCancer-related deathsPrimary liver cancerHealthOvarian cancerTherapeutic optionsMalignant diseaseTest cohortEarly detectionAggressive progressionRiskCancerCharacteristic curveLiver
2022
Specific botanical groups of fruit and vegetable consumption and liver cancer and chronic liver disease mortality: a prospective cohort study
Zhao L, Jin L, Petrick J, Zeng H, Wang F, Tang L, Smith-Warner S, Eliassen A, Zhang F, Campbell P, Giovannucci E, Liao L, McGlynn K, Steck S, Zhang X. Specific botanical groups of fruit and vegetable consumption and liver cancer and chronic liver disease mortality: a prospective cohort study. American Journal Of Clinical Nutrition 2022, 117: 278-285. PMID: 36811575, PMCID: PMC10131619, DOI: 10.1016/j.ajcnut.2022.12.004.Peer-Reviewed Original ResearchConceptsChronic liver disease mortalityHigher intake of total vegetablesIntake of total vegetablesRisk of liver cancerTotal vegetablesVegetable intakeHigher intakeNational Institutes of Health-American Association of Retired Persons DietInverse associationChronic liver disease deathsChronic liver diseaseHazard ratioIncident liver cancerLiver disease mortalityConfidence intervalsIntake of lettuceMultivariable hazard ratiosLiver cancer riskLiver cancer incidenceFood frequency questionnaireCox proportional hazards regressionAssociated with liver cancerProspective cohort studyProportional hazards regressionVegetable consumptionAssociation Between Sugar-Sweetened Beverage Intake and Liver Cancer Risk in the Women’s Health Initiative
Zhao L, Coday M, Garcia D, Li X, Lopez-Pentecost M, Manson J, McGlynn K, Mossavar-Rahmani Y, Naughton M, Saquib N, Sesso H, Shadyab A, Simon M, Snetselaar L, Tabung F, Tinker L, Tobias D, VoPham T, Zhang X. Association Between Sugar-Sweetened Beverage Intake and Liver Cancer Risk in the Women’s Health Initiative. Current Developments In Nutrition 2022, 6: 259. PMCID: PMC9193518, DOI: 10.1093/cdn/nzac052.026.Peer-Reviewed Original ResearchSugar-sweetened beverage intakeSugar-sweetened beveragesRisk of liver cancerHigher SSB intakeHistory of diabetesSSB intakeIntake of sugar-sweetened beveragesNon-statistically significant positive associationWomen's Health Initiative Observational StudyFruit drinksHazard ratioIncident liver cancerSoft drinksConfidence intervalsMultivariable hazard ratiosLiver cancer riskWomen's Health InitiativeFood frequency questionnaireRisk factorsModifiable risk factorsSelf-administered questionnaireMedical record reviewNon-steroidal anti-inflammatory drug useCox proportional hazards regression modelsProportional hazards regression models
2021
Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies
Zhao L, Deng C, Lin Z, Giovannucci E, Zhang X. Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies. Cancers 2021, 13: 1580. PMID: 33808094, PMCID: PMC8037522, DOI: 10.3390/cancers13071580.Peer-Reviewed Original ResearchLiver cancer riskMeta-analysis of prospective studiesRisk of liver cancerCancer riskIntake of dietary saturated fatty acidsDietary saturated fatty acidsDose-response analysisProspective studyAssociated with higher risk of liver cancerHigher intakeHigher risk of liver cancerBetween-study variabilitySystematic reviewDietary fatLiver cancerSerum levelsHigh liver cancer riskHigher serum total cholesterolMeta-analysisSerum high-density lipoprotein (HDL) cholesterolHigh-density lipoprotein (HDL) cholesterolAssociated with liver cancerAssociated with higher riskSerum cholesterolHigher serum levels
2018
Association between insulin therapy and risk of liver cancer among diabetics
Liu X, Wu H, Zhao L, Xu H, Zhang W, Xiang Y. Association between insulin therapy and risk of liver cancer among diabetics. European Journal Of Gastroenterology & Hepatology 2018, 30: 1-8. PMID: 29064852, DOI: 10.1097/meg.0000000000001001.Peer-Reviewed Original ResearchConceptsRisk of liver cancerCohort studyInsulin useReducing liver cancer riskStudy-specific risksPotential public health benefitsEpidemiological studiesLiver cancer riskRelevant epidemiological studiesOverall relative riskMeta-analysisDuration of insulin usePrevalence of diabetesIncidence of liver cancerPublic health benefitsFollow-up yearCohort of diabetic patientsLiver cancer casesCase-control studyAssociated with elevated incidenceRandom-effects modelStatistically significant associationWeb of ScienceDiabetes mellitusCancer risk
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