2025
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, kfaf110. PMID: 40737496, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseLiver diseaseChronic ethanol intakeCentral mechanismsHepatotoxic effectsPolyfluoroalkyl substancesHigh-risk populationOxidative stressDysregulated lipid metabolismEthanol intakeLiver functionLiver injuryAcetaldehyde-induced cytotoxicityHepatic functionHepatocellular damageOxidative stress inductionLiver pathologyGlobal morbidityPathogenic pathwaysPolyfluoroalkyl substances exposuresExposure to polyfluoroalkyl substancesFatty acid oxidationHealthcare accessEffects of polyfluoroalkyl substancesMultiple mechanismsThe OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis.
Zhang L, Han C, Shrestha M, Le J, Berger W, Huang Y, Desrouleaux R, Wang E, Nagy L, Yang X. The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis. Hepatology 2025 PMID: 40587778, DOI: 10.1097/hep.0000000000001445.Peer-Reviewed Original ResearchMetabolic dysfunction-associated fatty liver diseaseTrefoil factor 2O-GlcNAc transferaseGubra-amylin NASHParacrine factorsCD4+ T cell proliferationLiver diseaseCD4 T cellsTreatment of chronic liver diseaseT cell proliferationChemokine ligand-12Chronic liver diseaseDiet-induced mouse modelSpectrum of liver pathologyFatty liver diseaseNon-parenchymal cellsTh1/Th17 differentiationO-GlcNAc transferase expressionT cellsDiet-fed miceImmune cellsDisease progressionMouse modelIntercellular crosstalkLiver pathologyMechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice
Wu Y, Lin R, Yuan Q, Sun Y, Yuan Y, Jiang T, Jiang J, Mu P, Wen J, Deng Y. Mechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice. Ecotoxicology And Environmental Safety 2025, 301: 118489. PMID: 40513317, DOI: 10.1016/j.ecoenv.2025.118489.Peer-Reviewed Original ResearchFarnesoid X receptorTotal bile acidsBile acidsFXR functionPro-inflammatory cytokine expressionPro-inflammatory cascadeDON-induced toxicityTarget of farnesoid X receptorEndoplasmic reticulum stressMurine modelUnfolded protein responseHepatocellular injuryNuclear receptor signalingCytokine expressionHepatic cholestasisHepatocellular damageReceptor signalingSignaling dysregulationLiver pathologyCholestasisPharmacological targetsCentral mechanismsTherapeutic targetSignaling AxisUpregulate pro-inflammatory cytokine expression
2024
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice
Bertolini A, Nguyen M, Zehra S, Taleb S, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice. Journal Of Hepatology 2024, 81: 429-440. PMID: 38554847, PMCID: PMC11347101, DOI: 10.1016/j.jhep.2024.03.041.Peer-Reviewed Original ResearchCystic fibrosis-related liver diseaseCystic fibrosis transmembrane conductance regulatorCFTR-KO miceDefective cystic fibrosis transmembrane conductance regulatorCFTR-KOIntestinal permeabilityLiver diseaseGut-liver axisGut dysbiosisIncreased morbidityMortality of CF patientsAssociated with increased intestinal permeabilityLiver pathologyDevelopment of cholangiopathyCftr-knockout miceTransmembrane conductance regulatorIncreased intestinal permeabilityTargeted therapeutic strategiesFecal microbiota transferAttenuates liver diseaseExcessive inflammatory responseFITC-dextran assayPresence of neutrophilsActivation of pro-inflammatoryCFTR-knockout
2023
The evolving role of liver sinusoidal endothelial cells in liver health and disease
McConnell M, Kostallari E, Ibrahim S, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology 2023, 78: 649-669. PMID: 36626620, PMCID: PMC10315420, DOI: 10.1097/hep.0000000000000207.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLiver diseaseAlcohol-associated liver diseaseEndothelial cellsLiver transplant rejectionIschemia-reperfusion injuryLiver sinusoidal endothelial cellsSinusoidal endothelial cellsPortal hypertensionLiver inflammationMicrovascular thrombosisViral hepatitisReperfusion injuryTransplant rejectionLiver healthLiver pathologyLiver homeostasisLiver regenerationQuiescent phenotypePathological processesUnique populationDiseaseLSECLiver biologyGene expression profilesInflammation
2022
Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group
Lohse AW, Sebode M, Bhathal PS, Clouston AD, Dienes HP, Jain D, Gouw ASH, Guindi M, Kakar S, Kleiner DE, Krech T, Lackner C, Longerich T, Saxena R, Terracciano L, Washington K, Weidemann S, Hübscher SG, Tiniakos D. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group. Liver International 2022, 42: 1058-1069. PMID: 35230735, DOI: 10.1111/liv.15217.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisChronic autoimmune hepatitisLobular hepatitisLymphoplasmacytic hepatitisInflammatory changesLiver diseaseHistological featuresHistological criteriaConsensus criteriaInternational consensus criteriaExpert liver pathologistsDelphi panel approachChronic presentationAcute presentationLiver biopsyHistological diagnosisHistopathological diagnosisLiver pathologistsLiver pathologyConsensus statementConsensus recommendationsHepatitisPathology groupDisease severityPeriportal region
2021
Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy
Chen S, Goldsmith J, Fawaz R, Al-Ibraheemi A, Perez-Atayde A, Vargas S. Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy. The American Journal Of Surgical Pathology 2021, 45: 1091-1097. PMID: 33756496, DOI: 10.1097/pas.0000000000001710.Peer-Reviewed Original ResearchConceptsCTE patientsCongenital tufting enteropathyParenteral nutritionBiliary epitheliumDuctular reactionLiver pathologyChronic hepatitis CHepatitis C patientsEpithelial cell adhesion moleculeLiver core biopsyIntestinal villous atrophyNormal brush borderClinicopathologic materialEpCAM-deficientCore biopsyTufting enteropathyC patientsEpCAM mutationsCell adhesion moleculesHepatitis CLiver biopsyMOC31Affected patientsLobular inflammationPathological findings
2020
Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice
Eguchi A, Yan R, Pan S, Wu R, Kim J, Chen Y, Ansong C, Smith R, Tempaku M, Ohno-Machado L, Takei Y, Feldstein A, Tsukamoto H. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. Journal Of Molecular Medicine 2020, 98: 1021-1034. PMID: 32556367, PMCID: PMC7810220, DOI: 10.1007/s00109-020-01926-7.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsAlcoholic liver diseaseAlcoholic hepatitisAH miceIL-1βHepatic macrophagesStellate cellsExtracellular vesiclesPrimary hepatic stellate cellsIL-17 upregulationIL-17 productionUpregulated IL-1βHepatocyte-derived extracellular vesiclesNovel murine modelTLR9-dependent mannerMacrophage IL-1βHepatitis miceIL-17Liver diseaseControl miceCytokine productionLiver pathologyLiver fibrogenesisMurine modelΑ-SMARecent Advances in Practical Methods for Liver Cell Biology: A Short Overview
Torres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J. Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview. International Journal Of Molecular Sciences 2020, 21: 2027. PMID: 32188134, PMCID: PMC7139397, DOI: 10.3390/ijms21062027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLiver cell biologyCell biologyLiver diseaseHepatocellular carcinomaHigh-throughput assaysNon-parenchymal liver cellsSophisticated animal modelsPortal hypertensionLiver pathologyCell isolation techniquesTherapeutic strategiesAnimal modelsStem cellsBiologyPreclinical testingVivo assessmentLiver cellsOrganoid researchVivo methodsNovel opportunitiesDiseaseResearch modalitiesCellsRecent advancesHypertension
2019
Targeting the site encoded by SERPINA1*E342K for treating alpha‐1 antitrypsin deficiency‐associated liver diseases
Zhang X, Pham K, Li D, Schutte RJ, Brantly M, Liu C, Ostrov DA. Targeting the site encoded by SERPINA1*E342K for treating alpha‐1 antitrypsin deficiency‐associated liver diseases. FEBS Letters 2019, 593: 1849-1862. PMID: 31116417, DOI: 10.1002/1873-3468.13452.Peer-Reviewed Original ResearchIdentification of key challenges in liver pathology: data from a multicenter study of extramural consults
Torbenson MS, Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh M. Identification of key challenges in liver pathology: data from a multicenter study of extramural consults. Human Pathology 2019, 87: 75-82. PMID: 30857968, DOI: 10.1016/j.humpath.2019.03.001.Peer-Reviewed Original ResearchConceptsLiver pathologyEtiology of cirrhosisFatty liver diseasePrimary biliary cirrhosisDiagnosis of malignancyFocal nodular hyperplasiaLiver casesAutoimmune hepatitisHepatitic patternBiliary cirrhosisLiver diseaseMetastatic malignancyMulticenter studyHepatic adenomaNodular hyperplasiaBenign tumorsConsult serviceMalignant tumorsHepatocellular carcinomaAcademic centersSpecific diagnosisTumor pathologyTumor typesConsultant diagnosesPatient care
2015
Oxidative Stress in Nonautoimmune Biliary Diseases
Cadamuro M, Fabris L, Strazzabosco M. Oxidative Stress in Nonautoimmune Biliary Diseases. Oxidative Stress In Applied Basic Research And Clinical Practice 2015, 309-324. DOI: 10.1007/978-3-319-15539-5_13.Peer-Reviewed Original Research
2013
Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis
Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology 2013, 58: 1713-1723. PMID: 23744610, PMCID: PMC3800498, DOI: 10.1002/hep.26554.Peer-Reviewed Original ResearchConceptsAutosomal recessive polycystic kidney diseaseCongenital hepatic fibrosisCaroli's diseaseΒ-cateninHepatic fibrosisRac-1 inhibitionIntrahepatic bile ductsRecessive polycystic kidney diseasePotential therapeutic targetPolycystic kidney diseaseStimulation of cAMPRac-1 activityE-cadherin expressionBile ductKidney diseaseLiver pathologyCystic dysplasiaMouse modelTherapeutic targetTranscriptional activityNuclear translocationDiseasePKA blockerCholangiocytesFibrosisGlutathione defense mechanism in liver injury: Insights from animal models
Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defense mechanism in liver injury: Insights from animal models. Food And Chemical Toxicology 2013, 60: 38-44. PMID: 23856494, PMCID: PMC3801188, DOI: 10.1016/j.fct.2013.07.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLiver injuryGlutamate-cysteine ligaseMouse modelLiver disease processTransgenic mouse modelCellular GSH concentrationGSH homeostasisLiver diseaseClinical stageHepatic insultLiver pathologyDisease processRate-limiting enzymeAnimal modelsHepatic GSHHepatic responseModifier subunitGenetic deficiencyInjuryPathophysiological functionsGSH deficitThiol antioxidantGSH concentrationMiceRole of GSH
2012
Sterile Inflammation in the Liver
Kubes P, Mehal WZ. Sterile Inflammation in the Liver. Gastroenterology 2012, 143: 1158-1172. PMID: 22982943, DOI: 10.1053/j.gastro.2012.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdenosine TriphosphateCaspase 1Chemical and Drug Induced Liver InjuryChemotaxis, LeukocyteCytokinesFatty LiverFatty Liver, AlcoholicHepatitisHMGB1 ProteinHumansInflammasomesInterleukin-1betaNeutrophilsNon-alcoholic Fatty Liver DiseaseNucleic AcidsReceptors, Pattern RecognitionReperfusion InjurySignal TransductionUric AcidConceptsDamage-associated molecular patternsPattern recognition receptorsImmune cellsSterile inflammationRecognition receptorsCellular pattern recognition receptorsDrug-induced liver injuryEndogenous damage-associated molecular patternsSuch damage-associated molecular patternsMolecular patternsSite of injuryPathogen-associated molecular patternsProtease caspase-1Alcoholic steatohepatitisLiver injuryNonalcoholic steatohepatitisLiver diseaseProinflammatory cytokinesSpecific therapyInterleukin-1βLiver pathologyTissue injuryImmune responseTherapeutic targetActivate receptors
2009
Evaluation of hepatic fibrosis with portal pressure gradient in rats
Wang Y, Booth CJ, Kim H, Qiu M, Constable RT. Evaluation of hepatic fibrosis with portal pressure gradient in rats. Magnetic Resonance In Medicine 2009, 61: 1185-1192. PMID: 19253377, PMCID: PMC11210607, DOI: 10.1002/mrm.21964.Peer-Reviewed Original ResearchConceptsHepatic fibrosisFibrosis scorePortal pressure gradientCirrhosis groupFibrosis groupLiver fibrosisLiver pathologyPortal veinHistological examinationAnimal studiesNoninvasive assessmentFibrosisNoninvasive meansGradient echo sequenceVessel areaSignificant differencesRatsContrast agentsEcho sequenceScoresCarbon tetrachlorideGroupPhantom study
2002
LIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION
Morotti R, Tata M, Drut R, Siminovich S, Menezes D, Gutierrez M, Kahn E. LIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION. Fetal And Pediatric Pathology 2002, 21: 79-87. DOI: 10.1080/pdp.21.1.79.87.Peer-Reviewed Original ResearchSA childrenGiant cell transformationTime of deathCases of childrenCytomegalovirus infectionPeliosis hepatisImmunodeficiency syndromeLymphoproliferative disordersOpportunistic infectionsPediatric hospitalHepatic changesLiver pathologyRapid progressionHigh prevalenceNA groupLiver tissueChildrenInfectionAIDSAmerican populationCell transformationNorth American populationsHepatisHistopathologicInflammationLIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION
Morotti R, Tata M, Drut R, Siminovich S, Menezes D, Gutierrez M, Kahn E. LIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION. Fetal And Pediatric Pathology 2002, 21: 79-87. DOI: 10.1080/15227950252774200.Peer-Reviewed Original Research
2001
LIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION
Morotti R, Tata M, Drut R, Siminovich S, Menezes D, Guitierrez M, Kahn E. LIVER PATHOLOGY IN CHILDREN WITH AIDS: A COMPARISON BETWEEN THE SOUTH AMERICAN AND NORTH AMERICAN POPULATION. Fetal And Pediatric Pathology 2001, 20: 537-545. PMID: 11699578, DOI: 10.1080/pdp.20.6.537.545.Peer-Reviewed Original ResearchConceptsSA childrenGiant cell transformationTime of deathCases of childrenPeliosis hepatisCytomegalovirus infectionLymphoproliferative disordersOpportunistic infectionsHepatic changesPediatric hospitalLiver pathologyRapid progressionHigh prevalenceNA groupLiver tissueAIDSChildrenInfectionAmerican populationCell transformationNorth American populationsHepatisHistopathologicInflammationGroup
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply