2015
Chapter 7 RNAi screens of lysosomal trafficking
Garg S, Brenner M. Chapter 7 RNAi screens of lysosomal trafficking. Methods In Cell Biology 2015, 126: 119-138. PMID: 25665444, DOI: 10.1016/bs.mcb.2014.10.030.Peer-Reviewed Original ResearchConceptsShort hairpin RNA screenRNA interference screenStudy lysosome functionCargo traffickingInterference screenTrafficking proteinsGene candidatesMammalian cellsArray screeningRNA screeningLysosomal functionMicrobial killingAssay developmentLysosomesScreening systemPresentation to T cellsAntigen presentation to T cellsRNATraffickingProteinVesiclesScreeningT cellsBiologyCentral position
2011
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b
Garg S, Sharma M, Ung C, Tuli A, Barral D, Hava D, Veerapen N, Besra G, Hacohen N, Brenner M. Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b. Immunity 2011, 35: 182-193. PMID: 21802320, PMCID: PMC3584282, DOI: 10.1016/j.immuni.2011.06.009.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAntigen PresentationAntigensAntigens, CD1dCytokinesCytotoxicity, ImmunologicHeLa CellsHumansLymphocyte ActivationLysosomesNatural Killer T-CellsProtein BindingProtein TransportProteolipidsrab GTP-Binding Proteinsrab7 GTP-Binding ProteinsRNA, Small InterferingVesicular Transport ProteinsConceptsHomotypic fusion and vacuole protein sortingGTPase Arl8bMicrobial killingVacuole protein sortingPhagosome-lysosome fusionCargo traffickingProtein sortingArl8bShRNA librarySilenced cellsLysosomal traffickingPlasma membraneMolecular regulationImmunological screeningHost defenseLysosomesTraffickingAntigen presentationT cell activationCargo deliveryRegulationKillingCell activationImmunological functionsEffector
1996
Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase
Malawista S, Montgomery R, van Blaricom G. Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase. Journal Of Leukocyte Biology 1996, 60: 753-757. PMID: 8975878, DOI: 10.1002/jlb.60.6.753.Peer-Reviewed Original ResearchConceptsNO synthase inhibitorSynthase inhibitorL-NIOMin of incubationMonomethyl-L-arginineNitric oxide synthaseHuman blood neutrophilsSimilar suppressive effectReactive nitrogen intermediatesL-Arg analoguesIrreversible inhibitorBlood neutrophilsOxide synthaseSuppressive effectKilling capacityL-arginineKilling pathwaysHuman neutrophilsL-ArgD-ArgNeutrophilsNitrogen intermediatesMicrobial killingGranule contentsIntact neutrophils
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