2025
Positron Emission Tomography Radiotracers for Identification of Site of Recurrence in Prostate Cancer After Primary Treatment Failure
Bitar R, Zurita P, Martiniova L, Zurita A, Ravizzini G. Positron Emission Tomography Radiotracers for Identification of Site of Recurrence in Prostate Cancer After Primary Treatment Failure. Cancers 2025, 17: 1723. PMID: 40427220, PMCID: PMC12109795, DOI: 10.3390/cancers17101723.Peer-Reviewed Original ResearchProstate-specific membrane antigenProstate-specific antigenProstate cancerPositron emission tomographyPositron emission tomography radiotracersBiochemical recurrenceF-FDGUpregulation of amino acid transportersProstate-specific membrane antigen expressionBiochemical recurrence of prostate cancerInvestigate positron emission tomographySerum prostate-specific antigenRecurrence of prostate cancerPrimary treatment failurePSMA-targeted agentsSite of recurrencePrimary prostate cancerSalvage therapyF-fluciclovineLocalized diseaseTreatment failureDefinitive managementMembrane antigenInvestigational agentsRadionuclide therapy
2024
Emerging Novel Functional Imaging and Immunotherapy in Renal Cell Carcinoma and Current Treatment Sequencing Strategies After Immunotherapy.
Ali M, Eid M, Saliby R, Choi S, McKay R, Siva S, Braun D, Chen Y. Emerging Novel Functional Imaging and Immunotherapy in Renal Cell Carcinoma and Current Treatment Sequencing Strategies After Immunotherapy. American Society Of Clinical Oncology Educational Book 2024, 44: e438658. PMID: 38875505, DOI: 10.1200/edbk_438658.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaTreatment sequencing strategiesCell carcinomaImmune checkpoint inhibitors targeting PD-1Chimeric antigen receptor T-cell therapyCheckpoint inhibitors targeting PD-1Management of renal cell carcinomaAdvanced renal cell carcinomaProstate-specific membrane antigenLandscape of renal cell carcinomaRCC-associated antigensImmune checkpoint inhibitionT-cell therapyPrimary kidney tumorsAssess treatment responseChanging treatment landscapeCarbonic anhydrase IXFunctional imagingFunctional imaging modalitiesCheckpoint inhibitionPD-1Immunotherapy strategiesLAG-3Membrane antigenT cells
2017
A phase 1/1b multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, pharmacokinetics, immunogenicity, and antitumor activity of MEDI3726 in patients with metastatic, castration-resistant prostate cancer who have received prior treatment with abiraterone or enzalutamide.
Fleming M, Cathomas R, Petrylak D, Wang J, Bander N, Zammarchi F, van Berkel P, Cho S, Elgeioushi N, Bothos J, Scheuber A, de Bono J. A phase 1/1b multicenter, open-label, dose escalation and dose expansion study to evaluate the safety, pharmacokinetics, immunogenicity, and antitumor activity of MEDI3726 in patients with metastatic, castration-resistant prostate cancer who have received prior treatment with abiraterone or enzalutamide. Journal Of Clinical Oncology 2017, 35: tps5088-tps5088. DOI: 10.1200/jco.2017.35.15_suppl.tps5088.Peer-Reviewed Original ResearchProstate-specific membrane antigenCastration-resistant prostate cancerDose-expansion studyAbiraterone acetateProstate cancerDose escalationAntitumor activityPrior treatmentTaxane-based chemotherapyDose-limiting toxicityFurther treatment optionsAnti-PSMA antibodyVivo antitumor activityTarget enrollmentTreatment optionsTherapeutic advancesPreclinical modelsPatientsMembrane antigenSecondary objectiveCancerMCRPCMulticenterTolerabilityExpression levelsPSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,
Bao K, Lee J, Kang H, Park G, Fakhri G, Choi H. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,. Chemical Communications 2017, 53: 1611-1614. PMID: 28085163, PMCID: PMC5728657, DOI: 10.1039/c6cc09781b.Peer-Reviewed Original Research
2012
Cutaneous Myoepithelioma in the Foot
Dix B, Hentges M, Saltrick K, Krishnamurti U. Cutaneous Myoepithelioma in the Foot. Foot & Ankle Specialist 2012, 6: 239-241. PMID: 23263678, DOI: 10.1177/1938640012470713.Peer-Reviewed Original ResearchConceptsCutaneous myoepitheliomasDeep resection marginRight third toeEpithelial membrane antigenSmooth muscle actinResection marginsAnkle literaturePainless massPale cytoplasmOlder womenImmunohistochemical analysisMembrane antigenDermal tumorElliptical excisionThird toeTumor cellsMyoepitheliomaMitotic activityOvoid cellsTumorsFootModerate amountCells
2010
Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation
Ward S, Huang J, Tickoo S, Thung S, Ladanyi M, Klimstra D. Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. Modern Pathology 2010, 23: 1180-1190. PMID: 20495535, DOI: 10.1038/modpathol.2010.105.Peer-Reviewed Original ResearchConceptsFibrolamellar carcinoma casesCases of fibrolamellar carcinomaEpithelial membrane antigenCarcinoma casesHepatocellular carcinoma casesFibrolamellar carcinomaBile duct differentiationHepatocellular carcinomaCytokeratin 7In situ hybridizationNeuroendocrine differentiationMembrane antigenGlypican-3Duct differentiationEvidence of neuroendocrine differentiationCanalicular staining patternPrimary liver neoplasmAlbumin mRNANeuroendocrine markersImmunohistochemical profileHepatocellular differentiationYounger patientsImmunohistochemical markersTumor typesViral hepatitis
2009
Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid.
Galan A, Hui P, McNiff JM. Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid. International Journal Of Clinical And Experimental Pathology 2009, 2: 456-62. PMID: 19294004, PMCID: PMC2655157.Peer-Reviewed Original ResearchHuman herpesvirus 8Presence of HHV8Cases of PVBullous pemphigoidPemphigus vulgarisCases of pemphigusHerpesvirus 8Cases of BPAutoimmune vesiculobullous disordersBasement membrane antigensPolymerase chain reaction techniqueAutoimmune attackChain reaction techniqueHHV8 DNAVesiculobullous diseaseVesiculobullous disordersImmunohistochemical expressionVesicobullous disordersSerologic dataImmunohistochemical localizationMembrane antigenPemphigoidNormal skinPemphigusConfirmatory PCR
2002
Combined Hepatocellular–Cholangiocarcinoma
Tickoo S, Zee S, Obiekwe S, Xiao H, Koea J, Robiou C, Blumgart L, Jarnagin W, Ladanyi M, Klimstra D. Combined Hepatocellular–Cholangiocarcinoma. The American Journal Of Surgical Pathology 2002, 26: 989-997. PMID: 12170085, DOI: 10.1097/00000478-200208000-00003.Peer-Reviewed Original ResearchConceptsCombined hepatocellular-cholangiocarcinomaIn situ hybridizationEpithelial membrane antigenHepatocellular carcinomaHepatocellular markersMembrane antigenElevated serum alpha-fetoprotein levelsSerum alpha-fetoprotein levelAlbumin mRNASerum hepatitis BAggressive clinical courseAlpha-fetoprotein levelsPolyclonal carcinoembryonic antigenAbsence of cirrhosisPrimary liver carcinomaExpression of albumin mRNAHistomorphological spectrumResected casesClinical courseHepatocellular-cholangiocarcinomaImmunohistochemical positivityBiphenotypic differentiationClinical outcomesCytokeratin profileHepatitis B
2000
Evidence for the Neoplastic Transformation of Von-Meyenburg Complexes
Jain D, Sarode V, Abdul–Karim F, Homer R, Robert M. Evidence for the Neoplastic Transformation of Von-Meyenburg Complexes. The American Journal Of Surgical Pathology 2000, 24: 1131-1139. PMID: 10935654, DOI: 10.1097/00000478-200008000-00011.Peer-Reviewed Original ResearchConceptsVon Meyenburg complexesAdenomatous lesionsNeoplastic transformationTumor-like nodulesCongenital hepatic fibrosisDuctal plate malformationPattern of fibrosisBackground of fibrosisCases of cholangiocarcinomaEpithelial membrane antigenYears of ageSmall renal cystsPortal hypertensionDuctular proliferationMicronodular cirrhosisHepatic fibrosisTomographic scanHistologic examinationImmunohistochemical stainingRenal cystsCentral veinMembrane antigenCarcinoembryonic antigenCirrhosisCholangiocarcinomaMyoepithelial Carcinoma of the Salivary Glands
Savera A, Sloman A, Huvos A, Klimstra D. Myoepithelial Carcinoma of the Salivary Glands. The American Journal Of Surgical Pathology 2000, 24: 761-774. PMID: 10843278, DOI: 10.1097/00000478-200006000-00001.Peer-Reviewed Original ResearchConceptsMyoepithelial carcinomaMalignant mixed tumorMixed tumorsImmunohistochemical profileSalivary gland carcinomasEpithelial membrane antigenMuscle-specific actinSalivary gland tumorsHigh-power fieldsDiverse clinical outcomesEvidence of diseaseSmooth muscle actinBenign mixed tumorS-100 proteinGlial fibrillary acidic proteinFibrillary acidic proteinTen tumorsPainless massCytokeratin 7Cytomorphologic featuresGland tumorsClinicopathological featuresMembrane antigenClinical behaviorVascular invasion
1997
Syphilis Serology in Human Immunodeficiency Virus Infection: Evidence for False-Negative Fluorescent Treponemal Testing
Erbelding E, Vlahov D, Nelson K, Rompalo A, Cohn S, Sanchez P, Quinn T, Brathwaite W, Thomas D. Syphilis Serology in Human Immunodeficiency Virus Infection: Evidence for False-Negative Fluorescent Treponemal Testing. The Journal Of Infectious Diseases 1997, 176: 1397-1400. PMID: 9359747, DOI: 10.1086/517330.Peer-Reviewed Original ResearchConceptsFTA-ABS testHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBFP reactionsVirus infectionRapid plasma reagin titerFluorescent treponemal antibody absorption testInjection drug usersAntibody absorption testPresence of antibodiesTreponema pallidum antigensFalse positive reactorsBFP reactorsSyphilis serologySerologic patternTreatment historyDrug usersMembrane antigenTreponemal testingAntigenNegative resultsSyphilisInfectionAntibodiesSerologyMetastatic Adenocarcinoma Involving a Mesothelial/Monocytic Incidental Cardiac Excrescence (Cardiac MICE)
Argani P, Sternberg S, Burt M, Adsay N, Klimstra D. Metastatic Adenocarcinoma Involving a Mesothelial/Monocytic Incidental Cardiac Excrescence (Cardiac MICE). The American Journal Of Surgical Pathology 1997, 21: 970-974. PMID: 9255262, DOI: 10.1097/00000478-199708000-00013.Peer-Reviewed Original ResearchConceptsMesothelial/monocytic incidental cardiac excrescenceMesothelial cellsAdenocarcinoma cellsEpithelial membrane antigenMetastatic adenocarcinoma cellsClusters of histiocytesMetastatic adenocarcinomaMetastatic carcinomaCardiac instrumentationMembrane antigenRight lungIntracellular mucinCarcinoembryonic antigenClinical circumstancesNo historyPericardial spacePleomorphic cellsNon-neoplasticUnique caseAdenocarcinomaHistiocytesMicroscopic findingsPericardial cavityMicroscopic examinationCell clustersMetastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumors
1996
Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy
Wright G, Grob B, Haley C, Grossman K, Newhall K, Petrylak D, Troyer J, Konchuba A, Schellhammer P, Moriarty R. Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy. Urology 1996, 48: 326-334. PMID: 8753752, DOI: 10.1016/s0090-4295(96)00184-7.Peer-Reviewed Original ResearchConceptsProstate-specific membrane antigenAndrogen deprivation therapyExpression of PSMAProstate cancerLNCaP cellsAndrogen deprivationMetastatic specimensMembrane antigenCombination androgen deprivation therapyProstate-specific antigen expressionTissue specimensAntigen-positive tumor cellsHormone-independent prostate cancerPost-treatment specimenAndrogen deprivation treatmentAbsence of androgenPresence of testosteroneExtent of stainingWestern blot analysisAndrogen treatmentPSA expressionMetastatic tissuesPSMA expressionAntigen expressionProstate carcinoma
1995
Report of Eight Cases and Review of the Literature
Hasserjian R, Klimstra D, Rosai J. Report of Eight Cases and Review of the Literature. The American Journal Of Surgical Pathology 1995, 19: 835-841. PMID: 7793482, DOI: 10.1097/00000478-199507000-00012.Peer-Reviewed Original ResearchConceptsClear-cell featuresThymic carcinomaClear-cellCases of thymic carcinomaHigh-grade thymic carcinomasMetastatic clear-cell carcinomaSheet-like growth patternHigh-molecular-weight keratinPrimary thymic carcinomaDead of diseaseClear-cell carcinomaEpithelial membrane antigenAggressive clinical behaviorClear-cell neoplasmsMediastinal seminomaPlacental alkaline phosphataseParathyroid carcinomaPersistent diseaseMembrane antigenClinical behaviorTumor cellsDifferential diagnosisFollow-upCarcinomaNuclear features
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply