2024
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
Ma R, Salinas N, Orr-Gonzalez S, Richardson B, Ouahes T, Torano H, Jenkins B, Dickey T, Neal J, Duan J, Morrison R, Gittis A, Doritchamou J, Zaidi I, Lambert L, Duffy P, Tolia N. Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLOS Pathogens 2024, 20: e1011879. PMID: 38437239, PMCID: PMC10939253, DOI: 10.1371/journal.ppat.1011879.Peer-Reviewed Original ResearchConceptsPlacental malaria vaccinesMalaria vaccineAccumulation of Plasmodium falciparum-infected erythrocytesInfected erythrocytesAccumulation of infected erythrocytesPlasmodium falciparum-infected erythrocytesChondroitin sulfate AMalaria vaccine antigensFalciparum-infected erythrocytesLow birth weightPlacental malariaMaternal anemiaPlacental accumulationVAR2CSABirth weightDesign immunogensPregnancy lossVaccination strategiesVaccine antigensStable immunogensImmunogenicityCocktail strategyPrevent adhesionStructure-guided designAntibodies
2022
The geo-spatial perspective of biological, social and environmental determinants of early pregnancy anaemia in rural Sri Lanka: Need for context-specific approaches on prevention
Amarasinghe G, Agampodi T, Mendis V, Agampodi S. The geo-spatial perspective of biological, social and environmental determinants of early pregnancy anaemia in rural Sri Lanka: Need for context-specific approaches on prevention. Geospatial Health 2022, 17 PMID: 36468596, DOI: 10.4081/gh.2022.1110.Peer-Reviewed Original ResearchConceptsPrevalence of anemiaEarly pregnancyPregnant womenRisk factorsFirst trimester pregnant womenHigher anemia prevalenceAntenatal care programsEnvironmental risk factorsHeterogeneous risk factorsMaternal anemiaPregnancy anemiaPregnancy cohortAnemia prevalenceDietary patternsHigh prevalenceAnemiaCare programRural Sri LankaPrevalenceSocioeconomic disparitiesPregnancyHealth DivisionEthnic distributionSignificant differencesAnuradhapura districtFactors associated with early pregnancy anemia in rural Sri Lanka: Does being ‘under care’ iron out socioeconomic disparities?
Amarasinghe G, Agampodi T, Mendis V, Agampodi S. Factors associated with early pregnancy anemia in rural Sri Lanka: Does being ‘under care’ iron out socioeconomic disparities? PLOS ONE 2022, 17: e0274642. PMID: 36201463, PMCID: PMC9536542, DOI: 10.1371/journal.pone.0274642.Peer-Reviewed Original ResearchConceptsPregnancy anemiaPregnant womenFirst trimester pregnant womenSocioeconomic disparitiesRisk of anemiaOdds of anemiaFull blood countHistory of anemiaContinuum of carePeriod of gestationFamily Health ProgramHierarchical logistic regression modelsSelf-completed questionnaireLogistic regression modelsHealth care coveragePublic health infrastructureMaternal anemiaAntenatal careCohort studyBreast feedingContraceptive injectionMiddle-income countriesAnemia preventionRegression modelsAnemia controlCross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol.
Amarasinghe G, Mendis V, Agampodi T, Agampodi S. Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol. F1000Research 2022, 10: 223. PMID: 35528960, PMCID: PMC9039368, DOI: 10.12688/f1000research.28226.3.Peer-Reviewed Original ResearchConceptsStrong public health systemCross-sectional studyPregnant womenFirst trimesterSignificant global health problemEtiology of anemiaInterviewer-administered questionnaireComplete blood countGlobal health problemPublic health systemAnuradhapura districtDietary questionnaireFetal outcomesMaternal anemiaAntenatal careAnemia controlBlood countSectional studyAnemia casesAnemiaHealth problemsPregnancySimilar etiologyField clinicsEtiology
2021
Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol
Amarasinghe G, Mendis V, Agampodi T, Agampodi S. Cross-sectional study to assess etiology and associated factors for anaemia during first trimester of pregnancy in Anuradhapura District, Sri Lanka: a protocol. F1000Research 2021, 10: 223. DOI: 10.12688/f1000research.28226.2.Peer-Reviewed Original ResearchStrong public health systemCross-sectional studyPregnant womenFirst trimesterSignificant global health problemEtiology of anemiaInterviewer-administered questionnaireComplete blood countGlobal health problemPublic health systemAnuradhapura districtDietary questionnaireFetal outcomesMaternal anemiaAntenatal careAnemia controlBlood countSectional studyAnemia casesAnemiaHealth problemsPregnancySimilar etiologyField clinicsEtiology
2012
An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso
Valea I, Tinto H, Drabo M, Huybregts L, Sorgho H, Ouedraogo J, Guiguemde R, van Geertruyden J, Kolsteren P, D'Alessandro U, the FSP/MISAME study Group. An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. Malaria Journal 2012, 11: 71. PMID: 22433778, PMCID: PMC3338396, DOI: 10.1186/1475-2875-11-71.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAntimalarialsBurkina FasoDrug Administration ScheduleDrug CombinationsFemaleHumansInfant, Low Birth WeightInfant, NewbornMalaria, FalciparumPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPregnancy TrimestersProspective StudiesPyrimethamineRiskSulfadoxineTime FactorsYoung AdultConceptsLow birth weightFirst malaria infectionDoses of SPMalaria infectionBirth weightPerinatal mortalityMaternal anemiaFirst trimesterPregnant womenHigh riskBackgroundA prospective studyIntermittent preventive treatmentAntenatal care visitsHistory of feverIncidence rate ratiosCare visitsThird doseMethodsStudy participantsProspective studySecond trimesterPreventive treatmentHealth centersHealth facilitiesPregnancyInsecticidal nets
2011
Association of maternal anemia with increased wheeze and asthma in children
Triche EW, Lundsberg LS, Wickner PG, Belanger K, Leaderer BP, Bracken MB. Association of maternal anemia with increased wheeze and asthma in children. Annals Of Allergy Asthma & Immunology 2011, 106: 131-139.e1. PMID: 21277514, PMCID: PMC3073499, DOI: 10.1016/j.anai.2010.11.007.Peer-Reviewed Original ResearchConceptsMaternal anemiaEarly-onset transientRespiratory health outcomesChildren of womenOffspring of mothersRespiratory disease developmentChildren of mothersYears of ageEarly childhoodAge 3Delivery hospitalizationsRecurrent wheezeCurrent asthmaAsthma diagnosisChildhood asthmaInfant wheezeMaternal nutritionRespiratory healthWheezeAsthmaAnemiaHealth outcomesPregnancyAnemia diagnosisMicronutrient status
2007
Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania
Fawzi W, Msamanga G, Urassa W, Hertzmark E, Petraro P, Willett W, Spiegelman D. Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania. Obstetrical & Gynecological Survey 2007, 62: 561-563. DOI: 10.1097/01.ogx.0000279296.97522.77.Peer-Reviewed Original ResearchLow birth weightGestational age infantsHIV-negative womenMultivitamin groupBirth weightRelative riskPlacebo groupPreterm birthFetal deathGestational ageMultivitamin supplementsPregnant womenMicronutrient statusDouble-blind trialFolic acidMean birth weightSimilar baseline characteristicsWeeks gestational ageConfidence intervalsPrenatal vitamin supplementationHigher hemoglobin levelsPlacebo recipientsMaternal anemiaPerinatal outcomesBaseline characteristics
1987
Persistent pulmonary hypertension: assessment of perinatal risk factors.
Reece E, Moya F, Yazigi R, Holford T, Duncan C, Ehrenkranz R. Persistent pulmonary hypertension: assessment of perinatal risk factors. Obstetrics And Gynecology 1987, 70: 696-700. PMID: 3658275.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary hypertensionFetal distressRisk factorsOdds ratioThird-trimester bleedingAntenatal risk factorsMothers of neonatesPerinatal risk factorsCesarean section rateLogistic regression analysisAntenatal eventsMaternal feverNonvertex presentationMaternal anemiaVaginal bleedingCesarean sectionControl patientsPulmonary diseaseSection rateRetrospective studyPrimary indicationUnknown etiologyUnivariate analysisStudy group
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply