2024
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
Ma R, Salinas N, Orr-Gonzalez S, Richardson B, Ouahes T, Torano H, Jenkins B, Dickey T, Neal J, Duan J, Morrison R, Gittis A, Doritchamou J, Zaidi I, Lambert L, Duffy P, Tolia N. Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLOS Pathogens 2024, 20: e1011879. PMID: 38437239, PMCID: PMC10939253, DOI: 10.1371/journal.ppat.1011879.Peer-Reviewed Original ResearchConceptsPlacental malaria vaccinesMalaria vaccineAccumulation of Plasmodium falciparum-infected erythrocytesInfected erythrocytesAccumulation of infected erythrocytesPlasmodium falciparum-infected erythrocytesChondroitin sulfate AMalaria vaccine antigensFalciparum-infected erythrocytesLow birth weightPlacental malariaMaternal anemiaPlacental accumulationVAR2CSABirth weightDesign immunogensPregnancy lossVaccination strategiesVaccine antigensStable immunogensImmunogenicityCocktail strategyPrevent adhesionStructure-guided designAntibodies
1999
Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1
Penc S, Pomahac B, Eriksson E, Detmar M, Gallo R. Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1. Journal Of Clinical Investigation 1999, 103: 1329-1335. PMID: 10225976, PMCID: PMC408352, DOI: 10.1172/jci4742.Peer-Reviewed Original ResearchConceptsICAM-1Effect of DSDermatan sulfateCell surface ICAM-1Intercellular adhesion molecule-1Endothelial cellsCultured human dermal microvascular endothelial cellsIntercellular adhesion molecule-1 mRNAIL-1 releaseAdhesion molecule-1Surface ICAM-1Human dermal microvascular endothelial cellsDermal microvascular endothelial cellsMicrovascular endothelial cellsNF-kappaB activationNuclear factor-kappaBTNF-alphaInflammatory phaseMolecule-1Chondroitin sulfate BFactor-kappaBSoluble ICAMChondroitin sulfate ANF-kappaBPhysiologic concentrations
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