2024
Implementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma
Medved M, Witmer H, Dhiman A, Berger Y, Sherman S, Hindi E, Armato S, Reiser I, Oto A, Engelmann R, Kindler H, Oren N, Harmath C, Turaga K. Implementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma. Quantitative Imaging In Medicine And Surgery 2024, 14: 2580589-2582589. PMID: 38545076, PMCID: PMC10963817, DOI: 10.21037/qims-23-13.Peer-Reviewed Original ResearchMalignant peritoneal mesotheliomaMagnetic resonance imagingPeritoneal mesotheliomaPost-contrast imagesDelayed phaseDelayed post-contrast imagesT2-weighted single-shot fast spin-echoHigh-contrast magnetic resonance imagingLow grade tumorsLesion contrast enhancementContrast enhancementSingle-shot fast spin-echoGrade of diseaseDose of contrast agentMagnetic resonance imaging examsMagnetic resonance imaging protocolNovel MRI protocolFeasibility of high-resolutionDefinitive surgeryGrade tumorsPeritoneal malignancyBlinded radiologistsTumor gradeAnalysis of contrast enhancementCross-sectional imaging
2021
Quantitative Computed Tomography Image Analysis to Predict Pancreatic Neuroendocrine Tumor Grade.
Pulvirenti A, Yamashita R, Chakraborty J, Horvat N, Seier K, McIntyre C, Lawrence S, Midya A, Koszalka M, Gonen M, Klimstra D, Reidy D, Allen P, Do R, Simpson A. Quantitative Computed Tomography Image Analysis to Predict Pancreatic Neuroendocrine Tumor Grade. JCO Clinical Cancer Informatics 2021, 5: 679-694. PMID: 34138636, PMCID: PMC8462651, DOI: 10.1200/cci.20.00121.Peer-Reviewed Original ResearchConceptsTumor gradePanNET gradeCT scanComputed tomographyManagement of pancreatic neuroendocrine tumorsPancreatic neuroendocrine tumor gradesRadiographic descriptorsArterial phase CT scansNeuroendocrine tumor gradingTumor grade assessmentPancreatic neuroendocrine tumorsQuantitative image analysisComputed tomography image analysisResected PanNETsGrade tumorsNeuroendocrine tumorsPrimary tumorInstitutional databaseProspective studyTherapeutic managementUnivariate analysisPanNETsTreatment selectionRadiomic featuresTumorSpatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas
Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal Of Neuropathology & Experimental Neurology 2021, 80: 150-159. PMID: 33393633, DOI: 10.1093/jnen/nlaa152.Peer-Reviewed Original ResearchConceptsPD-L1 expressionT cell infiltrationPD-L1PD-L2Human meningiomasTumor-infiltrating immune cell populationsHigh PD-L1 expressionT-cell activation/proliferationActivation/dysfunctionLevels of CD3Immune cell subsetsT-cell phenotypeImmune cell populationsHigh-grade tumorsActivation/proliferationHigher CD3TIL infiltrationCD8 ratioImmunotherapeutic strategiesCell subsetsImmunological statusGrade tumorsImmunological landscapeTissue microarrayMacrophage phenotype
2020
PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker
Horton TM, Sundaram V, Lee CH, Hornbacker K, Van Vleck A, Benjamin KN, Zemek A, Longacre TA, Kunz PL, Annes JP. PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker. Scientific Reports 2020, 10: 10943. PMID: 32616904, PMCID: PMC7331689, DOI: 10.1038/s41598-020-68071-6.Peer-Reviewed Original ResearchConceptsPrimary neuroendocrine neoplasmsNeuroendocrine neoplasmsPAM immunoreactivityPAM stainingStage-independent predictorUnpredictable clinical behaviorRisk of deathIndividual patient prognosisRare epithelial tumorsHigh-grade tumorsPotential prognostic biomarkerMedian timeSmall bowelAvailable biomarkersTumor sizeDisease stageClinical associationsGrade tumorsClinical behaviorPatient prognosisPrognostic biomarkerEpithelial tumorsTherapy selectionSurvival implicationsPatientsNovel artificial intelligence system increases the detection of prostate cancer in whole slide images of core needle biopsies
Raciti P, Sue J, Ceballos R, Godrich R, Kunz J, Kapur S, Reuter V, Grady L, Kanan C, Klimstra D, Fuchs T. Novel artificial intelligence system increases the detection of prostate cancer in whole slide images of core needle biopsies. Modern Pathology 2020, 33: 2058-2066. PMID: 32393768, PMCID: PMC9235852, DOI: 10.1038/s41379-020-0551-y.Peer-Reviewed Original ResearchConceptsWhole slide imagesProstate needle core biopsiesArtificial intelligence systemsNeedle core biopsyIntelligent systemsCore biopsyProstate cancerState-of-the-artDetection of prostate cancerMachine learning algorithmsCore needle biopsyHigh test accuracyLow grade tumorsWell-differentiated cancersStained with hematoxylin and eosinAverage sensitivityLearning algorithmsHematoxylin and eosinGenitourinary pathologistsGrade tumorsNeedle biopsyDetection systemPathological diagnosisStatistically significant changesAncillary studies
2019
Outcomes of upper tract urothelial cancer managed non-surgically.
Syed JS, Nguyen KA, Suarez-Sariemento A, Leung C, Casilla-Lennon M, Raman JD, Shuch B. Outcomes of upper tract urothelial cancer managed non-surgically. Canadian Journal Of Urology 2019, 26: 9699-9707. PMID: 31012833.Peer-Reviewed Original ResearchConceptsUpper tract urothelial cancerCharlson-Deyo scoreMedian overall survivalOverall survivalTumor gradeCox proportional hazards regression modelProportional hazards regression modelsNational Cancer DatabaseKaplan-Meier methodHazards regression modelsHigh-grade tumorsGovernment health insuranceDefinitive surgeryDefinitive therapyGreater comorbidityOlder patientsMedian agePatient demographicsWorse survivalUrothelial cancerGrade tumorsAlternative therapiesCancer DatabaseOS differenceRadiation therapyThe nonsurgical management of upper tract urothelial carcinoma: A role for active surveillance?
Syed J, Nguyen K, Javier-Desloges J, Leapman M, Raman J, Shuch B. The nonsurgical management of upper tract urothelial carcinoma: A role for active surveillance? Journal Of Clinical Oncology 2019, 37: 485-485. DOI: 10.1200/jco.2019.37.7_suppl.485.Peer-Reviewed Original ResearchUpper tract urothelial cancerMedian overall survivalOverall survivalTumor gradeCox proportional hazards regression modelProportional hazards regression modelsNational Cancer DatabaseKaplan-Meier methodHazards regression modelsHigh-grade tumorsGovernment health insuranceDefinitive surgeryDefinitive therapyOlder patientsPatient demographicsMedian ageWorse survivalUrothelial cancerGrade tumorsAlternative therapiesCancer DatabaseOS differenceRadiation therapyPatientsSurvival analysis
2016
Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer
Fu Y, Biglia N, Wang Z, Shen Y, Risch HA, Lu L, Canuto EM, Jia W, Katsaros D, Yu H. Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer. Gynecologic Oncology 2016, 143: 642-649. PMID: 27667152, PMCID: PMC5507336, DOI: 10.1016/j.ygyno.2016.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinoma, Clear CellAdultAgedAged, 80 and overCarcinoma, EndometrioidCarcinoma, Ovarian EpithelialHumansMiddle AgedNeoplasm GradingNeoplasm StagingNeoplasms, Cystic, Mucinous, and SerousNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisProportional Hazards ModelsReverse Transcriptase Polymerase Chain ReactionRNA, Long NoncodingYoung AdultConceptsEpithelial ovarian cancerOvarian cancerStage diseasePatient survivalGrade tumorsASAP1-IT1Survival associationsLong non-coding RNAsCox proportional hazards regression modelPrimary epithelial ovarian cancerProportional hazards regression modelsTumor samplesFresh frozen tumor samplesHigh expressionEarly-stage diseaseFavorable overall survivalLate-stage diseaseHazards regression modelsLow-grade tumorsHigh-grade tumorsOvarian cancer progressionNon-coding RNAsImportant biological actionsOverall survivalPoor prognosis
2015
Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Cancer: Results From the National Cancer Data Base
Killelea BK, Yang VQ, Wang SY, Hayse B, Mougalian S, Horowitz NR, Chagpar AB, Pusztai L, Lannin DR. Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Cancer: Results From the National Cancer Data Base. Journal Of Clinical Oncology 2015, 33: 4267-4276. PMID: 26598753, DOI: 10.1200/jco.2015.63.7801.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsAsianBiomarkers, TumorBlack or African AmericanBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularChemotherapy, AdjuvantComorbidityDatabases, FactualFemaleHispanic or LatinoHumansInsurance CoverageInsurance, HealthMiddle AgedNeoadjuvant TherapyNeoplasm GradingNeoplasm StagingReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneTreatment OutcomeTriple Negative Breast NeoplasmsUnited StatesWhite PeopleConceptsPathologic complete responseNational Cancer Data BaseNeoadjuvant chemotherapyBreast cancerEstrogen receptorWhite womenPositive tumorsAsian womenHuman epidermal growth factor receptor 2HER2-positive breast cancerEpidermal growth factor receptor 2Timing of chemotherapyClinical T stageGrowth factor receptor 2Triple-negative tumorsPatient's zip codeHigh-grade tumorsRacial differencesZip codesFactor receptor 2Chemotherapy useComorbidity indexComplete responseT stageGrade tumors
2010
Let-7a regulation of insulin-like growth factors in breast cancer
Lu L, Katsaros D, Zhu Y, Hoffman A, Luca S, Marion CE, Mu L, Risch H, Yu H. Let-7a regulation of insulin-like growth factors in breast cancer. Breast Cancer Research And Treatment 2010, 126: 687-694. PMID: 20848182, DOI: 10.1007/s10549-010-1168-5.Peer-Reviewed Original ResearchConceptsIGF expressionBreast cancerOvarian cancerInsulin-like growth factorDisease-free survivalCancer cellsAction of IGFBreast cancer patientsExpression of IGFHigh-grade tumorsIGF-II expressionPR-negative cancerLet-7aQuantitative methylation-specific PCRBreast cancer samplesOverall survivalFavorable prognosisPatient survivalCancer patientsGrade tumorsIGF mRNAsMethylation-specific PCRDisease featuresCancerCancer samples
2007
Pancreatic neuroendocrine tumors: Can the WHO staging system be simplified
Ferrone C, Tang L, Tomplinson J, Klimstra D, Coit D, Brennan M, Allen P. Pancreatic neuroendocrine tumors: Can the WHO staging system be simplified. Journal Of Clinical Oncology 2007, 25: 15038-15038. DOI: 10.1200/jco.2007.25.18_suppl.15038.Peer-Reviewed Original ResearchPancreatic endocrine neoplasmsDisease-specific survivalAssociated with survivalMetastatic diseaseTumor stageWorld Health OrganizationPrognostic value of stageEvidence of metastatic diseasePresence of nodal metastasesInfluence of tumor stageLow grade diseaseDistant metastatic diseaseIntermediate grade tumorsLow-grade tumorsEarly stage tumorsWorld Health Organization staging systemAccurate prognostic informationGrade tumorsNodal metastasisGrade diseasePrimary tumorDisease recurrencePositive nodesPrognostic factorsStage tumors
1998
Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study
Platz E, Giovannucci E, Rimm E, Curhan G, Spiegelman D, Colditz G, Willett W. Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study. American Journal Of Epidemiology 1998, 147: 1140-1144. PMID: 9645792, DOI: 10.1093/oxfordjournals.aje.a009412.Peer-Reviewed Original ResearchConceptsHealth Professionals FollowBirth weightProstate cancerProfessionals FollowProstate cancer incidenceMultivariate logistic modelModest positive associationGrade tumorsProstatic cancerCancer incidenceRelative riskRetrospective analysisOverall associationCancerPositive associationFollowAssociationLogistic modelWeightTumorsIncidenceExpression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors
1992
The role of fine‐needle aspiration biopsy of the prostate in staging adenocarcinoma
Honig S, Stilmant M, Klavans M, Freedlund M, Siroky M. The role of fine‐needle aspiration biopsy of the prostate in staging adenocarcinoma. Cancer 1992, 69: 2978-2982. PMID: 1591691, DOI: 10.1002/1097-0142(19920615)69:12<2978::aid-cncr2820691219>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsMalignant cytologic findingsFine-needle aspiration biopsyStage A1 diseaseCytologic findingsProstate cancerStage A1A2 diseaseTURP specimenAspiration biopsyIncidental prostate cancerModerate-grade tumorsStage A2 diseaseTherapy of patientsHigh-grade tumorsClinical suspicionOutlet obstructionConsecutive patientsTransurethral resectionBetter prognosisHistologic evidenceGrade tumorsHistologic findingsRadical prostatectomyIncidental findingStage A2
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