2022
Sex Differences in Peripheral Artery Disease
Pabon M, Cheng S, Altin S, Sethi S, Nelson M, Moreau K, Hamburg N, Hess C. Sex Differences in Peripheral Artery Disease. Circulation Research 2022, 130: 496-511. PMID: 35175843, PMCID: PMC8919803, DOI: 10.1161/circresaha.121.320702.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseManagement of PADSuch sex-based differencesNontraditional risk factorsSex differencesLack of diagnosisSex-based differencesImportant sex differencesIschemic cardiovascularPAD prevalenceVascular stressorSubstantial morbidityClinical presentationClinical manifestationsRisk factorsPrevalent conditionLimb eventsOverall populationVascular substratesDiseaseSex variationWomenCurrent knowledgeManifestationsSex differences in developmental patterns of neocortical astroglia: A mouse translatome database
Rurak GM, Simard S, Freitas-Andrade M, Lacoste B, Charih F, Van Geel A, Stead J, Woodside B, Green JR, Coppola G, Salmaso N. Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database. Cell Reports 2022, 38: 110310. PMID: 35108542, DOI: 10.1016/j.celrep.2022.110310.Peer-Reviewed Original ResearchConceptsGene expression patternsRibosome affinity purificationDevelopmental time pointsAstroglial phenotypeMaintenance of neuronsRNA sequencingAffinity purificationExpression patternsTelencephalic developmentAstroglial cellsSteroid hormone receptorsSex differencesKey playersNeuronal networksHormone receptorsDevelopmental patternsImportant sex differencesPhenotypeDevelopmental sex differencesWindow of vulnerabilityFemale miceHormonal manipulationPostnatal developmentAstrogliaTranslatome
2019
Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activityAltered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.Peer-Reviewed Original ResearchConceptsAltered connectivityDepressed patientsExcitatory glutamate neuronsMajor neuronal typesRapid-acting agentsAtrophy of neuronsTreatment of depressionLimbic brain regionsChronic stress exposureStress-related disordersBrain imaging studiesImportant sex differencesNeurotransmitter deficitsGABA interneuronsImmunologic mechanismsGlutamate neuronsCurrent antidepressantsExcitotoxic effectsNeurochemical deficitsGlutamate dysfunctionPathophysiological mechanismsGABA systemInflammatory cytokinesAdrenal glucocorticoidsHippocampal regionEndocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma
Nia A, Bender R, Harpaz-Rotem I. Endocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma. Chronic Stress 2019, 3: 2470547019864096. PMID: 31660473, PMCID: PMC6816276, DOI: 10.1177/2470547019864096.Peer-Reviewed Original ResearchEndocannabinoid system alterationsEndocannabinoid systemSystem alterationsEndocannabinoid ligandsProlonged stressPosttraumatic stress disorderImportant sex differencesClinical studiesPsychiatric symptomsCannabinoid receptorsHuman studiesChronic stressStress disorderTraumaDecreased levelsDevelopmental ageSex differencesCurrent literatureReceptorsAlterationsAccumulative effectReviewSymptomsLevels
2016
Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters
Smith KZ, Smith PH, Cercone SA, McKee SA, Homish GG. Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters. Addictive Behaviors 2016, 58: 167-174. PMID: 26946448, PMCID: PMC4808454, DOI: 10.1016/j.addbeh.2016.02.019.Peer-Reviewed Original ResearchConceptsOpioid use disorder diagnosisNon-medical opioid usePosttraumatic stress disorderHigher oddsSymptom clustersPTSD diagnosisDisorder diagnosisOpioid useAvoidance symptom clustersAverage monthly frequencyNon-institutionalized adultsNational Epidemiologic SurveyIndividual symptom clustersHigh rateSex differencesSpecific symptom clustersImportant sex differencesPTSD symptom clustersReactivity clustersAdjusted modelGeneral U.S.Epidemiologic SurveyRelated conditionsStress disorderDiagnosis
2015
Childhood Adversity Interacts With Adult Stressful Events to Predict Reduced Likelihood of Smoking Cessation Among Women but Not Men
Smith PH, Oberleitner LM, Smith KM, McKee SA. Childhood Adversity Interacts With Adult Stressful Events to Predict Reduced Likelihood of Smoking Cessation Among Women but Not Men. Clinical Psychological Science 2015, 4: 183-193. PMID: 27026829, PMCID: PMC4808300, DOI: 10.1177/2167702615584589.Peer-Reviewed Original ResearchSmoking cessationStressful life eventsChildhood adversityNon-daily smokersNational Epidemiologic SurveySex differencesLife eventsImportant sex differencesStress sensitization modelPsychiatric outcomesEpidemiologic SurveyClinical targetsRelated conditionsThree-way interactionCessationLower likelihoodEarly stressWomenStressful eventsWave 1MenCurrent studyFurther explorationAdversitySmokers
2011
Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women
Reeves M, Wilkins T, Lisabeth L, Schwamm L. Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women. Women's Health 2011, 7: 383-390. PMID: 21612358, DOI: 10.2217/whe.11.31.Peer-Reviewed Original ResearchConceptsThrombolysis treatmentIschemic strokeObservational studyTPA treatmentSex differencesAcute ischemic strokeComparable control groupImportant sex differencesIssues of efficacyThrombolysis trialsAcute strokeStroke communityTreatment efficacyControl groupGreater efficacyTrial dataStrokeWomenEfficacyLow utilizationGood evidenceMore studiesTreatmentMenWide variability
2006
Antisocial personality and stress-induced brain activation in cocaine-dependent patients
Li CS, Kosten TR, Sinha R. Antisocial personality and stress-induced brain activation in cocaine-dependent patients. Neuroreport 2006, 17: 243-247. PMID: 16462591, DOI: 10.1097/01.wnr.0000199471.06487.a2.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsDistress processingBrain activationStress imageryAntisocial personalitySocialization scoresFunctional magnetic resonance imaging studyAbstinent cocaine-dependent individualsRegional brain activationStress-induced brain activationFemale participantsMedial prefrontal cortexMagnetic resonance imaging studyResonance imaging studyNeural correlatesLower socialization scoresCocaine-dependent patientsCorticolimbic brain regionsPrefrontal cortexImportant sex differencesBrain regionsPersonalityInterest analysisSignificant activationEffect size
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge
1992
Women and AIDS in the United States: Epidemiology, Natural History, and Mediating Mechanisms
Ickovics J, Rodin J. Women and AIDS in the United States: Epidemiology, Natural History, and Mediating Mechanisms. Health Psychology 1992, 11: 1-16. PMID: 1559529, DOI: 10.1037/0278-6133.11.1.1.Peer-Reviewed Original ResearchConceptsNatural historyHuman immunodeficiency virusProportion of womenImportant sex differencesImmunodeficiency syndromeImmunodeficiency virusViral exposureDisease outcomeEpidemiologic reviewDisease processPsychosocial factorsU.S. womenAIDSWomenStudy of menHIVPsychosocial mechanismsSex differencesDiseaseSocial supportPreventionTreatmentMale counterpartsSyndromeEpidemiology
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