2025
Impact of young adult life transitions on adult mental health problems: a propensity score analysis
Copeland W, Prytherch S, Rothenberg W, Godwin J, Gaydosh L, Gutin I, Tong G, Shanahan L. Impact of young adult life transitions on adult mental health problems: a propensity score analysis. Psychological Medicine 2025, 55: e152. PMID: 40384216, PMCID: PMC12094619, DOI: 10.1017/s0033291725001072.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAntisocial Personality DisorderFemaleHumansLife Change EventsMaleMental DisordersPropensity ScoreProspective StudiesSubstance-Related DisordersYoung AdultConceptsMental health problemsMental health symptomsAdult life transitionsHealth symptomsYoung adults transitionAntisocial personality disorder symptomsLife transitionsAntisocial personality symptomsPersonality disorder symptomsGreat Smoky Mountains StudyAdult mental health problemsChildhood mental health problemsEarly life adversityChildhood mental health symptomsDisorder symptomsLife adversityPersonality symptomsPsychiatric symptomsEmotional symptomsAdult transitionSubstance useHealth problemsMountains StudyYoung adulthoodSymptomsMentalisation-based treatment for antisocial personality disorder in males convicted of an offence on community probation in England and Wales (Mentalization for Offending Adult Males, MOAM): a multicentre, assessor-blinded, randomised controlled trial
Fonagy P, Simes E, Yirmiya K, Wason J, Barrett B, Frater A, Cameron A, Butler S, Hoare Z, McMurran M, Moran P, Crawford M, Pilling S, Allison E, Yakeley J, Bateman A. Mentalisation-based treatment for antisocial personality disorder in males convicted of an offence on community probation in England and Wales (Mentalization for Offending Adult Males, MOAM): a multicentre, assessor-blinded, randomised controlled trial. The Lancet Psychiatry 2025, 12: 208-219. PMID: 39978982, DOI: 10.1016/s2215-0366(24)00445-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionAntisocial Personality DisorderCost-Benefit AnalysisCriminalsEnglandHumansMaleMiddle AgedTreatment OutcomeWalesYoung AdultConceptsOvert Aggression Scale-ModifiedAntisocial personality disorderMentalisation-based treatmentPersonality disorderDSM-5 criteriaReducing aggressive behaviorService supervisionGroup therapy sessionsEffects of thoughtsCriminal justice systemForensic populationsTreatment gainsDSM-5Psychological treatmentPathway servicesTherapy sessionsAggressive behaviorIndividual sessionsJustice systemCommunity probationFollow-up timepointsUsual groupProbationFindings’ generalisability,Trial proceduresThe Factor Structure and Validity of the Psychopathy Checklist‐Short Version When Used With Autistic Psychiatric Inpatients
Maguire K, Barnoux M, Collins J, Melvin C, Inkson I, Alexander R, Devapriam J, Duggan C, Shepstone L, Staufenburg E, Thompson P, Turner D, Viding E, Langdon P. The Factor Structure and Validity of the Psychopathy Checklist‐Short Version When Used With Autistic Psychiatric Inpatients. Autism Research 2025, 18: 614-631. PMID: 39963077, PMCID: PMC11928917, DOI: 10.1002/aur.70004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntisocial Personality DisorderAutistic DisorderChecklistEnglandFactor Analysis, StatisticalFemaleHospitals, PsychiatricHumansInpatientsIntellectual DisabilityMaleMiddle AgedPersonality TestsPrisonersProspective StudiesPsychometricsRegression AnalysisReproducibility of ResultsROC CurveWalesYoung AdultConceptsMental Health ActPCL:SVPersonality disorder diagnosisForensic historyHealth ActIntellectual disabilityAutistic adultsDisorder diagnosisHistory of violent offendingPCL:SV scoresMeasures of psychopathyInpatient psychiatric hospitalizationPart IIInpatient psychiatric carePCL-SVCriminal offendingHCR-20Violent offendersSV scoresPsychiatric inpatientsFactor structurePsychiatric hospitalPsychopathyPsychiatric careLesser security
2024
Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample.
Carlisi C, Fielder J, Knodt A, Romer A, Hariri A, Viding E. Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample. Journal Of Personality Disorders 2024, 38: 535-558. PMID: 39705101, DOI: 10.1521/pedi.2024.38.6.535.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntisocial Personality DisorderFemaleHumansImpulsive BehaviorLife StyleMaleMental DisordersPsychopathologyStudentsYoung AdultConceptsPsychopathic traitsAntisocial facet of psychopathyBehavioral features of psychopathyFacets of psychopathyFeatures of psychopathySample of young adultsYoung adult sampleMental health problemsU.S. undergraduate studentsAntisocial facetPersonality disorderLifestyle facetGeneral psychopathologyAffective facetsAntisocial behaviorExternalizing behaviorsAdult samplesPsychopathologyPsychopathyInternalizing behaviorsBehavioral featuresUndergraduate studentsYoung adultsLifestyle traitsDifferential mappingAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociation
2023
Promoting Empathy and Affiliation in Relationships (PEAR) study: protocol for a longitudinal study investigating the development of early childhood callous-unemotional traits
Wagner N, Perkins E, Rodriguez Y, Ordway C, Flum M, Hernandez-Pena L, Perelstein P, Sem K, Paz Y, Plate R, Popoola A, Lynch S, Astone K, Goldstein E, Njoroge W, Raine A, Pincus D, Pérez-Edgar K, Waller R. Promoting Empathy and Affiliation in Relationships (PEAR) study: protocol for a longitudinal study investigating the development of early childhood callous-unemotional traits. BMJ Open 2023, 13: e072742. PMID: 37802613, PMCID: PMC10565261, DOI: 10.1136/bmjopen-2023-072742.Peer-Reviewed Original ResearchAntisocial Personality DisorderChild, PreschoolConduct DisorderEmotionsEmpathyFemaleHumansLongitudinal StudiesMaleParentingGenome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders
Li W, Zhou H, Thygesen J, Heydtmann M, Smith I, Degenhardt F, Nöthen M, Morgan M, Kranzler H, Gelernter J, Bass N, McQuillin A. Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders. Psychiatric Genetics 2023, 33: 233-242. PMID: 37756443, PMCID: PMC10635348, DOI: 10.1097/ypg.0000000000000352.Peer-Reviewed Original ResearchMeSH KeywordsAntisocial Personality DisorderAnxiety DisordersGenome-Wide Association StudyHumansRisk FactorsConceptsAntisocial personality disorderAttention deficit hyperactivity disorderSubstance use disordersPosttraumatic stress disorderGenome-wide association studiesDeficit hyperactivity disorderDisorder diagnostic criteriaRisk factorsFrontal cortexDiagnostic criteriaUse disordersRisk score analysisAnterior cingulateAlcohol-dependent participantsPsychiatric conditionsSignificant associationBrain regionsPersonality disorder diagnostic criteriaStress disorderAnxiety disordersASPD criteriaHyperactivity disorderPolygenic risk score analysisPersonality disorderScore analysis
2022
Construct validity of DSM-5 cannabis use disorder diagnosis and severity levels in adults with problematic substance use
Fink D, Shmulewitz D, Mannes Z, Stohl M, Livne O, Wall M, Hasin D. Construct validity of DSM-5 cannabis use disorder diagnosis and severity levels in adults with problematic substance use. Journal Of Psychiatric Research 2022, 155: 387-394. PMID: 36182768, PMCID: PMC9590423, DOI: 10.1016/j.jpsychires.2022.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderCravingDiagnostic and Statistical Manual of Mental DisordersHallucinogensHumansMarijuana AbuseSubstance-Related DisordersConceptsDSM-5 cannabis use disorderSevere cannabis use disorderCannabis use disorderDSM-5Cannabis useAssociated with other psychiatric disordersSubstance useCannabis use disorder diagnosesCannabis use variablesPast-year cannabis useDSM-5 definitionSeverity levelsAddiction treatment programsProblematic substance useCannabis cravingCraving criterionDSM-IVSocial impairmentPsychiatric disordersDisorder diagnosisUse disorderAssociated with validityConcurrent validityTreatment programsSocial functioning
2021
Decision-making ability, psychopathology, and brain connectivity
Moutoussis M, Garzón B, Neufeld S, Bach D, Rigoli F, Goodyer I, Bullmore E, Consortium N, Fonagy P, Jones P, Hauser T, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R, Guitart-Masip M, Dolan R. Decision-making ability, psychopathology, and brain connectivity. Neuron 2021, 109: 2025-2040.e7. PMID: 34019810, PMCID: PMC8221811, DOI: 10.1016/j.neuron.2021.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAntisocial Personality DisorderAnxietyBrainCognitionDecision MakingDepressionDepressive Disorder, MajorFactor Analysis, StatisticalFemaleFunctional NeuroimagingHumansIntelligence TestsMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPsychosocial FunctioningSelf ConceptSocial InteractionYoung AdultConceptsDecision-making abilityFunctional connectivityResting-state functional connectivityGeneral social functioningDecision-making measuresPoor social functionCognitive constructsCognitive processesBrain signaturesSocial functioningThought patternsBrain connectivityMental healthMultiple domainsSocial functionIQBrain dataCommon factorsYoung peopleConstructsIndividuals 18Neural networkConnectivityAbilityPsychopathology
2020
Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents
Brewer A, Saunders R, Fearon P, Fonagy P, Cottrell D, Kraam A, Pilling S, Simes E, Anokhina A, Butler S. Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents. European Child & Adolescent Psychiatry 2020, 31: 177-187. PMID: 33330952, PMCID: PMC8816781, DOI: 10.1007/s00787-020-01695-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAntisocial Personality DisorderCognitionFemaleHumansMalePeer GroupPeer InfluenceConceptsPeer selection effectsDelinquent peer associationPeer conflictAntisocial behaviorPeer influenceSerious antisocial behaviorPeer associationAntisocial cognitionSelf-reported antisocial behaviorPeer influence effectsAntisocial adolescentsBritish adolescentsInfluence effectsPredictive relationshipAdolescentsCognitionCriminological literatureBeliefsAttitudesSelection effectsTotal effectCausal mechanismsConflictBehaviorFindings
2019
Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
Deak J, Gizer I, Otto J, Bizon C, Wilhelmsen K. Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. Journal Of Studies On Alcohol And Drugs 2019, 80: 585-593. PMID: 31790348, PMCID: PMC6900988, DOI: 10.15288/jsad.2019.80.585.Peer-Reviewed Original ResearchConceptsVariant associationsCommon variant associationsRare variant association testsRare variant signalsGene-based analysisRare variant associationsMolecular genetic studiesSingle variant analysisIntergenic regionRare variationAlcohol use disorderTop associationsSequencing dataVariant contributionsGenetic studiesAlcoholism (COGA) sampleGenetic sequencing dataReceptor geneUse disordersVariant signalsGene variationTypes of variationConfer riskStrong associationSignificant associationTowards understanding atypical social affiliation in psychopathy
Viding E, McCrory E. Towards understanding atypical social affiliation in psychopathy. The Lancet Psychiatry 2019, 6: 437-444. PMID: 31006435, DOI: 10.1016/s2215-0366(19)30049-5.Peer-Reviewed Original ResearchConceptsSocial affiliationNeural systemsNeurocognitive vulnerabilityNegative emotionsAuthentic social relationshipsProsocial behaviorProsocial interactionsNeurocognitive findingsPsychopathySocial relationshipsDistressResearch directionsIndividualsAffiliationEmotionsGuiltEnjoymentMotivationAttachmentFindingsVulnerabilityRelationshipResearch effortsBehavior
2018
Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update
Bulbena-Cabre A, Bassir Nia A, Perez-Rodriguez MM. Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update. Current Psychiatry Reports 2018, 20: 74. PMID: 30094700, DOI: 10.1007/s11920-018-0934-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntisocial Personality DisorderBorderline Personality DisorderGene-Environment InteractionHumansPersonality DisordersConceptsBorderline personality disorderGene-environment interactionsPersonality disorderAvoidant personality disorderNew therapeutic dimensionPurpose of ReviewWeEpigenetic changesPharmacological treatmentTherapeutic approachesMost personality disordersChildhood sexual abuseDisordersRecent FindingsResearchSusceptibility genesCurrent knowledgeFuture studiesTherapeutic dimensionPsychopathic traits are differentially associated with efficiency of neural communication
Tillem S, van Dongen J, Brazil IA, Baskin‐Sommers A. Psychopathic traits are differentially associated with efficiency of neural communication. Psychophysiology 2018, 55: e13194. PMID: 29700834, DOI: 10.1111/psyp.13194.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntisocial Personality DisorderBrain WavesCerebral CortexElectroencephalographyFemaleFunctional NeuroimagingHumansMaleMiddle AgedNerve NetYoung AdultConceptsConnectivity matrixGraph theory approachGraph theoryImpulsive-antisocial traitsPsychopathic traitsNeural communicationGraph analysisElevated psychopathic traitsSelf-reported psychopathyTheory approachFrequency bandInterpersonal-affective traitsResting-state EEGNeural networkNeural efficiencyConnectivity methodsGamma frequency bandNeural regionsPrimary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms
Sethi A, McCrory E, Puetz V, Hoffmann F, Knodt A, Radtke S, Brigidi B, Hariri A, Viding E. Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 1013-1021. PMID: 29752216, PMCID: PMC6185817, DOI: 10.1016/j.bpsc.2018.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainEmotionsEmpathyFearFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePhotic StimulationVolunteersYoung AdultConceptsAnterior cingulate cortexNeurocognitive mechanismsPsychopathic traitsPrimary psychopathySecondary psychopathyCingulate cortexEmotional face processing taskComparison groupDifferent neurocognitive mechanismsDistinct neural correlatesFace processing taskFunctional magnetic resonance imagingInferior parietal lobeVolunteer sampleAnger processingNeurocognitive correlatesInsula activityNeural correlatesNeural responsesAnxiety measuresNeural activationSecondary presentationLower anxietyPsychopathy groupHigh anxietyEmotional Intelligence in Incarcerated Female Offenders With Psychopathic Traits.
Edwards BG, Ermer E, Salovey P, Kiehl KA. Emotional Intelligence in Incarcerated Female Offenders With Psychopathic Traits. Journal Of Personality Disorders 2018, 33: 370-393. PMID: 29505384, DOI: 10.1521/pedi_2018_32_349.Peer-Reviewed Original ResearchConceptsEmotional intelligencePsychopathic traitsFemale offendersAbility-based emotional intelligenceGender differencesManagement of emotionsIncarcerated Female OffendersAffective psychopathic traitsEmotional abilitiesEmotional functioningEmotional impairmentsSocial functioningCore featuresEmotionsMale offendersSmall relationshipOffendersPsychopathyOffender dataFunctioningIntelligenceTraitsEmpathyDifficultiesRelationship
2017
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
Tielbeek JJ, Johansson A, Polderman TJC, Rautiainen MR, Jansen P, Taylor M, Tong X, Lu Q, Burt AS, Tiemeier H, Viding E, Plomin R, Martin NG, Heath AC, Madden PAF, Montgomery G, Beaver KM, Waldman I, Gelernter J, Kranzler HR, Farrer LA, Perry JRB, Munafò M, LoParo D, Paunio T, Tiihonen J, Mous SE, Pappa I, de Leeuw C, Watanabe K, Hammerschlag AR, Salvatore JE, Aliev F, Bigdeli TB, Dick D, Faraone SV, Popma A, Medland SE, Posthuma D. Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior. JAMA Psychiatry 2017, 74: 1242-1250. PMID: 28979981, PMCID: PMC6309228, DOI: 10.1001/jamapsychiatry.2017.3069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntisocial Personality DisorderChildConduct DisorderEnvironmentFemaleFinlandGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritanceSex FactorsConceptsNovel genetic risk variantsSingle nucleotide polymorphism-based heritabilityGenome-wide association studiesGenome-wide association dataCausal genetic variantsGenome-wide genotypesPolygenic risk score analysisGenetic architectureGenetic risk variantsInverse genetic correlationPromising lociAssociation studiesBiological pathwaysPleiotropic associationsQuantitative phenotypesGenetic correlationsPsychiatric traitsAssociation dataGenetic effectsRisk variantsRisk score analysisGenetic variantsGenetic originDiscovery sampleTraitsUnderstanding the development of psychopathy: progress and challenges
Viding E, McCrory E. Understanding the development of psychopathy: progress and challenges. Psychological Medicine 2017, 48: 566-577. PMID: 29032773, DOI: 10.1017/s0033291717002847.Peer-Reviewed Original ResearchConceptsCU traitsCallous-unemotional traitsDevelopment of psychopathyExtant research findingsGroup of childrenInformative studiesDistress cuesResearch findingsIndividual differencesBrain activationProtective environmental factorsPsychopathyPrevention programsChildrenClinical implicationsStrong heritabilityClinical outcomesElevated riskEmpathyCuesTraitsGuiltHeritable riskFindingsAdulthoodReduced Laughter Contagion in Boys at Risk for Psychopathy
O’Nions E, Lima C, Scott S, Roberts R, McCrory E, Viding E. Reduced Laughter Contagion in Boys at Risk for Psychopathy. Current Biology 2017, 27: 3049-3055.e4. PMID: 28966092, PMCID: PMC5640510, DOI: 10.1016/j.cub.2017.08.062.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntisocial Personality DisorderCerebral CortexChildHumansLaughterMaleSocial BehaviorConceptsAntisocial behaviorNeural responsesAnterior insula responseAuditory-motor processingImportance of affiliationSupplementary motor areaAtypical processingNeurocognitive processesAction tendenciesInsula responseEmotional experienceHuman laughterAnterior insulaSocial reciprocityMotor readinessPsychopathic traitsAffiliative bondsSocial affiliationPremotor regionsEmotional resonanceSocial behaviorMotor areaSubjective feelingsBehavioral profileSocial animals
2016
Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits
Seara-Cardoso A, Sebastian C, McCrory E, Foulkes L, Buon M, Roiser J, Viding E. Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits. Scientific Reports 2016, 6: 36273. PMID: 27808160, PMCID: PMC5093734, DOI: 10.1038/srep36273.Peer-Reviewed Original ResearchConceptsAnticipation of guiltEveryday moral transgressionsPsychopathic traitsAnterior insulaMoral transgressionsInterpersonal psychopathic traitsPattern of findingsNeurocognitive mechanismsMotivational processingMoral emotionsNeural responsesAntisocial behaviorMoral behaviorSocial normsGuiltInsulaPersonality disorderSecond sampleAnticipationHigh levelsSignificant interactionWrongnessTransgressionEmotionsTraits
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