2015
Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress
Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS. Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLOS Biology 2015, 13: e1002282. PMID: 26506154, PMCID: PMC4623974, DOI: 10.1371/journal.pbio.1002282.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBehavior, AnimalCohort StudiesDendritic SpinesDepressive Disorder, MajorEnzyme RepressionFemaleGene Transfer TechniquesHippocampusHumansImmediate-Early ProteinsMaleMiddle AgedNerve Tissue ProteinsNeuronsPrefrontal CortexProtein Serine-Threonine KinasesRats, Sprague-DawleySignal TransductionStress Disorders, Post-TraumaticSynaptic TransmissionTissue BanksConceptsMajor depressive disorderPost-traumatic stress disorderPrefrontal cortexAbnormal dendritic spine morphologyCorticolimbic brain regionsAnhedonic-like behaviorInhibition of SGK1Dendritic spine morphologyKinase 1 expressionAmygdala of individualsTraumatic stressPostmortem prefrontal cortexSynaptic dysfunctionDepressive disorderBehavioral deficitsRodent modelsPTSD subjectsFunctional alterationsBrain regionsSGK1 expressionSpine morphologyStress disorderFunction contributesBehavioral changesDisorders
2006
Antisocial personality and stress-induced brain activation in cocaine-dependent patients
Li CS, Kosten TR, Sinha R. Antisocial personality and stress-induced brain activation in cocaine-dependent patients. Neuroreport 2006, 17: 243-247. PMID: 16462591, DOI: 10.1097/01.wnr.0000199471.06487.a2.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsDistress processingBrain activationStress imageryAntisocial personalitySocialization scoresFunctional magnetic resonance imaging studyAbstinent cocaine-dependent individualsRegional brain activationStress-induced brain activationFemale participantsMedial prefrontal cortexMagnetic resonance imaging studyResonance imaging studyNeural correlatesLower socialization scoresCocaine-dependent patientsCorticolimbic brain regionsPrefrontal cortexImportant sex differencesBrain regionsPersonalityInterest analysisSignificant activationEffect size
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