2025
Uncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer’s disease continuum using the arterial spin labeling
Daneshpour A, Nasiri H, Motamed A, Heidarzadeh N, Fard A, Koleini S, Fakhimi F, Abiri L, Mayeli M, Sadeghi M. Uncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer’s disease continuum using the arterial spin labeling. Neurological Sciences 2025, 46: 2081-2090. PMID: 39838256, DOI: 10.1007/s10072-025-07992-4.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentSubjective memory complaintsMethodsWe analyzed dataAmyloid-betaDisease continuumAD participantsLinear regression modelsMultiple linear regression modelMemory complaintsRight inferior parietal cortexUnadjusted analysisCaudal middle frontal cortexRight lateral occipital cortexEducation levelAlzheimer's disease continuumCerebral blood flowAmyloid-beta accumulationArterial spin labelingLeft pars triangularisMiddle frontal cortexInferior parietal cortexAD dementiaLateral occipital cortexHigher cognitive functionsCognitive declineEarly-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study
Roberts A, Qiu X, McAlaine K, Germine L, Rotem R, Weisskopf M. Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study. Scientific Reports 2025, 15: 2105. PMID: 39814743, PMCID: PMC11736041, DOI: 10.1038/s41598-024-79083-x.Peer-Reviewed Original ResearchConceptsCognitively stimulating activitiesVisual short-term memoryCognitive functionWorking memoryShort-term memoryProcessing speedTests of crystallized intelligenceAssociated with specific cognitive domainsSpecific cognitive domainsVisual working memoryAssociated with higher cognitive functionOverall cognitive functionHigher cognitive functionsAssociated with overall cognitionLate-life cognitive functionAssociated with higher cognitive scoresCognitive controlEpisodic memoryVerbal reasoningCognitive domainsHigher cognitive scoresSustained attentionAssociated with activationOverall cognitionCognitive tests
2023
Origin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original Research
2022
Differences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach
Chien YL, Chen YJ, Tseng WL, Hsu YC, Wu CS, Tseng WI, Gau SS. Differences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach. Autism 2022, 27: 1036-1052. PMID: 36254873, DOI: 10.1177/13623613221125620.Peer-Reviewed Original ResearchConceptsNon-autistic siblingsNon-autistic peopleAutistic peopleAutistic traitsBrain regionsTheory of mindNon-autistic participantsHigher cognitive functionsAnterior brain regionsSocial cognitionNeurocognitive strengthsNeuropsychological characteristicsCognitive functionAutistic malesDifferent brain regionsAutismBrain adaptationIntermediate phenotype approachWhite matter differencesFuture researchNeural pathwaysBiological basisPeopleSiblingsCausal linkAttentional orienting abilities in bilinguals: Evidence from a large infant sample
Arredondo MM, Aslin RN, Zhang M, Werker JF. Attentional orienting abilities in bilinguals: Evidence from a large infant sample. Infant Behavior And Development 2022, 66: 101683. PMID: 34999429, PMCID: PMC8842846, DOI: 10.1016/j.infbeh.2021.101683.Peer-Reviewed Original ResearchConceptsBilingual cognitive advantageOrienting of attentionSignificant developmental gainsHigher cognitive functionsBilingual infantsOrienting tasksCognitive advantagesInfants' performanceCognitive developmentDevelopmental gainsInfluence infantsBilingual environmentLongitudinal subsetLarge sampleCurrent studyInfant samplesOrientingBilingualsInconclusive evidenceTaskSmall samplesInfantsPerformanceEvidenceKey questions
2021
Bilingualism alters infants’ cortical organization for attentional orienting mechanisms
Arredondo MM, Aslin RN, Werker JF. Bilingualism alters infants’ cortical organization for attentional orienting mechanisms. Developmental Science 2021, 25: e13172. PMID: 34418259, PMCID: PMC11225098, DOI: 10.1111/desc.13172.Peer-Reviewed Original ResearchConceptsBrain activityFrontal regionsValid trialsNon-linguistic cognitive functionsAttentional orienting mechanismsGreater brain activityEarly language experienceCortical organizationHigher cognitive functionsBilateral frontal regionsInvalid trialsAttention taskLanguage experienceOrienting mechanismTask performanceGreater activityBilingual environmentCognitive functionInfant brainNeural activityBrain structuresParent reportingMonolingualsBilingualsBilingualism
2019
A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders
Duque A, Spector R. A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders. Brain Structure And Function 2019, 224: 2281-2295. PMID: 31278571, PMCID: PMC6852840, DOI: 10.1007/s00429-019-01917-6.Peer-Reviewed Original ResearchConceptsAdult human brainAdult neurogenesisHuman brainAdult human neurogenesisNormal neuronal circuitsBrain homeostatic systemsNeural stem cellsDentate gyrusBrain neuronsAdult brainCertain drugsNeuronal circuitsHigher cognitive functionsNeuropsychiatric disordersCognitive functionNeurogenesisHuman neurogenesisBrainHomeostatic systemNeuronsStem cellsRecent studiesPrevention of damageDifferent stimuliHumans
2017
Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study
Singh K, Trivedi R, Verma A, D'souza M, Koundal S, Rana P, Baishya B, Khushu S. Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study. NMR In Biomedicine 2017, 30 PMID: 28759166, DOI: 10.1002/nbm.3764.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryDay 1Metabolic alterationsDay 5Moderate traumatic brain injuryPathological processesN-acetylaspartate levelsTrauma-induced changesSeverity of injuryProton magnetic resonance spectroscopy dataRat hippocampusGlutamine/glutamateHippocampus regionTBI groupAltered metabolitesHigher cognitive functionsCognitive functionInjuryMetabolic irregularitiesAmino acid metabolismCitric acid cycle intermediatesAltered levelsMetabolic profileOxidative stressImpaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry 2017, 81: 874-885. PMID: 28434616, PMCID: PMC5407407, DOI: 10.1016/j.biopsych.2017.01.004.Peer-Reviewed Original ResearchConceptsNeural activityNeural ensemblesComputational neuroscience perspectiveHigher cognitive functionsNeuroscience perspectiveDevelopmental perspectiveDevelopmental correlatesCognitive functionNegative functional consequencesCortical networksComputational neuroscienceNeural codeCortical activityCognitive impairmentNeural dysfunctionAspartate glutamate receptor antagonistTemporal tuningSpatial tuningGlutamate receptor antagonistsPathophysiology of schizophreniaNeural network functionSchizophreniaPsychiatric disordersBalance of excitationInput-output curves
2015
Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function
Berridge C, Arnsten A. Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function. Current Opinion In Behavioral Sciences 2015, 4: 33-40. DOI: 10.1016/j.cobeha.2015.01.002.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPharmacological treatmentCognitive dysfunctionPrefrontal cognitive dysfunctionCognition-enhancing effectsMultiple psychiatric disordersSpecific intracellular pathwaysDeficit hyperactivity disorderPrefrontal catecholaminesClinical efficacyCatecholamine mechanismsADHD medicationNovel medicationsReceptor mechanismsPrefrontal cognitionPsychiatric disordersCatecholamine receptorsCatecholamine modulationHigher cognitive functionsCognitive functionPrefrontal cortexHyperactivity disorderImproved treatmentIntracellular pathwaysKey modulator
2014
Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy
Benjamin CF, Saling MM, Wood AG, Reutens DC. Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy. PLOS ONE 2014, 9: e100891. PMID: 24978828, PMCID: PMC4076213, DOI: 10.1371/journal.pone.0100891.Peer-Reviewed Original ResearchConceptsMTL damageAssociation formationAssociative processingTemporal lobe epilepsyMesial temporal lobe damageNovel fMRI taskCognitive neuropsychological modelGroup whole-brain analysesLeft Temporal Lobe EpilepsyMesial temporal lobeSimple visual stimuliTemporal lobe damageHigher cognitive functionsWhole-brain analysisReorganization of networksMore fundamental processesNeuropsychological modelFMRI taskMTL functionParahippocampal activationTypical adultsAssociative processesMTL structuresBehavioral performanceVisual stimuli
2006
Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia
Mohamed S, Bondi MW, Kasckow JW, Golshan S, Jeste DV. Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia. International Journal Of Geriatric Psychiatry 2006, 21: 711-718. PMID: 16862606, DOI: 10.1002/gps.1528.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceSchizophrenia patientsCognitive statusAlcohol useHigher cognitive functionsWorse cognitive scoresQuality of lifeYounger schizophrenia patientsOlder groupNeuropsychological functioningNeurocognitive functioningCognitive functionCognitive scoresWorse cognitionIntervention researchCognitionDiagnosis of schizophreniaSame-aged groupPsychopathologic assessmentSchizoaffective disorderSymptom profilesLater lifeAge groupsSchizophrenia
2005
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Benavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.Peer-Reviewed Original ResearchConceptsHuman temporal cortexPyramidal cellsPyramidal neuronsCatecholaminergic innervationCatecholaminergic afferentsCatecholaminergic fibersTyrosine hydroxylaseTemporal cortexHuman neocortexBasal dendritic regionsBasal dendritic arborsHuman cortical organizationEnzyme tyrosine hydroxylaseHuman cortical tissueDendritic arborsExcitatory inputsCortical functionLayers IIHigher cognitive functionsLayers IIIaCognitive functionDendritic compartmentsCortical tissueCortical organizationLucifer YellowNeural circuitry of judgment and decision mechanisms
Opris I, Bruce CJ. Neural circuitry of judgment and decision mechanisms. Brain Research Reviews 2005, 48: 509-526. PMID: 15914255, DOI: 10.1016/j.brainresrev.2004.11.001.Peer-Reviewed Original ResearchConceptsDecision formationNeural circuitrySystems neuroscience approachHigher cognitive functionsOptimal behavioral responseNeuroscience approachResponse selectionReward expectationDecision mechanismCognitive functionNeural activitySensory inputBehavioral outputPrimate brainPrior experienceBehavioral responsesSubcortical areasDeliberation processCortical loopDecision circuitCircuitryJudgmentsDynamic interactionActivation thresholdSelection bias
2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampus
1999
(Non)stationarity of temporal dynamics in fMRI
Calhoun V, Adali T, Pearlson G. (Non)stationarity of temporal dynamics in fMRI. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 1999, 2: 1079 vol.2. DOI: 10.1109/iembs.1999.804239.Peer-Reviewed Original ResearchPrimary visual cortexFunctional MRIHemodynamic responseVisual cortexBrain regionsObserved hemodynamic responsesBlood supplyHigher cognitive functionsCognitive functionLatency shiftNeuronal patternsCortexAuthors' initial resultsCurrent studyFMRI experimentMean waveformOverall changeInitial resultsMRI
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