2017
Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study
Singh K, Trivedi R, Verma A, D'souza M, Koundal S, Rana P, Baishya B, Khushu S. Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study. NMR In Biomedicine 2017, 30 PMID: 28759166, DOI: 10.1002/nbm.3764.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryDay 1Metabolic alterationsDay 5Moderate traumatic brain injuryPathological processesN-acetylaspartate levelsTrauma-induced changesSeverity of injuryProton magnetic resonance spectroscopy dataRat hippocampusGlutamine/glutamateHippocampus regionTBI groupAltered metabolitesHigher cognitive functionsCognitive functionInjuryMetabolic irregularitiesAmino acid metabolismCitric acid cycle intermediatesAltered levelsMetabolic profileOxidative stress
1992
Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients.
Graham G, Blamire A, Howseman A, Rothman D, Fayad P, Brass L, Petroff O, Shulman R, Prichard J. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 1992, 23: 333-340. PMID: 1542892, DOI: 10.1161/01.str.23.3.333.Peer-Reviewed Original ResearchConceptsProton magnetic resonance spectroscopyStroke patientsCerebral lactateDeep cerebral infarctsElevated cerebral lactateSmall subcortical infarctsCortical stroke patientsN-acetylaspartate levelsLong-term elevationCerebral infarctsCortical strokeOngoing ischemiaSymptom onsetBrain lactateElevated lactateInitial insultSubcortical infarctsN-acetylaspartateInfarct regionLesion onsetMagnetic resonance spectroscopyInfarctsPatientsFirst weekStroke
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