2021
A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial
Dylla L, Douin D, Anderson E, Rice J, Jackson C, Bebarta V, Lindsell C, Cheng A, Schauer S, Ginde A. A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. Trials 2021, 22: 784. PMID: 34749762, PMCID: PMC8574946, DOI: 10.1186/s13063-021-05688-6.Peer-Reviewed Original ResearchConceptsCritically Ill Trauma PatientsImplementation trialStatistical analysis planMultimodal interventionTrauma patientsTraining periodStudy protocolTargeted normoxiaVentilator-free daysOne-month training periodGlasgow Outcome ScoreAnalysis planLevel 1 trauma centerCombat casualty careUsual carePre-implementationInjured trauma patientsSupplemental oxygenPost-implementationReduced logistical burdensIntervention phaseOutcome measuresCasualty careMulticenter clusterOutcome scores
2018
Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage
Zafar SF, Postma EN, Biswal S, Boyle EJ, Bechek S, O'Connor K, Shenoy A, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage. Clinical Neurophysiology 2018, 129: 2219-2227. PMID: 30212805, PMCID: PMC6478499, DOI: 10.1016/j.clinph.2018.08.015.Peer-Reviewed Original ResearchConceptsAnti-epileptic drugsAneurysmal subarachnoid hemorrhageEpileptiform abnormalitiesWorse outcomesSubarachnoid hemorrhageHigh-grade aSAH patientsEvidence-based treatment protocolsGlasgow Outcome ScoreAntiepileptic drug managementStandard prophylaxisNeurologic outcomeProphylactic protocolASAH patientsOutcome scoresDrug managementHigh burdenRetrospective analysisTreatment protocolOutcome measuresPatientsDaily burdenRhythmic activityFirst dayOutcomesBurden
2016
Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage
Murthy S, Caplan J, Levy A, Pradilla G, Moradiya Y, Schneider E, Shalom H, Ziai W, Tamargo R, Nyquist P. Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2016, 78: 71-76. PMID: 26348010, DOI: 10.1227/neu.0000000000001000.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageCerebral infarctionSubarachnoid hemorrhageHp genotypeHp 2Cerebral Salt Wasting SyndromeGlasgow Outcome ScoreCerebral saltUrine sodiumBaseline characteristicsSymptomatic vasospasmIndependent predictorsUrine outputClinical outcomesOutcome scoresSubsequent vasospasmFunctional outcomeProspective confirmationMultivariate regression modelGenotype testingHaptoglobin 2Haptoglobin genotypeOutcome measuresHemorrhagePatients
2013
Effect of cocaine use on outcomes in traumatic brain injury
Yeung JT, Williams J, Bowling WM. Effect of cocaine use on outcomes in traumatic brain injury. Journal Of Emergencies Trauma And Shock 2013, 6: 189-194. PMID: 23960376, PMCID: PMC3746441, DOI: 10.4103/0974-2700.115337.Peer-Reviewed Original ResearchGlasgow Outcome ScoreTraumatic brain injuryBrain injuryPre-existing brain pathologyLevel 1 trauma centerMin of admissionBlunt head traumaInstitutional review board approvalReview board approvalLower mortality rateHospital LOSHospital mortalityHospital lengthPositive patientsRetrospective cohortSecondary outcomesCerebral ischemiaPrimary outcomeUnscreened groupHead traumaNeuroprotective effectsTrauma centerTrauma registryOutcome scoresBrain pathology
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