2020
mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Karam BS, Morris RS, Bramante CT, Puskarich M, Zolfaghari EJ, Lotfi‐Emran S, Ingraham NE, Charles A, Odde DJ, Tignanelli CJ. mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses. Journal Of Medical Virology 2020, 93: 1843-1846. PMID: 33314219, PMCID: PMC8159020, DOI: 10.1002/jmv.26728.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus 2 infectionReview of efficacyCoronavirus disease 2019Modulation of mTORSARS-CoV-2RNA virusesDisease 2019Recent evidence pointsMTOR inhibitorsViral infectionMTOR inhibitionMTOR pathwayMammalian targetRapamycin (mTOR) pathwayNumerous RNA virusesVirus growthCOVID-19MTOR resultsInfectionCurrent literatureHighlight evidenceEvidence pointsRibosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver
Farley‐Barnes K, Baserga S. Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver. 2020, 174-182. DOI: 10.1002/9781119436812.ch15.ChaptersRibosome biogenesisBiogenesis of ribosomesProduction of ribosomesHuman ribosome biogenesisCell growthTumor suppressor p53Cellular cuesNumerous proteinsNucleolar stressRegulated processTranscription factorsBiogenesisNutrient availabilityKey regulatorMechanistic targetSuppressor p53Rapamycin (mTOR) pathwayRibosomesRegulationProliferationSuch diseasesMYCRegulatorCytoplasmProtein
2019
GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations
Iffland PH, Carson V, Bordey A, Crino PB. GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations. Epilepsia 2019, 60: 2163-2173. PMID: 31625153, PMCID: PMC7155771, DOI: 10.1111/epi.16370.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCellular amino acid levelsRegulatory gene mutationsActivator RhebAmino acid levelsProtein complexesSingle geneRegulatory proteinsGene mutationsMechanistic targetNPRL3Rapamycin (mTOR) pathwayMTOR activationMTOR pathwayMutationsNPRL2MTOR inhibitionGenesFocal cortical dysplasia type IIaMTORDEPDC5ProteinPivotal rolePathwayRecent studiesNeuronal excitability
2015
New targets in breast cancer
Jhaveri A, Pusztai L. New targets in breast cancer. Memo - Magazine Of European Medical Oncology 2015, 8: 86-91. DOI: 10.1007/s12254-015-0197-5.Peer-Reviewed Original ResearchBreast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Novel clinical trial designsGrowth factor receptor 2Immune checkpoint modulatorsClinical trial designFactor receptor 2Akt/mammalian targetCyclin-dependent kinase 4/6Antibody-drug conjugatesPoly ADP-ribose polymeraseEndocrine therapyCheckpoint modulatorsADP-ribose polymeraseTherapeutic strategiesReceptor 2Trial designTherapeutic potentialMolecular abnormalitiesMammalian targetRapamycin (mTOR) pathwayNew drugsCancerNew targets
2013
Chapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish
Yuan S, Zhao L, Sun Z. Chapter Nine Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish. Methods In Enzymology 2013, 525: 159-189. PMID: 23522470, DOI: 10.1016/b978-0-12-397944-5.00009-2.Peer-Reviewed Original ResearchConceptsTOR pathwayCilia length controlGreen alga ChlamydomonasKupffer's vesiclePatterning defectsCiliary precursorsNutrient cuesCiliopathic phenotypesVertebrate modelTranslational regulationAlga ChlamydomonasCilia morphologyFunctional interplayEmbryonic organsFluid flow generationZebrafishCellular growthCilia lengthMajor regulatorChlamydomonasRapamycin (mTOR) pathwayLength controlCiliary motilityFundamental processesMechanistic relationship
2011
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2462-2467. PMID: 21262823, PMCID: PMC3038735, DOI: 10.1073/pnas.1011498108.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorRenal cystogenesisProtein kinaseAutosomal dominant polycystic kidney diseaseFibrosis transmembrane conductance regulatorTransmembrane conductance regulatorEpithelial cellsCyst epithelial cellsRenal cyst developmentCyst-lining epithelial cellsAMPK activationConductance regulatorRapamycin (mTOR) pathwayMammalian targetPharmacological activatorsChloride channelsMTOR pathwayCystogenesisCyst developmentKinaseAMPKContext of ADPKDSignificant arrestDominant polycystic kidney diseasePolycystic kidney disease
2010
An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G. An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness. Immunity 2010, 33: 929-941. PMID: 21145759, PMCID: PMC3133602, DOI: 10.1016/j.immuni.2010.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCell ProliferationCells, CulturedClonal AnergyDisease ProgressionEncephalomyelitis, Autoimmune, ExperimentalForkhead Transcription FactorsHumansInterleukin-2Interleukin-2 Receptor alpha SubunitLeptinMiceMice, Inbred C57BLSignal TransductionSirolimusT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesConceptsTreg cellsAnergic stateInterleukin-2Treg cell expansionRegulatory T cellsExogenous interleukin-2T cell responsivenessCell receptor stimulationImmune toleranceT cellsCell responsivenessReceptor stimulationMTOR activationEarly downregulationMammalian targetMTOR kinase activityRapamycin (mTOR) pathwayProliferative capabilityTransient inhibitionUnderlying mechanismElevated activityEnergy metabolismCellsResponsivenessCell expansionmTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists. Science 2010, 329: 959-964. PMID: 20724638, PMCID: PMC3116441, DOI: 10.1126/science.1190287.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsDendritic SpinesDepressionIntracellular Signaling Peptides and ProteinsKetamineMaleNeuronsNeuropeptidesPhenolsPiperidinesProtein BiosynthesisProtein Serine-Threonine KinasesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSignal TransductionSirolimusSynapsesTime FactorsTOR Serine-Threonine KinasesConceptsTreatment-resistant depressed patientsBlockade of mTORFast antidepressant actionAction of ketamineRapid antidepressant effectsRapid antidepressant responseEffects of ketamineModel of depressionAntidepressant actionAntidepressant effectsAntidepressant responseKetamine inductionStandard medicationSynaptic deficitsKetamine administrationDepressed patientsSpine synapsesNMDA antagonistsMood disordersSynapse formationKetamineMammalian targetPrefrontal cortexRapamycin (mTOR) pathwayPossible new approach
2000
Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*
Martin K, Schalm S, Richardson C, Romanelli A, Keon K, Blenis J. Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*. Journal Of Biological Chemistry 2000, 276: 7884-7891. PMID: 11108711, DOI: 10.1074/jbc.m006969200.Peer-Reviewed Original ResearchConceptsProtein kinase CzetaC-terminusPhosphoinositide-dependent kinase 1Ribosomal S6 kinase 2S6 kinase 2PI3K effectorsRibosomal S6 kinaseRibosomal protein S6Agonist-dependent activationS6 kinaseProtein S6Kinase activityKinase 2Kinase 1Translational capacityS6K2Terminal sequencePhysiological roleImportant regulatorRapamycin (mTOR) pathwayMammalian targetS6K1Basal activationTerminusHomolog
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