2025
Direct genetic transformation bypasses tumor-associated DNA methylation alterations
Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar M, Leyvraz S, Keilholz U, Yaspo M, Regev A, Kretzmer H, Smith Z, Meissner A. Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biology 2025, 26: 212. PMID: 40676699, PMCID: PMC12273271, DOI: 10.1186/s13059-025-03650-2.Peer-Reviewed Original ResearchConceptsDe novo methylationEpigenetic aspectsDNA methylation landscapeDNA methylation alterationsDNA methylation levelsMethylation landscapeMutant cellsPromoter sequencesExtensive proliferation in vitroMethylation alterationsCellular transformationMethylation levelsHuman cellsGenetic transformationGlobal changeHealthy human cellsClinical samplesAnimal systemsConclusionsOur resultsMolecular referenceProliferation in vitroCellsMouse modelTumor modelDNA
2020
Cutting-edge genetics in obsessive-compulsive disorder
Saraiva L, Cappi C, Simpson H, Stein D, Viswanath B, van den Heuvel O, Reddy Y, Miguel E, Shavitt R. Cutting-edge genetics in obsessive-compulsive disorder. Faculty Reviews 2020, 9: 30. PMID: 33659962, PMCID: PMC7886082, DOI: 10.12703/r/9-30.Peer-Reviewed Original ResearchGenetic architectureWide association studyNumber variation studiesCutting-edge geneticsWhole-exome sequencing studiesUnderlying biological pathwaysHuman cell modelsGene networksStudy of endophenotypesGene expressionBiological pathwaysSequencing studiesAssociation studiesAnimal systemsGeneticsGene-environment interactionsCell modelBiological basisPolygenic risk scoresEvidence pointsSynaptic transmissionRecent advancesVariation studiesExperimental animal systemsNeuropsychiatric disorders
2001
Cell lineage, cell signaling and the control of plant morphogenesis
Irish V, Jenik P. Cell lineage, cell signaling and the control of plant morphogenesis. Current Opinion In Genetics & Development 2001, 11: 424-430. PMID: 11448629, DOI: 10.1016/s0959-437x(00)00213-6.Peer-Reviewed Original Research
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