2020
Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Ingram J, Funk S, Norton K, Lane H, Bennett C, Dunn A, Recht M, Shapiro A, Manco-Johnson M. Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study. Blood Advances 2020, 4: 2451-2459. PMID: 32492157, PMCID: PMC7284094, DOI: 10.1182/bloodadvances.2019001311.Peer-Reviewed Original ResearchConceptsSevere hemophilia AHemophilia AFactor VIIIDelayed prophylaxisMagnetic resonance imagingRandomized to prophylaxisHigh-titer inhibitorsAnnualized bleeding rateInitiation of prophylaxisJoint damageReduce joint damagePhysical examination scoresProphylactic factor VIIIAge 6 yearsRandomized Controlled TrialsProphylaxis groupEarly prophylaxisSevere HARetrospective studyEpisodic treatmentProphylaxisPrimary outcomeDelayed initiationOdds ratioSecondary outcomes
2018
Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Funk S, Lane H, Bennett C, Shapiro A, Recht M, Manco-Johnson M. Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study. Blood 2018, 132: 382. DOI: 10.1182/blood-2018-99-117413.Peer-Reviewed Original ResearchEntity's Board of DirectorsSevere hemophilia AHemophilia AEarly prophylaxisPhysical exam scoresEpisodic treatmentDelayed prophylaxisProphylaxis armJoint damageFactor VIIIIndex jointMagnetic resonance imaging scalesPrevent joint diseaseOsteochondral damageFactor VIII prophylaxisJoint bleeding episodesSoft tissue changesRisk of joint damageRisk of soft tissue damageInitial treatment groupAdvisory CommitteeProphylactic factor VIIIAge 6 yearsTiter inhibitorsRandomized Controlled Trials
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply