Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc)
Manco-Johnson M, Manco-Johnson M, Blades T, Funk S, Lane H, McRedmond K, Dunn A, Recht M, Shapiro A, Valentino L, Brown D. Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc). Blood 2013, 122: 210. DOI: 10.1182/blood.v122.21.210.210.Peer-Reviewed Original ResearchAge 6 yearsMagnetic resonance imagingInitiation of prophylaxisIndex jointEpisodic therapyCSL BehringPhysical examinationSevere factor VIII deficiencySevere hemophilia AFactor VIII deficiencyRandomized controlled clinical trialResponse to bleedingAdvisory CommitteeMonths of ageProphylaxis therapyEarly prophylaxisProphylaxis initiationHemophilia AProphylaxis adherenceProphylaxisClinical trialsFactor VIIIDelayed initiationAffected boneQuality of life
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