2020
Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Ingram J, Funk S, Norton K, Lane H, Bennett C, Dunn A, Recht M, Shapiro A, Manco-Johnson M. Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study. Blood Advances 2020, 4: 2451-2459. PMID: 32492157, PMCID: PMC7284094, DOI: 10.1182/bloodadvances.2019001311.Peer-Reviewed Original ResearchConceptsSevere hemophilia AHemophilia AFactor VIIIDelayed prophylaxisMagnetic resonance imagingRandomized to prophylaxisHigh-titer inhibitorsAnnualized bleeding rateInitiation of prophylaxisJoint damageReduce joint damagePhysical examination scoresProphylactic factor VIIIAge 6 yearsRandomized Controlled TrialsProphylaxis groupEarly prophylaxisSevere HARetrospective studyEpisodic treatmentProphylaxisPrimary outcomeDelayed initiationOdds ratioSecondary outcomes
2019
Factor VIII prophylaxis effects outweigh other hemostasis contributors in predicting severe haemophilia A joint outcomes
Warren B, Jacobson L, Kempton C, Buchanan G, Recht M, Brown D, Leissinger C, Shapiro A, Abshire T, Manco‐Johnson M, Investigators F. Factor VIII prophylaxis effects outweigh other hemostasis contributors in predicting severe haemophilia A joint outcomes. Haemophilia 2019, 25: 867-875. PMID: 31115111, PMCID: PMC7273872, DOI: 10.1111/hae.13778.Peer-Reviewed Original ResearchConceptsFactor VIIITreatment armsGlobal assaysGlobal assays of coagulationFactor VIII half-lifeUnivariate logistic regression analysisFVIII half-lifeAged 6Treatment adherenceAssays of coagulationPresence of subchondral cystsProphylactic factor VIIILogistic regression analysisFVIII infusionHalf-lifeAssociation of variablesJoint-space narrowingHemophilia AUntreated childrenOutcome parametersSevere haemophiliaProphylaxis effectAnticoagulant proteinsLogistic regressionSubchondral cysts
2018
Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Funk S, Lane H, Bennett C, Shapiro A, Recht M, Manco-Johnson M. Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study. Blood 2018, 132: 382. DOI: 10.1182/blood-2018-99-117413.Peer-Reviewed Original ResearchEntity's Board of DirectorsSevere hemophilia AHemophilia AEarly prophylaxisPhysical exam scoresEpisodic treatmentDelayed prophylaxisProphylaxis armJoint damageFactor VIIIIndex jointMagnetic resonance imaging scalesPrevent joint diseaseOsteochondral damageFactor VIII prophylaxisJoint bleeding episodesSoft tissue changesRisk of joint damageRisk of soft tissue damageInitial treatment groupAdvisory CommitteeProphylactic factor VIIIAge 6 yearsTiter inhibitorsRandomized Controlled Trials
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply