2022
Single agent PD-1 blockade as curative-intent treatment in mismatch repair deficient locally advanced rectal cancer.
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Stadler Z, Yaeger R, Smith J, Saltz L, El Dika I, Crane C, Romesser P, Iyer K, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser M, Schalper K, Diaz L. Single agent PD-1 blockade as curative-intent treatment in mismatch repair deficient locally advanced rectal cancer. Journal Of Clinical Oncology 2022, 40: lba5-lba5. DOI: 10.1200/jco.2022.40.17_suppl.lba5.Peer-Reviewed Original ResearchPD-1 blockadeAdvanced rectal cancerSingle-agent PD-1 blockadeClinical complete responseRectal cancerCo-primary endpointsComplete responseAnti-PD-1 monoclonal antibodyProspective phase II studyPD-1 monoclonal antibodyMismatch repair-deficient colorectal cancersCurative-intent treatmentPhase II studySerious adverse eventsCase of progressionEvidence of tumorDigital rectal examDeficient colorectal cancerMetastatic settingNeoadjuvant chemotherapyAdverse eventsCheckpoint blockadeII studySurgical resectionRectal adenocarcinoma
2020
The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer
Lynch S, Handorf E, Sorice K, Blackman E, Bealin L, Giri V, Obeid E, Ragin C, Daly M. The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer. PLOS ONE 2020, 15: e0237332. PMID: 32790761, PMCID: PMC7425919, DOI: 10.1371/journal.pone.0237332.Peer-Reviewed Original ResearchConceptsProstate-specific antigenPCa family historyHigh-risk menProbability of PCaFamily historyPCa diagnosisRisk menWhite menDigital rectal examEarly Detection ProgramClinical risk assessmentProstate cancer disparitiesProstate cancer developmentPatient risk assessmentNeighborhood socioeconomic factorsPatient-level modelsCox regressionRectal examBaseline ageCancer disparitiesPatient variablesProstate cancerHigh riskNeighborhood social environmentClinical relevance
2019
Organ preservation in rectal cancer patients treated with total neoadjuvant therapy.
Jimenez-Rodriguez R, Quezada-Diaz F, Hameed I, Patil S, Smith J, Garcia-Aguilar J. Organ preservation in rectal cancer patients treated with total neoadjuvant therapy. Journal Of Clinical Oncology 2019, 37: 692-692. DOI: 10.1200/jco.2019.37.4_suppl.692.Peer-Reviewed Original ResearchTotal neoadjuvant therapyClinical complete responseTotal mesorectal excisionRectal cancer patientsRelapse-free survivalComplete responseCancer patientsWW groupTME patientsNeoadjuvant therapyTreatment strategiesStage II/III rectal adenocarcinomaStage II/III rectal cancerIncomplete clinical responseLocal tumor regrowthPathological complete responseMedian radiation doseRetrospective case seriesKaplan-Meier analysisDigital rectal examRank sum testWW patientsChemotherapy cyclesClinical responseConsecutive patients
2015
Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review
Leone A, Gershman B, Rotker K, Butler C, Fantasia J, Miller A, Afiadata A, Amin A, Zhou A, Jiang Z, Sebo T, Mega A, Schiff S, Pareek G, Golijanin D, Yates J, Karnes RJ, Renzulli J. Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review. Prostate Cancer And Prostatic Diseases 2015, 19: 68-71. PMID: 26857145, DOI: 10.1038/pcan.2015.52.Peer-Reviewed Original ResearchConceptsAtypical small acinar proliferationHigh-grade prostate cancerImmediate repeat biopsySmall acinar proliferationMulti-institutional reviewRepeat biopsySubsequent prostate cancerProstate cancerAcinar proliferationInitial diagnosisProstate biopsyRetrospective multi-institutional reviewAbnormal digital rectal examTransrectal ultrasound-guided biopsyPre-biopsy PSAHigh-grade diseaseDigital rectal examUltrasound-guided biopsyUnderwent repeat biopsyMajority of menElevated PSAGleason 7Clinicopathologic featuresRectal examHigher PSA
2005
Reasons to Omit Digital Rectal Exam in Trauma Patients: No Fingers, No Rectum, No Useful Additional Information
Esposito TJ, Ingraham A, Luchette FA, Sears BW, Santaniello JM, Davis KA, Poulakidas SJ, Gamelli RL. Reasons to Omit Digital Rectal Exam in Trauma Patients: No Fingers, No Rectum, No Useful Additional Information. Journal Of Trauma And Acute Care Surgery 2005, 59: 1314-1319. PMID: 16394903, DOI: 10.1097/01.ta.0000198375.83830.62.Peer-Reviewed Original ResearchConceptsDigital rectal examinationSpinal cord injuryGlasgow Coma Scale scoreIndex injuryDRE findingsTrauma patientsGastrointestinal bleedingUrethral disruptionInjury casesPredictive valueSecondary surveyRoutine digital rectal examinationLevel I trauma centerI trauma centerDigital rectal examNegative predictive valuePositive predictive valueAdvanced Trauma Life Support (ATLS) courseInitial evaluation processLife support courseProspective studyRectal examRectal examinationTrauma centerCord injury
2002
Effectiveness of screening for prostate cancer A nested case-control study
Concato J, Wells C, Penson D, Horwitz R, Peduzzi P. Effectiveness of screening for prostate cancer A nested case-control study. Journal Of Clinical Epidemiology 2002, 55: 630. DOI: 10.1016/s0895-4356(02)00422-5.Peer-Reviewed Original ResearchDigital rectal examProstate-specific antigenProstate cancerControl subjectsOdds ratioEffectiveness of PSAAssessment of ScreeningUnadjusted odds ratioCase-control studyVA Medical CenterYears of intakePotential screening testYears of ageCase-control designTime of deathYear of birthPSA testingImproved survivalRectal examMedical CenterAmbulatory careCase-control statusCase subjectsVA facilitiesScreening test
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