2022
A prospective trial of treatment de-escalation following neoadjuvant paclitaxel/trastuzumab/pertuzumab in HER2-positive breast cancer
Waks AG, Desai NV, Li T, Poorvu PD, Partridge AH, Sinclair N, Spring LM, Faggen M, Constantine M, Metzger O, Alberti J, Deane J, Rosenberg SM, Frank E, Tolaney SM, Krop IE, Tung NM, Tayob N, King TA, Mittendorf EA, Winer EP. A prospective trial of treatment de-escalation following neoadjuvant paclitaxel/trastuzumab/pertuzumab in HER2-positive breast cancer. Npj Breast Cancer 2022, 8: 63. PMID: 35538105, PMCID: PMC9091255, DOI: 10.1038/s41523-022-00429-7.Peer-Reviewed Original ResearchPathologic complete responseProspective trialBreast cancerSingle-arm prospective trialHER2-positive breast cancerHuman epidermal growth factor receptorAdjuvant treatment plansDose of THPEarly-stage HER2Incomplete clinical responsePrimary feasibility endpointTrastuzumab/pertuzumabMajority of patientsOngoing prospective trialsStage II tumorsLong-term efficacyBreast cancer recurrenceEpidermal growth factor receptorAdjuvant chemotherapyFeasibility endpointsGrowth factor receptorNeoadjuvant regimenAdjuvant therapyDoublet therapyPrimary endpoint
2019
Organ preservation in rectal cancer patients treated with total neoadjuvant therapy.
Jimenez-Rodriguez R, Quezada-Diaz F, Hameed I, Patil S, Smith J, Garcia-Aguilar J. Organ preservation in rectal cancer patients treated with total neoadjuvant therapy. Journal Of Clinical Oncology 2019, 37: 692-692. DOI: 10.1200/jco.2019.37.4_suppl.692.Peer-Reviewed Original ResearchTotal neoadjuvant therapyClinical complete responseTotal mesorectal excisionRectal cancer patientsRelapse-free survivalComplete responseCancer patientsWW groupTME patientsNeoadjuvant therapyTreatment strategiesStage II/III rectal adenocarcinomaStage II/III rectal cancerIncomplete clinical responseLocal tumor regrowthPathological complete responseMedian radiation doseRetrospective case seriesKaplan-Meier analysisDigital rectal examRank sum testWW patientsChemotherapy cyclesClinical responseConsecutive patients
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