2023
Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension
Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai E, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L. Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. Circulation Research 2023, 133: 508-531. PMID: 37589160, DOI: 10.1161/circresaha.122.321200.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionHypoxic pulmonary hypertensionPulmonary endothelial functionHuman pulmonary artery endothelial cellsPulmonary artery endothelial cellsPulmonary endotheliumArtery endothelial cellsEndothelial functionEndothelial cellsEndothelial mitochondriaSugen/hypoxia rat modelClinical specimensPulmonary endothelial dysfunctionHypoxia rat modelPulmonary arterial systemHypoxic stressVascular remodeling diseasePrevious clinical researchHuman embryonic stem cell-derived endothelial cellsMitochondrial oxygen consumption rateIntrinsic pathogenesisEndothelial dysfunctionExtracellular acidification rateHypoxic ratsPoor prognosis
2001
Chronic hypoxia modulates diaphragm function in the developing rat
Kass LJ, Bazzy AR. Chronic hypoxia modulates diaphragm function in the developing rat. Journal Of Applied Physiology 2001, 90: 2325-2329. PMID: 11356799, DOI: 10.1152/jappl.2001.90.6.2325.Peer-Reviewed Original ResearchConceptsOne-half relaxation timeNeuromuscular transmissionNerve stimulationChronic hypoxiaContraction timePhrenic nerve-hemidiaphragm preparationAge-matched controlsLower specific forceHypoxic diaphragmDiaphragm functionHemidiaphragm preparationHypoxic ratsHypoxic groupSpecific forceContractile propertiesControl groupRat diaphragmMaturation of mechanismsRatsGreater decreaseStimulationHypoxiaDiaphragmHypoxicDelays maturation
1997
Chronic postnatal hypoxia increases the numbers of cortical neurons
Stewart W, Ment L, Schwartz M. Chronic postnatal hypoxia increases the numbers of cortical neurons. Brain Research 1997, 760: 17-21. PMID: 9237513, DOI: 10.1016/s0006-8993(97)00271-0.Peer-Reviewed Original ResearchConceptsCortical neuronsHypoxic ratsSublethal hypoxiaChronic postnatal hypoxiaChronic sublethal hypoxiaDays of hypoxiaCell deathPostnatal hypoxiaPremature infantsNeuronal densityBrain weightChronic hypoxiaCortical volumeClinical problemAnimal modelsCortical cell deathRatsThird dayHypoxiaLower bodyNeurodevelopmental disordersNeuronsConsiderable evidenceProlonged periodDeath
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