2021
Hemoglobin A1c Patterns of Youth With Type 1 Diabetes 10 Years Post Diagnosis From 3 Continents
Sherr JL, Schwandt A, Phelan H, Clements MA, Holl RW, Benitez-Aguirre PZ, Miller KM, Woelfle J, Dover T, Maahs DM, Fröhlich-Reiterer E, Craig ME. Hemoglobin A1c Patterns of Youth With Type 1 Diabetes 10 Years Post Diagnosis From 3 Continents. 2021, 148: e2020048942. PMID: 34315809, PMCID: PMC8785705, DOI: 10.1542/peds.2020-048942.Peer-Reviewed Original Research
2020
Changes in Device Uptake and Glycemic Control Among Pregnant Women With Type 1 Diabetes: Data From the T1D Exchange
Levy CJ, Foster NC, DuBose SN, Agarwal S, Lyons SK, Peters AL, Uwaifo GI, DiMeglio LA, Sherr JL, Polsky S. Changes in Device Uptake and Glycemic Control Among Pregnant Women With Type 1 Diabetes: Data From the T1D Exchange. Journal Of Diabetes Science And Technology 2020, 15: 1297-1302. PMID: 33218278, PMCID: PMC8655289, DOI: 10.1177/1932296820972123.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionPregnant womenEligible participantsCohort 2Continuous glucose monitorGlycemic outcomesT1D Exchange Clinic RegistryDevice useSubcutaneous insulin infusionHemoglobin A1c resultsT1D pregnancyGlycemic controlClinic registryT1D ExchangeCSII useA1C resultsInsulin infusionMedical recordsCohort 1CGM useType 1Device uptakeWomenSurvey completionAdditional evaluation
2019
1424-P: Changes in Device Uptake and Glycemic Control among Pregnant Women with Type 1 Diabetes: Data from the T1D Exchange
LEVY C, FOSTER N, DUBOSE S, AGARWAL S, LYONS S, PETERS A, UWAIFO G, DIMEGLIO L, SHERR J, POLSKY S. 1424-P: Changes in Device Uptake and Glycemic Control among Pregnant Women with Type 1 Diabetes: Data from the T1D Exchange. Diabetes 2019, 68 DOI: 10.2337/db19-1424-p.Peer-Reviewed Original ResearchPregnant womenMannKind CorporationSanofi USKidney diseaseDiabetes FoundationPump useT1D Exchange Clinic RegistryEli LillyLexicon PharmaceuticalsBarbara Davis CenterInsulin pump useCohort of womenType 1 diabetesReal-world populationNational InstituteAdvisory PanelHelmsley Charitable TrustHealth researchPregnancy outcomesGlycemic controlSevere hypoglycemiaClinic registrySelf-reported useT1D ExchangeNovo Nordisk A/S2418-PUB: Incident Diabetes Complications among Women with T1D Based on Parity
POLSKY S, FOSTER N, DUBOSE S, AGARWAL S, LYONS S, PETERS A, UWAIFO G, DIMEGLIO L, SHERR J, LEVY C. 2418-PUB: Incident Diabetes Complications among Women with T1D Based on Parity. Diabetes 2019, 68 DOI: 10.2337/db19-2418-pub.Peer-Reviewed Original ResearchStudy enrollmentMannKind CorporationSanofi USKidney diseaseDiabetes FoundationT1D Exchange Clinic RegistryCardiovascular disease risk factorsEli LillyRate of neuropathyDisease risk factorsDiabetes-related complicationsLexicon PharmaceuticalsBarbara Davis CenterBody mass indexType 1 diabetesNational InstituteAdvisory PanelHelmsley Charitable TrustHealth researchYear of enrollmentRace/ethnicityPreg groupPregnant cohortClinic registryMass index
2018
Eligibility for clinical trials is limited for youth with type 2 diabetes: Insights from the Pediatric Diabetes Consortium T2D Clinic Registry
Tamborlane WV, Chang P, Kollman C, Klingensmith GJ, Ruedy K, Gal RL, Van Name M, Bacha F, Willi S, Beck RW, Consortium F. Eligibility for clinical trials is limited for youth with type 2 diabetes: Insights from the Pediatric Diabetes Consortium T2D Clinic Registry. Pediatric Diabetes 2018, 19: 1379-1384. PMID: 30175440, DOI: 10.1111/pedi.12763.Peer-Reviewed Original ResearchConceptsType 2 diabetesT2D durationT2D patientsClinical trialsEligibility criteriaPlacebo-assigned subjectsPercentage of patientsCurrent clinical trialsRestrictive eligibility criteriaBaseline HbA1cHbA1c levelsClinical characteristicsClinic registryRegistry enrollmentInvestigational treatmentPatientsCurrent trialTrialsNew drugsMonthsHbA1cRatio of femaleDiabetesRegistryEnrollmentStressful Life Events in Young Adults With Type 1 Diabetes in the U.S. T1D Exchange Clinic Registry
Joiner KL, Holland ML, Grey M. Stressful Life Events in Young Adults With Type 1 Diabetes in the U.S. T1D Exchange Clinic Registry. Journal Of Nursing Scholarship 2018, 50: 676-686. PMID: 30246919, PMCID: PMC6788928, DOI: 10.1111/jnu.12428.Peer-Reviewed Original ResearchConceptsStressful life eventsT1D Exchange Clinic RegistryInsulin dosesGlycemic controlType 1 diabetesLife eventsClinic registryYoung adultsRecent stressful life eventsPoor glycemic controlMean A1C levelsTime of enrollmentSingle self-report itemDescriptive secondary analysisSelf-report itemsA1c levelsHemoglobin levelsMeasures of frequencyStressful eventsSecondary analysisMediation analysisDosesDichotomous variablesPositive approachEvent indexRisk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes (T1D)
MEHTA S, WU M, FOSTER N, POP-BUSUI R, KATZ M, CRANDALL J, BACHA F, NADEAU K, LIBMAN I, HIERS P, MIZOKAMI-STOUT K, DIMEGLIO L, SHERR J, PRATLEY R, AGARWAL S, SNELL-BERGEON J, CENGIZ E, POLSKY S, SHAH V. Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes (T1D). Diabetes 2018, 67 DOI: 10.2337/db18-15-lb.Peer-Reviewed Original ResearchCVD risk factorsIncident cardiovascular diseaseRisk factorsCardiovascular diseaseDiabetic nephropathyT1D Exchange Clinic RegistryTraditional CVD risk factorsEli LillyPediatric Diabetes ConsortiumBlood pressure medicationsIschemic heart diseaseImportant risk factorType 1 diabetesNon-fatal eventsNational InstituteYears of ageBoehringer Ingelheim PharmaceuticalsAdvisory PanelEisai Inc.MannKind CorporationDiabetes durationComposite outcomeHeart failureClinic registryContemporary cohortIncreased HbA1c Variability May Shorten Time to Microalbuminuria Development in Type 1 Diabetes (T1D)
CLEMENTS M, WU M, FOSTER N, LAFFEL L, SHAH V, VENDRAME F, KINGMAN R, ALONSO G, CARLSON A, DESALVO D, BUCKINGHAM B, SHERR J, BENJAMIN R, EYTH E, DUBOSE S. Increased HbA1c Variability May Shorten Time to Microalbuminuria Development in Type 1 Diabetes (T1D). Diabetes 2018, 67 DOI: 10.2337/db18-26-lb.Peer-Reviewed Original ResearchRisk of microalbuminuriaSD HbA1cDiabetes careT1D Exchange Clinic RegistryShorter diabetes durationSpeakers bureauType 1 diabetesAge of diagnosisEli LillyBoehringer Ingelheim PharmaceuticalsAdvisory PanelMannKind CorporationMicroalbuminuria developmentSanofi USDiabetes durationMean HbA1cT1D durationRenal diseaseClinic registryRegistry enrollmentClinic visit recordsT1D populationMedian numberMicroalbuminuriaDiabetes Institute
2017
Management and Family Burdens Endorsed by Parents of Youth <7 Years Old With Type 1 Diabetes
Harrington KR, Boyle CT, Miller KM, Hilliard ME, Anderson BJ, Van Name M, DiMeglio LA, Laffel LM. Management and Family Burdens Endorsed by Parents of Youth <7 Years Old With Type 1 Diabetes. Journal Of Diabetes Science And Technology 2017, 11: 980-987. PMID: 28770627, PMCID: PMC5951003, DOI: 10.1177/1932296817721938.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetes managementT1D Exchange Clinic RegistryDuration of diabetesMean hemoglobin A1cFamily impact scoresLow blood sugarQuality of sleepYoung childrenMedical record informationClinical characteristicsHemoglobin A1cSerious complicationsBlood sugarClinic registryMean ageFamily burdenSubstantial burdenParental burdenDiabetesAge groupsInsulin pumpType 1Parents of youthChildren's diabetes managementCorrelates of overweight and obesity in 5529 adolescents with type 1 diabetes: The T1D Exchange Clinic Registry
Minges KE, Whittemore R, Weinzimer SA, Irwin ML, Redeker NS, Grey M. Correlates of overweight and obesity in 5529 adolescents with type 1 diabetes: The T1D Exchange Clinic Registry. Diabetes Research And Clinical Practice 2017, 126: 68-78. PMID: 28214669, PMCID: PMC5401652, DOI: 10.1016/j.diabres.2017.01.012.Peer-Reviewed Original ResearchConceptsT1D Exchange Clinic RegistryType 1 diabetesRace/ethnicityClinic registryWeight statusHigher oddsHispanic/Latino race/ethnicityLatino race/ethnicityOverweight/obesityPrevalence of overweightCorrelates of overweightAllied healthcare providersLogistic regression analysisDiverse race/ethnicityMultinomial logistic regression analysisSelf-management factorsAnnual household incomeObesity preventionFemale genderObesityOverweightHealthcare providersOlder ageT1DLonger duration
2016
Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry
Fox LA, Mubasher M, Wolfsdorf JI, Buckingham BA, Peters AL, Tamborlane WV, Schatz DA, Maahs DM, Miller KM, Beck RW, Network F. Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry. Journal Of Diabetes 2016, 8: 834-838. PMID: 26663683, DOI: 10.1111/1753-0407.12363.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic ketoacidosisT1D Exchange Clinic RegistryInsulin pump therapyT1D Exchange RegistryContinuous glucose monitoringAcute complicationsGlycemic controlSevere hypoglycemiaClinic registryPump therapyPresent studyDiabetes managementT1D.T1DStudy participantsGlucose monitoringLinear mixed modelsDiabetesRegistryCharacteristics of youthChildrenAdolescentsMixed modelsStatistical comparison
2015
Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry
Clements MA, Foster NC, Maahs DM, Schatz DA, Olson BA, Tsalikian E, Lee JM, Burt‐Solorzano C, Tamborlane WV, Chen V, Miller KM, Beck RW, Network F. Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry. Pediatric Diabetes 2015, 17: 327-336. PMID: 26153338, DOI: 10.1111/pedi.12295.Peer-Reviewed Original ResearchConceptsGlycemic controlT1D Exchange Clinic RegistryEarly adulthoodDiabetes-related complicationsInsulin pump useHealth insuranceHemoglobin A1c changeType 1 diabetesAge 16Age of onsetAge 10 yrYoung adult cohortRace/ethnicityA1C changePatients 8Retrospective cohortClinical factorsClinic registryGlucose controlMedical recordsLongitudinal riskPump useAdult cohortAdolescent cohortCohortCurrent State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry
Miller KM, Foster NC, Beck RW, Bergenstal RM, DuBose SN, DiMeglio LA, Maahs DM, Tamborlane WV. Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry. Diabetes Care 2015, 38: 971-978. PMID: 25998289, DOI: 10.2337/dc15-0078.Peer-Reviewed Original ResearchConceptsYears of ageType 1 diabetesT1D Exchange Clinic RegistryContinuous glucose monitoringDiabetic ketoacidosisSevere hypoglycemiaClinic registryMetabolic controlOutcome of treatmentOptimal metabolic controlRegistry findingsAdvanced diabetes technologiesAverage HbA1cMean hemoglobinYounger patientsCommon complicationCurrent treatmentNew therapiesAge 30HbA1cType 1DiabetesGlucose monitoringDiabetes technologyAgePresentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium
Klingensmith GJ, Connor CG, Ruedy KJ, Beck RW, Kollman C, Haro H, Wood JR, Lee JM, Willi SM, Cengiz E, Tamborlane WV, Consortium F. Presentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium. Pediatric Diabetes 2015, 17: 266-273. PMID: 25951940, DOI: 10.1111/pedi.12281.Peer-Reviewed Original ResearchConceptsHyperglycemic hyperosmolar stateType 2 diabetesDiabetic ketoacidosisMedian body mass index (BMI) z-scoreBody mass index z-scorePediatric Diabetes ConsortiumPediatric diabetes centersTime of diagnosisIndex z-scoreSymptoms of diabetesHigh-risk childrenYr of ageCombination of insulinT2D participantsLifestyle modificationHyperosmolar stateLaboratory characteristicsClinical presentationDiabetes CenterInitial treatmentClinic registryMean ageFamily historyPediatric diseasesDiabetesC‐peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry
Gregg B, Connor CG, Cheng P, Ruedy KJ, Beck RW, Kollman C, Schatz D, Cengiz E, Tamborlane WV, Klingensmith GJ, Lee JM, Consortium F. C‐peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry. Pediatric Diabetes 2015, 17: 274-280. PMID: 25940861, DOI: 10.1111/pedi.12280.Peer-Reviewed Original ResearchConceptsC-peptide levelsC-peptide measurementsLower body mass indexPediatric type 2 diabetesInsulin-treated patientsEndogenous insulin secretionPediatric diabetes centersC-peptide valuesBody mass indexType 2 diabetesT2D durationInsulin therapyClinical factorsDiabetes CenterClinic registryMass indexC-peptideInsulin secretionInsulin treatmentLarge cohortT2DMetabolic controlType 2Biologic dataRegistryRacial-Ethnic Disparities in Management and Outcomes Among Children With Type 1 Diabetes
Willi SM, Miller KM, DiMeglio LA, Klingensmith GJ, Simmons JH, Tamborlane WV, Nadeau KJ, Kittelsrud JM, Huckfeldt P, Beck RW, Lipman TH. Racial-Ethnic Disparities in Management and Outcomes Among Children With Type 1 Diabetes. 2015, 135: 424-434. PMID: 25687140, PMCID: PMC4533245, DOI: 10.1542/peds.2014-1774.Peer-Reviewed Original ResearchConceptsHispanic participantsEthnic disparitiesSocioeconomic statusDiabetic ketoacidosisHemoglobin A1cT1D Exchange Clinic RegistryMean hemoglobin A1cLarge pediatric cohortOptimal glycemic controlSevere hypoglycemic eventsBlack participantsType 1 diabetesMore Black participantsNon-Hispanic blacksGlycemic controlSevere hypoglycemiaClinic registryClinical outcomesPediatric cohortHypoglycemic eventsDiabetes outcomesTreatment outcomesTherapeutic modalitiesDiabetes managementDiabetes treatment
2014
Therapeutic inertia: underdiagnosed and undertreated hypertension in children participating in the T1D Exchange Clinic Registry
Nambam B, DuBose SN, Nathan BM, Beck RW, Maahs DM, Wadwa RP, Tamborlane WV, Foster NC, Miller KM, Haller MJ, Network F. Therapeutic inertia: underdiagnosed and undertreated hypertension in children participating in the T1D Exchange Clinic Registry. Pediatric Diabetes 2014, 17: 15-20. PMID: 25330905, DOI: 10.1111/pedi.12231.Peer-Reviewed Original ResearchConceptsType 1 diabetesT1D Exchange Clinic RegistryElevated blood pressureBlood pressureClinic registryACE-I therapyReceptor blocker therapyGoal blood pressureDiagnosis of hypertensionPediatric diabetes clinicBlocker therapyBP goalHypertensive childrenUndertreated hypertensionARB therapyAggressive managementCardiovascular riskDiabetes clinicHigher BMIMedical recordsHypertensionReceptor inhibitorsDiabetesTherapyVisitsInsulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy
Blackman SM, Raghinaru D, Adi S, Simmons JH, Ebner‐Lyon L, Chase HP, Tamborlane WV, Schatz DA, Block JM, Litton JC, Raman V, Foster NC, Kollman CR, DuBose SN, Miller KM, Beck RW, DiMeglio LA. Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy. Pediatric Diabetes 2014, 15: 564-572. PMID: 24494980, DOI: 10.1111/pedi.12121.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionT1D Exchange Clinic RegistryCross-sectional studyInjection usersClinic registryInitiation of CSIIUse of CSIIInsulin pumpLower hemoglobin A1c levelsDiabetic ketoacidosis eventsHemoglobin A1c levelsSevere hypoglycemia eventsSubcutaneous insulin infusionRetrospective longitudinal studyType 1 diabetesRisk of DKALongitudinal studyYounger age groupsYoung childrenRace/ethnicityKetoacidosis eventsAnnual household incomeT1D durationA1c levelsHemoglobin A1c
2013
Factors Associated With Microalbuminuria in 7,549 Children and Adolescents With Type 1 Diabetes in the T1D Exchange Clinic Registry
Daniels M, DuBose SN, Maahs DM, Beck RW, Fox LA, Gubitosi-Klug R, Laffel LM, Miller KM, Speer H, Tamborlane WV, Tansey MJ. Factors Associated With Microalbuminuria in 7,549 Children and Adolescents With Type 1 Diabetes in the T1D Exchange Clinic Registry. Diabetes Care 2013, 36: 2639-2645. PMID: 23610082, PMCID: PMC3747908, DOI: 10.2337/dc12-2192.Peer-Reviewed Original ResearchConceptsT1D Exchange Clinic RegistryAngiotensin receptor blockersType 1 diabetesMA diagnosisDiabetes durationBlood pressureACE inhibitorsClinic registryACEI/ARB treatmentHigher diastolic blood pressureOlder ageRisk of nephropathyLonger diabetes durationDiastolic blood pressureYears of ageBP controlGood glycemicARB treatmentReceptor blockersCreatinine ratioNonmodifiable factorsUrinary albuminHemoglobin levelsFemale sexCurrent treatmentChallenges and Future Directions of the T1D Exchange Clinic Network and Registry
Miller KM, Xing D, Tamborlane WV, Bergenstal RM, Beck RW. Challenges and Future Directions of the T1D Exchange Clinic Network and Registry. Journal Of Diabetes Science And Technology 2013, 7: 963-969. PMID: 23911177, PMCID: PMC3879760, DOI: 10.1177/193229681300700418.Peer-Reviewed Original ResearchConceptsT1D Exchange Clinic NetworkClinic registryClinic networkT1D Exchange Clinic RegistryType 1 diabetes mellitusPublic health issueElectronic health recordsDiabetes historyDiabetes mellitusDiabetes CenterMedical recordsInsulin administrationMedical conditionsWide age rangeWeb-based questionnaireRegistryAutoimmune T1DMHealth issuesHealth recordsAge rangeData extractionParticipant completionT1DMClinicLaboratory results
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