2025
Patterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsy
2022
Subtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study
Lerch JM, Pai RK, Brown I, Gill AJ, Jain D, Kővári B, Kushima R, Sheahan K, Slavik T, Srivastava A, Lauwers GY, Langner C. Subtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study. Pathology 2022, 54: 262-268. PMID: 35221041, DOI: 10.1016/j.pathol.2021.12.288.Peer-Reviewed Original ResearchConceptsGastric intestinal metaplasiaChronic atrophic gastritisAmerican Gastroenterological AssociationAtrophic gastritisIntestinal metaplasiaConsensus diagnosisInterobserver variabilityCurrent practice guidelinesExpert pathologistsSubstantial overall agreementHigh interobserver agreementHistological diagnosisGastrointestinal endoscopyGastroenterological AssociationPractice guidelinesGastric cancerBiopsy piecesMucosal surfacesClinical decisionLevel of agreementInterobserver agreementInterobserver variability studyEuropean SocietyPredominant patternKappa statistics
2021
Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis
Lerch JM, Pai RK, Brown I, Gill AJ, Jain D, Kővári B, Kushima R, Sheahan K, Slavik T, Srivastava A, Lauwers GY, Langner C. Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis. Virchows Archiv 2021, 480: 1277-1281. PMID: 34904185, PMCID: PMC9184363, DOI: 10.1007/s00428-021-03245-9.Peer-Reviewed Original ResearchConceptsGastric intestinal metaplasiaChronic atrophic gastritisIntraclass correlation coefficientInterobserver agreementAtrophic gastritisIntestinal metaplasiaExtensive gastric intestinal metaplasiaAlcian blue-periodic acid SchiffExpert gastrointestinal pathologistsHigh interobserver agreementLow diagnostic accuracyMetaplastic epitheliumAntrum biopsiesGastrointestinal pathologistsGastric cancerDiagnostic accuracyAcid-SchiffAB-PASExpert pathologistsSpearman correlationGastritisMetaplasiaPatientsPathologistsCharacterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma
Saulino D, Chen R, Wang K, Shen M, Zhang X, Westerhoff M, Cheng J, Lin J, Zhang X, Feely M, Liu X. Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma. Gastroenterology Research 2021, 14: 13-20. PMID: 33737995, PMCID: PMC7935615, DOI: 10.14740/gr1359.Peer-Reviewed Original ResearchChronic atrophic gastritisChronic gastritisLS patientsGastric cancerIntestinal metaplasiaGastric adenocarcinomaNegative gastritisAtrophic gastritisIntestinal typeFamily historyEnterochromaffin-like cell hyperplasiaSignet ring cell carcinomaPyloric gland metaplasiaMixed type carcinomaLynch syndrome patientsGastric cancer casesPersonal cancer historyNon-neoplastic gastric mucosaBackground ChronicIntestinal metaplasia-dysplasiaEndoscopic resectionMedical chartsClinical featuresHistologic typeBody mucosa
2010
Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals
Lochhead P, Frank B, Hold GL, Rabkin CS, Ng MT, Vaughan TL, Risch HA, Gammon MD, Lissowska J, Weck MN, Raum E, Müller H, Illig T, Klopp N, Dawson A, McColl KE, Brenner H, Chow W, El–Omar E. Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals. Gastroenterology 2010, 140: 435-441. PMID: 21070776, PMCID: PMC3031760, DOI: 10.1053/j.gastro.2010.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntigens, NeoplasmCarcinoma, Squamous CellCase-Control StudiesEsophageal NeoplasmsFemaleGastritis, AtrophicGastrointestinal NeoplasmsGenetic Predisposition to DiseaseGPI-Linked ProteinsHelicobacter InfectionsHelicobacter pyloriHumansMaleNeoplasm ProteinsPolymorphism, Single NucleotideRiskWhite PeopleConceptsChronic atrophic gastritisNoncardia gastric cancerUpper gastrointestinal cancerGastric cancer casesProstate stem cell antigen (PSCA) geneCancer casesGastric cancerAtrophic gastritisGastrointestinal cancerRs2294008 polymorphismWhite individualsRisk allelesHelicobacter pylori-infected subjectsPylori-infected subjectsPopulation-based studySquamous cell carcinomaGastric cancer patientsGastric cardia cancerCase-control studyEsophageal cancer casesDiffuse histologic typeAntigen geneProximal cancersGastric atrophyHistologic type
2003
Gastric Atrophy, Metaplasia, and Dysplasia
Kapadia CR. Gastric Atrophy, Metaplasia, and Dysplasia. Journal Of Clinical Gastroenterology 2003, 36: s29-s36. PMID: 12702963, DOI: 10.1097/00004836-200305001-00006.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisIntestinal metaplasiaAtrophic gastritisCobalamin deficiencyGastric atrophyPernicious anemiaPylori infectionDysplastic epitheliumH. pyloriFamilial Peutz-Jeghers syndromeChronic Helicobacter pylori infectionH. pylori-related gastritisSerum cobalamin levelsH. pylori infectionHelicobacter pylori infectionHigh-grade dysplasiaEarly gastric cancerExtent of atrophyRecent consensus conferenceFamilial adenomatous polyposis syndromeGastric adenomatous polypsAdenomatous polyposis syndromePeutz-Jeghers syndromeAutoimmune gastritisGastric remnant
1999
Helicobacter pylori infection on the risk of stomach cancer and chronic atrophic gastritis.
Zhang Z, Kurtz R, Klimstra D, Yu G, Sun M, Harlap S, Marshall J. Helicobacter pylori infection on the risk of stomach cancer and chronic atrophic gastritis. Cancer Epidemiology 1999, 23: 357-67. PMID: 10468887, DOI: 10.1046/j.1525-1500.1999.99041.x.Peer-Reviewed Original ResearchConceptsRisk of stomach cancerStomach cancerChronic atrophic gastritisH. pylori infectionAssociated with risk of stomach cancerMemorial Sloan-Kettering Cancer CenterOdds ratioPrevention of stomach cancerPack-years of smokingHelicobacter pylori infectionDevelopment of stomach cancerDevelopment of chronic atrophic gastritisAssociated with riskPotential confounding variablesBody mass indexHigh-risk populationAtrophic gastritisPylori infectionGastric cancerNormal controlsAssociated with H. pylori infectionHistory questionnairePack-yearsAssociated with gastric adenocarcinomaAlcohol drinking
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