2021
Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma
Saulino D, Chen R, Wang K, Shen M, Zhang X, Westerhoff M, Cheng J, Lin J, Zhang X, Feely M, Liu X. Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma. Gastroenterology Research 2021, 14: 13-20. PMID: 33737995, PMCID: PMC7935615, DOI: 10.14740/gr1359.Peer-Reviewed Original ResearchChronic atrophic gastritisChronic gastritisLS patientsGastric cancerIntestinal metaplasiaGastric adenocarcinomaNegative gastritisAtrophic gastritisIntestinal typeFamily historyEnterochromaffin-like cell hyperplasiaSignet ring cell carcinomaPyloric gland metaplasiaMixed type carcinomaLynch syndrome patientsGastric cancer casesPersonal cancer historyNon-neoplastic gastric mucosaBackground ChronicIntestinal metaplasia-dysplasiaEndoscopic resectionMedical chartsClinical featuresHistologic typeBody mucosa
2020
Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status
Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano A, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG. Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status. Journal Of The American College Of Surgeons 2020, 230: 669-675. PMID: 32007537, PMCID: PMC7104918, DOI: 10.1016/j.jamcollsurg.2020.01.005.Peer-Reviewed Original ResearchConceptsLP/P variantsMetachronous colorectal cancerColorectal cancerTotal colectomySegmental resectionSegmental colectomyMMR genesLS patientsLynch syndromeMetachronous colorectal neoplasmsMismatch repair gene statusPrimary end pointRetrospective cohort studyMMR germline mutationsLynch syndrome patientsQuality of lifeMismatch repair genesCRC overallCRC ratesEarly colectomyIndex resectionMedian followMSH2 carriersCRC incidenceCohort studyFrequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients
Wong S, Hui P, Buza N. Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients. Modern Pathology 2020, 33: 1172-1181. PMID: 31932681, DOI: 10.1038/s41379-020-0455-x.Peer-Reviewed Original ResearchConceptsLynch syndrome patientsLynch syndromeMMR protein expressionSporadic endometrial carcinomasSyndrome patientsEndometrial cancerEndometrial glandsEndometrial carcinomaProtein expressionLynch syndrome-associated endometrial cancerGermline mutationsMismatch repair protein expressionMMR protein immunohistochemistryEndometrial cancer patientsNonneoplastic endometriumBenign endometrial tissuesMicrosatellite instability testingMMR protein lossGermline mutation analysisDNA mismatch repair genesRepair protein expressionMismatch repair genesBackground endometriumMMR immunohistochemistryProphylactic hysterectomy
2013
Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry
Shia J, Holck S, DePetris G, Greenson J, Klimstra D. Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry. Familial Cancer 2013, 12: 241-260. PMID: 23435936, DOI: 10.1007/s10689-013-9612-4.Peer-Reviewed Original Research
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