A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures
Rifkin R, Wu X, Pereira B, Gill B, Merricks E, Michalak A, Goldberg A, Humala N, Dovas A, Rai G, McKhann G, Slesinger P, Canoll P, Schevon C. A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures. Neuropharmacology 2024, 265: 110259. PMID: 39662702, PMCID: PMC11726401, DOI: 10.1016/j.neuropharm.2024.110259.Peer-Reviewed Original ResearchConceptsMouse modelInwardly-rectifying potassium channelRegulation of neuronal excitabilityMouse models of tumorsSeizure-like activityGIRK channelsNeuronal excitabilityModels of tumorsPeritumoral regionEpileptiform activityTumor-associatedTumor progressionAntiseizure medicationsPotassium channelsChronic epilepsyFocal seizuresAnimal modelsTumorBrain tumorsGIRKInadequate treatmentGlioma cellsMiceSeizuresChemoconvulsant models
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