2014
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans
Repunte-Canonigo V, Herman MA, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP. Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans. Biological Psychiatry 2014, 77: 870-879. PMID: 25483400, PMCID: PMC4428692, DOI: 10.1016/j.biopsych.2014.07.031.Peer-Reviewed Original ResearchConceptsChronic intermittent ethanol vapor exposureGABA releaseWild-type miceGamma-aminobutyric acidAlcohol dependenceCentral amygdalaGamma-aminobutyric acid releaseIntermittent ethanol vapor exposureExcessive drinkingMouse central amygdalaEthanol vapor exposureHeterozygous null miceAlcohol dependence riskInduction of dependenceAlcohol drinkingAlcohol-related behaviorsDependent drinkingBinge drinkingTranslational investigationsNull miceCentral nucleusType 1 geneMiceAmygdalaAcid release
2009
Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice
Kinsler R, Taylor MM, Flores NM, Leffert JJ, Beech RD. Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice. Synapse 2009, 64: 169-171. PMID: 19852072, PMCID: PMC2789865, DOI: 10.1002/syn.20737.Peer-Reviewed Original ResearchConceptsAdult hippocampal neurogenesisTail suspension testDifferent rodent modelsHeterozygous knockout miceForkhead box protein G1Heterozygous null miceRole of Foxg1Phosphatidyl inositol 3 kinaseContextual fear learningMechanism of actionAntidepressant actionHippocampal neurogenesisNeurogenic propertiesSwim testMood disordersRodent modelsSuspension testAntidepressantsKnockout miceLittermate controlsBehavioral abnormalitiesNull miceNormal levelsFOXG1 geneAltered response
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply