2024
Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis
Dave J, Chakraborty R, Agyemang A, Ntokou A, Saito J, Ballabh P, Martin K, Greif D. Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis. Stroke 2024, 55: 2340-2352. PMID: 39129597, PMCID: PMC11347087, DOI: 10.1161/strokeaha.123.045248.Peer-Reviewed Original ResearchAngiopoietin-2Germinal matrix hemorrhage-intraventricular hemorrhagePerinatal lethalityEndothelial cell hyperproliferationEndothelial cellsBrain pericytesGenetic inhibitionVascular cellsBlood-brain barrier integrityBlood-brain barrier developmentBrain vascular cellsAbnormal vessel morphologyVessel morphologyProlonged survivalRegulating cross-talkMutant endothelial cellsHuman brain pericytesGerminal matrixCell hyperproliferationPhosphorylates Tie2Embryonic miceCellular sourceBarrier integrityGenetic ablationTherapeutic effectmTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis
Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan V, Su M, Murray K, Grutzendler J, Zhou J. mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. Circulation Research 2024, 135: e94-e113. PMID: 38957991, PMCID: PMC11293987, DOI: 10.1161/circresaha.123.324015.Peer-Reviewed Original ResearchCerebral vascular malformationsEndothelial progenitor cellsBlood-brain barrier integritySingle-cell RNA sequencing analysisDisruption of blood-brain barrier integrityBarrier integrityResident endothelial progenitor cellsRNA sequencing analysisTissue immunofluorescence analysisEndothelial cellsEPC clustersStem cell markersFocal neurological deficitsBrain's neurovascular unitMTOR signalingHuman CCM lesionsMTORC1 signalingBlood-brain barrierCapillary endothelial cellsCCM pathogenesisVascular malformationsLesion signaturesNeurological deficitsCell markersClonal expansion
2023
Novel hippocampal genes involved in enhanced susceptibility to chronic pain-induced behavioral emotionality
Garman A, Ash A, Kokkinos E, Nerland D, Winter L, Langreck C, Forgette M, Girgenti M, Banasr M, Duric V. Novel hippocampal genes involved in enhanced susceptibility to chronic pain-induced behavioral emotionality. European Journal Of Pharmacology 2023, 964: 176273. PMID: 38135263, DOI: 10.1016/j.ejphar.2023.176273.Peer-Reviewed Original ResearchBlood-brain barrier integrityChronic pain statesBehavioral emotionalityHippocampal genesPain statesGenome-wide RNA-seq analysisStress responseBarrier integrityCommon stress responseRNA-seq analysisAurora kinase BChronic inflammatory painDepressive-like behaviorChronic pain conditionsRodent stress modelsLimbic brain regionsTight junction proteinsBioinformatics analysisInflammatory painAstrocyte activationPain groupPain conditionsTranscriptomic profilesAltered moodKinase BPericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
Teske N, Dyckhoff-Shen S, Beckenbauer P, Bewersdorf J, Engelen-Lee J, Hammerschmidt S, Kälin R, Pfister H, Brouwer M, Klein M, Glass R, van de Beek D, Koedel U. Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function. Journal Of Neuroinflammation 2023, 20: 267. PMID: 37978545, PMCID: PMC10655320, DOI: 10.1186/s12974-023-02938-z.Peer-Reviewed Original ResearchConceptsModel of pneumococcal meningitisPneumococcal meningitisLeukocyte infiltrationAnimal model of pneumococcal meningitisPrevented blood-brain barrierToll-like receptor inhibitorsDegree of leukocyte infiltrationSerotypes of Streptococcus pneumoniaeUnfavorable disease courseBlood-brain barrier disruptionHuman pericytesExperimental pneumococcal meningitisBlood-brain barrier integrityRegulating leukocyte infiltrationBlood-brain barrier functionRegulation of cerebral blood flowAdult mouse modelInfection in vivoUpregulation of chemokine expressionIncreased cerebral edemaMaintenance of blood-brain barrier integrityBlood-brain barrierCerebral blood flowMouse meningitis modelIn vitro studies
2021
Imaging the transmembrane and transendothelial sodium gradients in gliomas
Khan MH, Walsh JJ, Mihailović JM, Mishra SK, Coman D, Hyder F. Imaging the transmembrane and transendothelial sodium gradients in gliomas. Scientific Reports 2021, 11: 6710. PMID: 33758290, PMCID: PMC7987982, DOI: 10.1038/s41598-021-85925-9.Peer-Reviewed Original Research
2019
Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
Farhadian SF, Mistry H, Kirchwey T, Chiarella J, Calvi R, Chintanaphol M, Patel P, Landry ML, Robertson K, Spudich SS. Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL. Open Forum Infectious Diseases 2019, 6: ofz528. PMID: 31893212, PMCID: PMC6934883, DOI: 10.1093/ofid/ofz528.Peer-Reviewed Original ResearchAntiretroviral therapyHIV RNACerebrospinal fluidBlood-brain barrier integrityCentral nervous system pathologyCNS immune activationCSF HIV RNANervous system pathologyCSF HIVCSF RNAImmune activationCNS injuryCopies/Neuropsychological testingSystem pathologyBarrier integrityCNS parametersHIVStandard assayExecutive functionRNAInjuryTherapySignificance of RNAPathologyThe impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes
Falcone JD, Sohal H, Kyriakides T, Bellamkonda RV. The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes. Journal Of Neural Engineering 2019, 16: 046005. PMID: 31048574, DOI: 10.1088/1741-2552/ab1ef9.Peer-Reviewed Original ResearchConceptsCCL2/CCR2 pathwayCCR2 pathwayBlood-brain barrier integrityIntracortical electrodesPro-inflammatory monocytesBlood-brain barrierBBB breachFunctional electrophysiologyChronic outcomesHistological outcomesWeek cohortCCR2 antagonistHistological effectsTreatment groupsElectrode implantationNeurodegenerative modelsBarrier integrityElectrophysiological recordingsNumber of neuronsWeeksHistologyLong-term recordingsBiological mechanismsNeural populationsElectrophysiology
2018
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.
Namioka T, Namioka A, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction. Journal Of Neurosurgery 2018, 131: 1289-1296. PMID: 30485210, DOI: 10.3171/2018.5.jns18140.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionCerebral infarctionIntravenous infusionMesenchymal stem cellsChronic phaseRat modelBone marrowBlood-brain barrier integrityCerebral artery occlusionVehicle-treated groupChronic cerebral infarctionPhase of strokeStem cellsAdult bone marrowArtery occlusionBBB leakageMotor recoveryFunctional recoveryIschemic volumeFunctional outcomeSystemic infusionBrain parenchymaFunctional improvementSystemic injectionClinical studies
2017
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolution
2013
CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis A Role in Immune Cells and Vascular Cells of the Blood–Brain Barrier
Flynn KM, Michaud M, Madri JA. CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis A Role in Immune Cells and Vascular Cells of the Blood–Brain Barrier. American Journal Of Pathology 2013, 182: 1322-1336. PMID: 23416161, PMCID: PMC3620422, DOI: 10.1016/j.ajpath.2013.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBone Marrow CellsCell AdhesionCell MovementCell PolarityChimeraEncephalomyelitis, Autoimmune, ExperimentalEndothelial CellsGene DeletionHyaluronan ReceptorsInflammationInflammation MediatorsMiceMice, Inbred C57BLMice, KnockoutPermeabilityProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaStromal CellsT-Lymphocytes, RegulatoryConceptsExperimental autoimmune encephalomyelitisBlood-brain barrierCD44-deficient miceCytokine productionT cellsCD44 deficiencyDisease severityBone marrow chimeric animalsMyelin oligodendrocyte glycoprotein peptideBlood-brain barrier integrityT helper 17 (Th17) cellsT cell-endothelial cell interactionsImmune cell numbersRegulatory T cellsCD4 T cellsHelper 17 cellsCD44 knockout miceProinflammatory cytokine productionWild-type miceCentral nervous systemGreater disease severityT cell differentiationAdhesion molecule CD44Type I expressionMultiple protective roles
2001
Management of Brain Edema Complicating Stroke
Rosand J, Schwamm L. Management of Brain Edema Complicating Stroke. Journal Of Intensive Care Medicine 2001, 16: 128-141. DOI: 10.1046/j.1525-1489.2001.00128.x.Peer-Reviewed Original ResearchCerebral blood flowSecondary brain injuryBrain edemaMagnetic resonance imagingBrain parenchymaVasogenic edemaBrain injuryBlood-brain barrier integrityGlobal cerebral blood flowIschemic brain swellingLocal tissue dysfunctionSerial Neurologic AssessmentIschemic brain edemaOnset of symptomsIntracranial blood volumeIschemic cell injuryResult of injurySpecific MRI sequencesAccumulation of fluidDiffusion-weighted imagingRheologic agentsNeurologic deteriorationBrain swellingDecompressive surgeryIschemic strokeManagement of Brain Edema Complicating Stroke
Rosand J, Schwamm L. Management of Brain Edema Complicating Stroke. Journal Of Intensive Care Medicine 2001, 16: 128-141. DOI: 10.1177/088506660101600303.Peer-Reviewed Original ResearchCerebral blood flowSecondary brain injuryBrain edemaMagnetic resonance imagingBrain parenchymaVasogenic edemaBrain injuryBlood-brain barrier integrityGlobal cerebral blood flowIschemic brain swellingLocal tissue dysfunctionSerial Neurologic AssessmentIschemic brain edemaOnset of symptomsIntracranial blood volumeIschemic cell injuryResult of injurySpecific MRI sequencesAccumulation of fluidDiffusion-weighted imagingRheologic agentsNeurologic deteriorationBrain swellingDecompressive surgeryIschemic stroke
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