2024
Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis
Holtgrewe L, Johnson A, Nyhan K, Boffa J, Shenoi S, Karat A, Davis J, Charalambous S. Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis. PLOS Global Public Health 2024, 4: e0003753. PMID: 39361564, PMCID: PMC11449336, DOI: 10.1371/journal.pgph.0003753.Peer-Reviewed Original ResearchLatent TB infection prevalenceLatent TB infectionUnderserved populationsTB prevalenceMeta-analysisSystematic reviewNational averagePrevalence of TB diseaseCalculate prevalence ratiosTB diseaseCase-finding strategiesPopulation of personsAssessed study qualityHigh TB prevalenceHigh-burden countriesBurden of tuberculosisTB interventionsPrevalence ratiosStudy qualityReduce tuberculosisHIV statusActive TB diseaseGeneral populationModerate heterogeneityTB incidenceCommunity-level variation in TB testing history in Blantyre, Malawi
Nightingale E, Feasey H, Khundi M, Soko R, Burke R, Nliwasa M, Twabi H, Mpunga J, Fielding K, MacPherson P, Corbett E. Community-level variation in TB testing history in Blantyre, Malawi. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 32-38. PMID: 38303035, DOI: 10.5588/ijtld.23.0213.Peer-Reviewed Original ResearchConceptsCluster-level variationsTB testCase-finding effortsCluster-level random interceptEver-testingHealth inequalitiesCommunity-level variationTB servicesTesting historyHIV statusSurvey participantsPoverty indicatorsRandom interceptAffluent householdsEquitable accessNeighborhood clustersDiagnostic servicesPoor communitiesBlantyre CityTB prevalenceSocio-economic driversBlantyrePovertyPrevalenceInequality
2023
Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics
Dodd P, Shaweno D, Ku C, Glaziou P, Pretorius C, Hayes R, MacPherson P, Cohen T, Ayles H. Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics. Nature Communications 2023, 14: 1639. PMID: 36964130, PMCID: PMC10037365, DOI: 10.1038/s41467-023-37314-1.Peer-Reviewed Original ResearchConceptsHigh HIV prevalence settingsEstimation of burdenHIV prevalence settingsGeneralized HIV epidemicsTB transmission modelAntiretroviral therapyTB infectionTB incidenceHIV prevalenceTB prevalencePrevalence settingsTB epidemicHIV epidemicHigh burdenBurden estimatesNotification dataAnnual riskSingle pathogenIntervention impactTherapy effectsTuberculosisPrevalenceEpidemicBurdenAfrican countries
2022
Neighbourhood prevalence-to-notification ratios for adult bacteriologically-confirmed tuberculosis reveals hotspots of underdiagnosis in Blantyre, Malawi
Khundi M, Carpenter JR, Corbett EL, Feasey HRA, Soko RN, Nliwasa M, Twabi H, Chiume L, Burke RM, Horton KC, Dodd PJ, Cohen T, MacPherson P. Neighbourhood prevalence-to-notification ratios for adult bacteriologically-confirmed tuberculosis reveals hotspots of underdiagnosis in Blantyre, Malawi. PLOS ONE 2022, 17: e0268749. PMID: 35605004, PMCID: PMC9126376, DOI: 10.1371/journal.pone.0268749.Peer-Reviewed Original ResearchConceptsCase notification ratesPrevalence surveyNotification ratioNeighbourhood prevalenceTB case notification ratesXpert MTB/RIFCase-finding interventionsTrue disease burdenChest X-ray screeningTB prevalence surveyTB surveillance systemMTB/RIFDiagnosis of tuberculosisSputum smear microscopyTB clinicTB patientsRespiratory infectionsTB prevalenceDisease burdenNotification ratesSmear microscopyX-ray screeningTuberculosisPrevalenceUrban tuberculosisSpatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making
de Villiers AK, Dye C, Yaesoubi R, Cohen T, Marx FM. Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making. Epidemics 2022, 38: 100540. PMID: 35093849, PMCID: PMC8983993, DOI: 10.1016/j.epidem.2022.100540.Peer-Reviewed Original ResearchConceptsHigh-burden settingsTB casesTB prevalenceChest radiographyAdditional TB casesCase-finding yieldTB prevalence estimatesHigh-burden populationsCommunity-randomized trialNumber of screeningsTB controlXpert UltraScreening roundNotification ratesPrevalence estimatesTuberculosisPrevalenceDigital chest radiographyScreeningTrialsInterventionRadiography
2019
Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: Cost-effectiveness analysis for India’s public sector
Lee DJ, Kumarasamy N, Resch SC, Sivaramakrishnan GN, Mayer KH, Tripathy S, Paltiel AD, Freedberg KA, Reddy KP. Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: Cost-effectiveness analysis for India’s public sector. PLOS ONE 2019, 14: e0218890. PMID: 31265470, PMCID: PMC6605662, DOI: 10.1371/journal.pone.0218890.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioLife expectancySmear microscopyXpert MTB/RIFHIV-negative adultsPeripheral healthcare settingsMTB/RIFPrimary healthcare facilitiesSputum smear microscopyCost-effectiveness ratioCost-effectiveness analysisPresumptive tuberculosisTB diagnosisTB prevalenceTruenatMicroscopy centresXpertBudget impactRifampicin resistanceDiagnostic strategiesTuberculosisTB detectionHealthcare settingsDiagnostic sensitivityNovel molecular assay
2018
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott’s Disease
Robledo-Gil T, Harada K, Ikuta I, Villanueva M. Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott’s Disease. American Journal Of Case Reports 2018, 19: 699-704. PMID: 29907737, PMCID: PMC6034555, DOI: 10.12659/ajcr.909194.Peer-Reviewed Case Reports and Technical NotesConceptsAppropriate anti-tuberculosis therapyHIV-seronegative patientsLow TB prevalenceParadoxical reactionTB prevalencePott's diseaseHIV-seronegative individualsTimely clinical managementFull neurologic recoveryAnti-tuberculosis therapyAppropriate diagnostic approachATT regimenRadiological worseningTB meningitisTransient diplopiaNeurologic recoveryClinical improvementHIV-seropositiveTuberculous meningitisRadiologic changesSuch patientsBack painNew lesionsClinical findingsClinical symptoms
2016
High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions
Marx FM, Floyd S, Ayles H, Godfrey-Faussett P, Beyers N, Cohen T. High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions. European Respiratory Journal 2016, 48: 1227-1230. PMID: 27390274, PMCID: PMC5512114, DOI: 10.1183/13993003.00716-2016.Peer-Reviewed Original ResearchConceptsHigh-burden settingsHigh TB prevalenceRecurrent tuberculosisExogenous reinfectionPrevalent tuberculosisTB prevalenceSuccessful treatmentHigh burdenImportant underlying mechanismHigh riskHigh incidenceControl interventionsTargeted interventionsTuberculosisUnderlying mechanismOne-thirdInterventionBurdenCape TownIndividualsReinfectionPrevalenceIncidenceDiseaseSetting
2015
Evaluating the potential impact of enhancing HIV treatment and tuberculosis control programmes on the burden of tuberculosis
Chindelevitch L, Menzies NA, Pretorius C, Stover J, Salomon JA, Cohen T. Evaluating the potential impact of enhancing HIV treatment and tuberculosis control programmes on the burden of tuberculosis. Journal Of The Royal Society Interface 2015, 12: 20150146. PMID: 25878131, PMCID: PMC4424692, DOI: 10.1098/rsif.2015.0146.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyTB incidenceTB burdenBurden of tuberculosisTuberculosis Control ProgrammePotential epidemiological impactART eligibilityMortality benefitTB programsHIV treatmentTB prevalenceTuberculosis incidenceEpidemiological impactART useProgram improvementHIVTreatment effectivenessIncidenceMortalityGreater reductionBurdenTBSaharan AfricaControl programsEligibilityPrevalence and correlates of latent tuberculosis infection among employees of a high security prison in Malaysia
Al-Darraji HA, Tan C, Kamarulzaman A, Altice FL. Prevalence and correlates of latent tuberculosis infection among employees of a high security prison in Malaysia. Occupational And Environmental Medicine 2015, 72: 442. PMID: 25794506, PMCID: PMC4625842, DOI: 10.1136/oemed-2014-102695.Peer-Reviewed Original ResearchConceptsTST positivityTuberculin skin test (TST) positivityMalaysia's largest prisonLatent tuberculosis infectionCurrent tobacco smokingSkin test positivityTB control programsLogistic regression analysisLargest prisonInduration sizeTobacco smokingTuberculosis infectionTB prevalenceTB transmissionTest positivitySociodemographic dataTB problemPrevalenceYoung menComplete dataPositivityRegression analysisStructured questionnaireCorrectional systemPrison employees
2014
Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania
Gupta A, Mbwambo J, Mteza I, Shenoi S, Lambdin B, Nyandindi C, Doula BI, Mfaume S, Bruce RD. Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 793-798. PMID: 24902554, PMCID: PMC4506927, DOI: 10.5588/ijtld.13.0208.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationActive casesTB prevalenceCase findingMore TB symptomsNew TB casesSymptom-based questionnaireActive case findingPopulation of PWIDTuberculosis case detectionHigh occupational riskTB symptomsTB casesMedian ageTB controlMethadone treatmentHuman immunodeficiencyMethadone clientsCase detectionOccupational riskPrevalenceHealth OrganizationDar es SalaamPWIDDrugs
2013
‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis
Shenoi SV, Brooks RP, Catterick K, Moll AP, Friedland GH. ‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis. Public Health Action 2013, 3: 46-50. PMID: 25392815, PMCID: PMC4226409, DOI: 10.5588/pha.12.0056.Peer-Reviewed Original ResearchGeneral medical clinicDrug-resistant tuberculosisMedical clinicsClinic attendeesTB suspectsHuman immunodeficiency virus (HIV) patientsHigh HIV prevalence settingsZiehl-NeelsenProportion of patientsHIV prevalence settingsCulture-positive casesResource-limited settingsWorld Health OrganizationTB screeningVirus patientsHigh HIVResistant tuberculosisPatient populationTB prevalencePrevalence settingsReferral laboratoryTuberculosisDrug resistancePatientsClinic
2011
Diabetes mellitus and tuberculosis in countries with high tuberculosis burdens: individual risks and social determinants
Goldhaber-Fiebert JD, Jeon CY, Cohen T, Murray MB. Diabetes mellitus and tuberculosis in countries with high tuberculosis burdens: individual risks and social determinants. International Journal Of Epidemiology 2011, 40: 417-428. PMID: 21252210, PMCID: PMC3621385, DOI: 10.1093/ije/dyq238.Peer-Reviewed Original ResearchConceptsDiabetes prevalenceTB prevalenceSocial determinantsHigh TB burdenBody mass indexHigh tuberculosis burdenType 2 diabetesIndividual-level risk factorsWorld Health SurveyTB burdenDiabetes mellitusPrevalent tuberculosisTuberculosis burdenMass indexIndividual-level riskBody of evidenceRisk factorsHealth SurveyDiabetesTuberculosisPrevalenceLow-income countriesHealth policyIndividual riskPopulation health
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