2022
Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining
Mortlock RD, Wu C, Potter EL, Abraham DM, Allan DSJ, Hong SG, Roederer M, Dunbar CE. Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining. Frontiers In Immunology 2022, 12: 772332. PMID: 35095846, PMCID: PMC8790741, DOI: 10.3389/fimmu.2021.772332.Peer-Reviewed Original ResearchConceptsNatural killer cellsNK cellsKiller cellsPeripheral bloodIntravascular stainingHuman NK cell biologyRhesus macaquesNK cell subsetsNK cell biologyTissue distributionNon-lymphoid tissuesNK compartmentLymph nodesCell subsetsAnimal modelsRM tissuesCD16Perivascular compartmentTrafficking patternsTissueBloodHigher proportionStainingCellsDifferent subsets
2020
Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2
Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 nucleocapsid proteinPerivascular lymphocytesImmunohistochemical stainingCOVID-19 pandemicSARS-CoV-2 immunohistochemistryNucleocapsid proteinSARS-CoV-2Inflammatory lesionsHistopathologic findingsIntravascular occlusionMicroscopic findingsPerniosisIntravascular materialLymphocytesLesionsPatientsStainingPandemicSuch casesCuffingHistopathologyCasesImmunohistochemistryFindingsProtein
2017
Basal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma
Panse G, McNiff JM, Ko CJ. Basal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma. Journal Of Cutaneous Pathology 2017, 44: 553-556. PMID: 28403527, DOI: 10.1111/cup.12950.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaBasal cell carcinomaCases of BCCCell carcinomaCD56 expressionCases of MCCHistopathological examinationNeuroendocrine differentiationNeuroendocrine tumorsDifferential diagnosisCD56Sensitive markerUseful markerCarcinomaPatchy expressionTumorsDifficult casesMarkersStainingExpression
2016
Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol
Gul Z, Demircan C, Bagdas D, Buyukuysal R. Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol. Neurochemical Research 2016, 41: 2075-2085. PMID: 27161374, DOI: 10.1007/s11064-016-1919-8.Peer-Reviewed Original ResearchConceptsOxidative stress parametersCortical slicesRat brain slicesRat cortical slicesStress parametersChlorogenic acidChloride stainingProtective effectBrain slicesOxidative stressQuinic acidResveratrolNatural phenolic compoundsMain metaboliteMalondialdehydeCaffeic acidROS levelsIncubation mediumPhenolic compoundsAlterationsIC50 valuesPresent studyStainingΜM H2O2Oxygen speciesCorrection: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, Titz B, Graeber T, Park E, Tan Y, Satterthwaite A, Paietta E, Hunger S, Willman C, Melnick A, Loh M, Jung J, Coligan J, Bolland S, Mak T, Limnander A, Jumaa H, Reth M, Weiss A, Lowell C, Müschen M. Correction: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 2016, 534: 138-138. PMID: 26958840, DOI: 10.1038/nature16997.Peer-Reviewed Original Research
2014
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma
Alomari AK, Glusac EJ, McNiff JM. p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal Of Cutaneous Pathology 2014, 41: 839-845. PMID: 25263848, DOI: 10.1111/cup.12388.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAtypical fibroxanthomaCell carcinomaNon-cutaneous squamous-cell carcinomaNuclear stainingNon-squamous tumorsGiant cell tumorCutaneous leiomyosarcomaExclusive nuclear stainingCell tumorsDiagnostic challengeCytokeratin MNF116Focal stainingMNF116Tumor cytoplasmLeiomyosarcomaDiagnostic accuracyControl casesSoft tissueSpecific markersP40StainingCarcinomaP63TumorsChapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo
Scheller EL, Troiano N, VanHoutan JN, Bouxsein MA, Fretz JA, Xi Y, Nelson T, Katz G, Berry R, Church CD, Doucette CR, Rodeheffer MS, MacDougald OA, Rosen CJ, Horowitz MC. Chapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo. Methods In Enzymology 2014, 537: 123-139. PMID: 24480344, PMCID: PMC4097010, DOI: 10.1016/b978-0-12-411619-1.00007-0.Peer-Reviewed Original ResearchConceptsStromal vascular fractionBone marrowAdipose tissueBone marrow adipose tissueWhite adipose tissue depotsMicrocomputerized tomographyAdipose tissue depotsMarrow recoveryDrug treatmentMedullary canalTissue depotsMetabolic diseasesVascular fractionStromal cellsMarrow fatEndothelial cellsAdipocyte progenitorsMature adipocytesLong bonesMAT volumeAdipocytesStainingOsmium tetroxide stainingHistochemical stainingConventional quantitation
2013
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology 2013, 27: 62-72. PMID: 23807780, DOI: 10.1038/modpathol.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBiomarkers, TumorBiopsyC-Reactive ProteinChildChild, PreschoolDiagnosis, DifferentialDiagnostic ErrorsFemaleFocal Nodular HyperplasiaGlutamate-Ammonia LigaseHumansImmunohistochemistryInflammation MediatorsLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsSerum Amyloid A ProteinYoung AdultConceptsSerum amyloid-associated proteinFocal nodular hyperplasiaAmyloid-associated proteinsInflammatory hepatocellular adenomaNodular hyperplasiaHepatocellular adenomaStaining patternDuctular reactionFibrous stromaFocal nodular hyperplasia casesMap-like patternOverlapping histological featuresGlutamine synthetase stainingHistological featuresProtein immunohistochemistryHyperplasia casesIndeterminate lesionsPositive stainingHyperplasiaDiagnostic utilityAdenomasBlood vesselsFrequent overlapStainingDiagnostic errors
2012
Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy
Yeung JT, Hamilton RL, Okada H, Jakacki RI, Pollack IF. Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy. Journal Of Neuro-Oncology 2012, 111: 103-111. PMID: 23179498, PMCID: PMC3546121, DOI: 10.1007/s11060-012-0998-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntigens, NeoplasmBrainBrain NeoplasmsCancer VaccinesChildChild, PreschoolEpendymomaFemaleGene Expression Regulation, NeoplasticHistocompatibility Antigens Class IHumansInfantInhibitor of Apoptosis ProteinsInterleukin-13 Receptor alpha1 SubunitMaleMiddle AgedReceptor, EphA2SurvivinWT1 ProteinsConceptsTumor-associated antigensMore tumor-associated antigensIL-13Rα2Positive stainingAdult ependymomasMultiple peptides vaccineNormal brain tissueGlioma vaccinesImmunotherapy approachesVaccine therapyPediatric casesAdult casesTumor recurrenceClinical trialsPeptide vaccinePediatric ependymomaNormal brainEpendymomaBrain tissuePediatric gliomasTumor 1SurvivinStainingEphA2Vaccine
2009
Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge
Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge. Endocrinology 2009, 150: 2783-2790. PMID: 19282389, DOI: 10.1210/en.2008-0927.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstradiolEstrogensEstrous CycleFemaleGonadotropinsMiceMice, Inbred C57BLMidline Thalamic NucleiModels, AnimalNeural Cell Adhesion Molecule L1Neural Cell Adhesion MoleculesNeuronal PlasticityProtein IsoformsProtein Processing, Post-TranslationalRNA, MessengerSialic AcidsSialyltransferasesSynapsesConceptsNeural cell adhesion moleculePeriventricular areaIR-PSAPerineural spacePSA-NCAMCell adhesion moleculeAdhesion moleculesPSA-NCAM stainingExtent of stainingSialyltransferase mRNA levelsGonadotropin surgeNCAM stainingPreovulatory gonadotropinSynaptic plasticityProestrous afternoonEstrogenWestern blotProestrusIndividual neuronsRT-PCRMetestrusMRNA levelsHypothalamus tissueStainingSialyltransferase mRNA
2007
Expression of Mucins, SIMA, Villin, and CDX2 in Small-Intestinal Adenocarcinoma
Zhang MQ, Lin F, Hui P, Chen ZM, Ritter JH, Wang HL. Expression of Mucins, SIMA, Villin, and CDX2 in Small-Intestinal Adenocarcinoma. American Journal Of Clinical Pathology 2007, 128: 808-816. PMID: 17951204, DOI: 10.1309/jaf3kvgjhqcj1qf9.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCDX2 Transcription FactorFemaleFluorescent Antibody Technique, IndirectHomeodomain ProteinsHumansImmunoenzyme TechniquesIntestinal NeoplasmsIntestine, SmallMaleMicrofilament ProteinsMiddle AgedMucinsNeoplasm ProteinsConceptsSmall intestinal mucin antigenSmall intestinal adenocarcinomaColorectal adenocarcinomaFocal staining patternExpression of mucinsFrequency of expressionMucin antigenFocal stainingPositive stainingDiffuse immunoreactivityAdenocarcinomaDiffuse stainingStaining patternMUC5ACMUC1MUC2Morphologic similaritiesStainingCDX2ExpressionVillinImmunoreactivityAntigenBiomarkers
1999
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.
Whelan J, Dunbar P, Price D, Purbhoo M, Lechner F, Ogg G, Griffiths G, Phillips R, Cerundolo V, Sewell A. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. The Journal Of Immunology 1999, 163: 4342-8. PMID: 10510374, DOI: 10.4049/jimmunol.163.8.4342.Peer-Reviewed Original ResearchConceptsTetramer stainingPopulation of CTLTCR/peptide-MHC interactionCD8+ cellsPeptide-MHC class I complexesClass I ligandsPolyclonal cell populationsClass I complexesEarly endocytic compartmentEpitope variantsEffect of incubation temperatureImmune responseStaining intensityDegree of promiscuityI ligandsReceptor internalizationDegrees CCell populationsCTLEndocytic compartmentsStainingPeptide variantsConfocal microscopyWell-characterized setIncubation temperatureCloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus
Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceCarboxypeptidasesConsensus SequenceCosmidsEpithelial CellsFluorescent Antibody Technique, IndirectGenesHistocompatibility Antigens Class IIHumansIn Situ HybridizationLysosomesMajor Histocompatibility ComplexMiceMice, Inbred C57BLMolecular Sequence DataSequence AlignmentSequence Homology, Amino AcidSerine EndopeptidasesThymus GlandConceptsCortical thymic epithelial cellsAntigen-presenting cellsThymic epithelial cellsEpithelial cellsMHC class II presentationClass II antigen processingMHC class II antigen processingClass II presentationCortical epithelial cellsMajor histocompatibility complex regionThymic capsuleThymic cortexAntigen presentationT cellsSerine proteasesStrong stainingNovel MHCAntigen processingInvariant chainCathepsin SProteolytic milieuThymusPresentationSitu hybridizationStainingPolycystin-2 expression is developmentally regulated
Markowitz G, Cai Y, Li L, Wu G, Ward L, Somlo S, D’Agati V. Polycystin-2 expression is developmentally regulated. American Journal Of Physiology 1999, 277: f17-f25. PMID: 10409293, DOI: 10.1152/ajprenal.1999.277.1.f17.Peer-Reviewed Original ResearchConceptsPKD2 expressionMultiple mesenchymal tissuesLow-level stainingPostnatal day 14Low-intensity stainingRed blood cell precursorsPolycystin-2 expressionMultiple endocrine organsBlood cell precursorsAdrenal cortexEndocrine organDistal tubulesSmooth muscleProximal tubulesDay 14Day E12.5Adult patternBasolateral stainingCell precursorsMesenchymal tissueAdult kidneyOrgan-specific functionsEmbryonic dayStrong expressionStaining
1984
Glial fibrillary acidic protein in regenerating teleost spinal cord.
Anderson M, Swanson K, Waxman S, Eng L. Glial fibrillary acidic protein in regenerating teleost spinal cord. Journal Of Histochemistry & Cytochemistry 1984, 32: 1099-1106. PMID: 6481149, DOI: 10.1177/32.10.6481149.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinSpinal cordFibrillary acidic proteinRegenerated cordPositive stainingAcidic proteinPresence of GFAPTeleost spinal cordNeuronal cell bodiesRegeneration of neuritesGFAP stainingReactive astrocytesAstrocytic profilesNeuronal regenerationGoldfish brainAstrocytic processesCordCell bodiesUltrastructural studyGoldfish Carassius auratusStainingSternarchus albifronsBrainCarassius auratusAstrocytes
1982
Localization of Collagen Type IV in Basement Membranes by Monoclonal Antibodies
FOELLMER H, MADRI J, WYATT R, FURTHMAYR H. Localization of Collagen Type IV in Basement Membranes by Monoclonal Antibodies. Protides Of The Biological Fluids 1982, 29: 773-776. DOI: 10.1016/b978-0-08-027988-6.50180-4.Peer-Reviewed Original ResearchMonoclonal antibodiesType IV collagenBasement membraneType IVFrozen sectionsNormal human kidneyIV collagenSheep anti-rabbit IgGRabbit anti-mouse IgGBowman's capsuleCollagen type IVThick frozen sectionsHuman kidneyHuman placentaImmunofluorescence stainingAntibodiesKidneySpecific stainingSimilar labeling patternIgGMouse IgGAnti-rabbit IgGMouse EHS tumorStainingCollagen
1978
Intra-axonal ferric ion-ferrocyanide staining of nodes of Ranvier and initial segments in central myelinated fibers
Waxman S, Quick D. Intra-axonal ferric ion-ferrocyanide staining of nodes of Ranvier and initial segments in central myelinated fibers. Brain Research 1978, 144: 1-10. PMID: 76497, DOI: 10.1016/0006-8993(78)90430-4.Peer-Reviewed Original ResearchConceptsNodes of RanvierInitial segmentFerric ion-ferrocyanide stainingCentral nervous tissueAxon initial segmentCentral myelinated fibersSpinal cordMyelinated fibersNervous tissueMyelinated neuronsAxon hillockCell bodiesNodal axolemmaRanvierNeuronsAxolemmaStainingElectron-dense substanceStainInternodal regionsUltrastructural dataSpecialized regions
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