2025
Intraoperative frozen section diagnosis of lung specimens: An updated review
Han Y, Cai G. Intraoperative frozen section diagnosis of lung specimens: An updated review. Seminars In Diagnostic Pathology 2025, 42: 150901. PMID: 40188626, DOI: 10.1016/j.semdp.2025.150901.Peer-Reviewed Original ResearchConceptsIntraoperative FS diagnosisFS diagnosisImaging findingsFrozen sectionsIntraoperative frozen section diagnosisLung cancer screening strategiesMalignant-appearing lesionsClinical informationIntraoperative frozen sectionSurgical resection proceduresCancer screening strategiesCT imaging findingsHistological tumor classificationFrozen section diagnosisManagement of patientsDiagnosis of pulmonary nodulesLymphoproliferative disordersPreinvasive lesionsInvasive tumorsTumor entitiesIntraoperative diagnosisCellular atypiaResection proceduresMultiple nodulesPulmonary lesionsSoftware solution for integration of frozen section quality assurance into daily practice
Gibson J, Mutnick N, Gershkovich P, Sinard J. Software solution for integration of frozen section quality assurance into daily practice. American Journal Of Clinical Pathology 2025, 163: 794-802. PMID: 39838842, DOI: 10.1093/ajcp/aqae188.Peer-Reviewed Original ResearchPatient safetyImprove patient safetyQuality of careFS errorsClinical teamIncreased documentationSoftware solutionsSubspecialty expertisePathology facultyDaily practiceQuality assuranceShortened time intervalsCustom software solutionsInterventionReduce errorsResolution of errorsTechnical errorsCarePermanent diagnosisProgramFrozen sectionsPracticePhysical locationPathology laboratoryFaculty
2022
Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group
Dicken B, Billmire D, Rich B, Hazard F, Nuño M, Krailo M, Fallahazad N, Pashankar F, Shaikh F, Frazier A. Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group. Gynecologic Oncology 2022, 166: 476-480. PMID: 35750503, PMCID: PMC9514449, DOI: 10.1016/j.ygyno.2022.06.013.Peer-Reviewed Original ResearchConceptsIntra-operative frozen sectionOvarian germ cell tumorsGerm cell tumorsMalignant ovarian germ cell tumorsIntra-operative frozen section diagnosisFrozen section diagnosisCentral pathology reviewCell tumorsSurgical stagingAdolescent patientsFinal diagnosisFinal paraffin section diagnosisSection diagnosisFrozen sectionsParaffin section diagnosisOncology GroupPathology reviewCentral reviewOvarian germ cell malignanciesNonseminomatous germ cell tumorsGerm cell tumor componentsConfirmation of malignancyGerm cell malignanciesRecords of patientsChildren's Oncology GroupHeterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey
Ho S, Kuo E, Allende D, Wang HL, Westerhoff M, Graham RP, Saxena R, Gonzalez RS, Fiel MI, Yang Z, Zhang X, Liu X. Heterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey. Liver Transplantation 2022, 28: 1540-1542. PMID: 35377545, DOI: 10.1002/lt.26466.Peer-Reviewed Original Research
2018
Intra‐operative evaluation of prophylactic hysterectomy and salpingo‐oophorectomy specimens in hereditary gynaecological cancer syndromes
Wong S, Ratner E, Buza N. Intra‐operative evaluation of prophylactic hysterectomy and salpingo‐oophorectomy specimens in hereditary gynaecological cancer syndromes. Histopathology 2018, 73: 109-123. PMID: 29484698, DOI: 10.1111/his.13503.Peer-Reviewed Original ResearchConceptsIntra-operative evaluationTotal hysterectomyLynch syndromePermanent sectionsSalpingo-oophorectomy specimensFrozen section diagnosisGermline BRCA 1BrCa casesOccult malignancySurgical stagingProphylactic hysterectomyGynaecological malignanciesFinal diagnosisSecond surgeryGross findingsRetrospective analysisBRCA-1Cancer syndromesGross lesionsSection diagnosisDiagnostic discrepanciesFrozen sectionsMalignancyPractice recommendationsLS cases
2017
A Comparison between the Diagnostic Accuracy of Frozen Section and Permanent Section Analyses in Central Nervous System
Amraei R, Moradi A, Zham H, Ahadi M, Baikpour M, Rakhshan A. A Comparison between the Diagnostic Accuracy of Frozen Section and Permanent Section Analyses in Central Nervous System. Asian Pacific Journal Of Cancer Prevention 2017, 18: 659-666. PMID: 28440972, PMCID: PMC5464481, DOI: 10.22034/apjcp.2017.18.3.659.Peer-Reviewed Original ResearchCentral nervous system tumorsNervous system tumorsCentral nervous systemFrozen sectionsSystem tumorsNervous systemPermanent section analysisDescriptive retrospective studyIntra-operative diagnosisCNS surgeryCNS lesionsPathologic evaluationRadiologic findingsCNS tumorsRetrospective studyHistopathological evaluationClinical historyDefinite diagnosisMedical recordsPathology reportsDiagnostic acuityPosterior fossaTumor categoryMiddle fossaPatients
2016
Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract
Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang C, Matthaei H, Offerhaus G, Adham M, Bruno M, Reid M, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang K, Roa J, Allen P, Castillo C, Jang J, Klimstra D, Hruban R. Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract. Annals Of Surgery 2016, 263: 162-177. PMID: 25775066, PMCID: PMC4568174, DOI: 10.1097/sla.0000000000001173.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmTumoral intraepithelial neoplasmsIntraepithelial neoplasmMucinous neoplasmsHigher grades of dysplasiaGrade of dysplasiaEffective management algorithmsNon-invasive componentInternational multidisciplinary groupResected tumorTumor characteristicsInvasive carcinomaInvasive componentInvasive sizePathological evaluationImaging findingsPancreas groupRare casePancreatobiliary tractFrozen sectionsAccurate comparison of dataLesion sizeNeoplasmsDuct diameter
2015
Nipple‐sparing Mastectomy and Sub‐areolar Biopsy: To Freeze or not to Freeze? Evaluating the Role of Sub‐areolar Intraoperative Frozen Section
Alperovich M, Choi M, Karp NS, Singh B, Ayo D, Frey JD, Roses DF, Schnabel FR, Axelrod DM, Shapiro RL, Guth AA. Nipple‐sparing Mastectomy and Sub‐areolar Biopsy: To Freeze or not to Freeze? Evaluating the Role of Sub‐areolar Intraoperative Frozen Section. The Breast Journal 2015, 22: 18-23. PMID: 26510917, DOI: 10.1111/tbj.12517.Peer-Reviewed Original ResearchConceptsNipple-sparing mastectomyIntraoperative frozen sectionNipple-sparing mastectomiesNipple-areolar complexPermanent paraffin sectionsFrozen sectionsParaffin sectionsBreast cancer resectionRecords of patientsFrozen section resultsCancer resectionDuctal carcinomaProphylactic mastectomyResidual pathologyBreast reconstructionPermanent biopsyMastectomyBiopsyReconstructive planningSeparate proceduresResectionPatientsCarcinomaBreastCost Analysis of Intraoperative Subareolar Frozen Section During Nipple-Sparing Mastectomy
Alperovich M, Reis SM, Choi M, Karp NS, Frey JD, Chang JB, Axelrod DM, Shapiro RL, Guth AA. Cost Analysis of Intraoperative Subareolar Frozen Section During Nipple-Sparing Mastectomy. Annals Of Surgical Oncology 2015, 23: 490-493. PMID: 26438436, DOI: 10.1245/s10434-015-4882-8.Peer-Reviewed Original ResearchConceptsIntraoperative frozen sectionSubareolar biopsyNipple-areolar complexFrozen sectionsOperating roomNipple-sparing mastectomyOccult cancerOperative resectionHealthcare chargesPathology resultsBiopsyPatient recordsFirst cost analysisRoutine useEarly detectionInstitutional frequencyMastectomyBreastCost analysisFinancial chargesChallenges of Fertility Sparing Ovarian Surgery Imposed by Krukenberg Tumors in Pregnancy
Bloch MH, Elsarrag RZ, Elsarrag MZ, Salih SM. Challenges of Fertility Sparing Ovarian Surgery Imposed by Krukenberg Tumors in Pregnancy. Clinical Medical Reviews And Case Reports 2015, 2: 4. PMID: 26366440, PMCID: PMC4563814, DOI: 10.23937/2378-3656/1410041.Peer-Reviewed Original ResearchFertility sparing surgeryFrozen sectionsKrukenberg tumorSparing surgeryOvarian tumorsFertility-sparing surgeryFinal pathology examinationBorderline ovarian tumorsSteroid cell tumorReproductive-age womenIntraoperative frozen sectionOvarian stroma cellsLeft oophorectomyOvarian surgeryRight oophorectomyThird trimesterHormonal milieuCell tumorsPathology examinationSignet cellsSurgeryAccurate diagnosisStroma cellsTumorsPregnancyManagement of Borderline Ovarian Tumors Based on Patient and Tumor Characteristics
Black JD, Altwerger GH, Ratner E, Lu L, Silasi DA, Azodi M, Santin AD, Schwartz PE, Rutherford TJ. Management of Borderline Ovarian Tumors Based on Patient and Tumor Characteristics. Gynecologic And Obstetric Investigation 2015, 81: 169-173. PMID: 26067608, DOI: 10.1159/000431219.Peer-Reviewed Original ResearchMucinous tumorsSeromucinous tumorsOvarian tumorsComplete surgical stagingNormal-appearing appendixBorderline ovarian tumorsLymph node involvementRetrospective cohort analysisRisk of recurrenceAggressive stagingNodal diseaseSurgical stagingHazard ratioNode involvementDisease recurrencePseudomyxoma peritoneiSerous tumorsSingle institutionPathology reportsCohort analysisLower riskRecurrenceMultivariate analysisFrozen sectionsTumors
2009
Use Pre- and Intra-Operative Data To Predict Probability of Positive Non-Sentinel Lymph Nodes.
Chagpar A, Blumencranz P, Whitworth P, Deck K, Rosenberg A, Simmons R, Reintgen D, Beitsch P, Julian T, Saha S, Mamounas E, Giuliano A, Cook E, Wang S. Use Pre- and Intra-Operative Data To Predict Probability of Positive Non-Sentinel Lymph Nodes. Cancer Research 2009, 69: 302-302. DOI: 10.1158/0008-5472.sabcs-09-302.Peer-Reviewed Original ResearchAxillary node dissectionNon-SLN metastasisTumor sizeIntra-operative dataBLN AssayPositive SLNMedian numberLogistic regression modelsPositive non-sentinel lymph nodesSentinel lymph node-positive patientsCompletion axillary node dissectionFrozen sectionsLymph node-positive patientsNon-sentinel lymph nodesStepwise logistic regression modelFurther positive nodesNon-SLN statusMedian tumor sizeNode-positive patientsPositive rateTumor size dataSignificant predictorsCohort of interestNode dissectionPositive nodesMohs micrographic surgery histopathology concordance
Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-98. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.Peer-Reviewed Original Research
2004
Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation
Maygarden SJ, Detterbeck FC, Funkhouser WK. Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation. Modern Pathology 2004, 17: 1080-1086. PMID: 15133477, DOI: 10.1038/modpathol.3800154.Peer-Reviewed Original ResearchConceptsPositive marginsSite of tumorBronchial marginGross tumorFrozen sectionsWedge resectionCell carcinomaGross evaluationSalivary gland-type tumorsCentral lung tumorsPositive margin casesLung cancer resectionNonsmall cell carcinomaFrozen section evaluationSmall cell carcinomaFalse-negative casesTrue positive casesCancer resectionMucosal tumorsMargin positivityNegative marginsIntramucosal carcinomaTumor distanceUNC HospitalsLung tumors
2003
Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle
Takahashi W, Yono M, Wada Y, Ikeda K, Weiss R, Latifpour J. Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle. BJU International 2003, 92: 803-809. PMID: 14616470, DOI: 10.1046/j.1464-410x.2003.04466.x.Peer-Reviewed Original ResearchConceptsExpression of endothelinETB receptor subtypesET receptorsECE-1 mRNARat seminal vesicleReceptor subtypesSeminal vesiclesET-1Slide-mounted frozen sectionsET receptor systemET-3 mRNATotal ET receptorsETA receptor subtypeSprague-Dawley ratsReverse transcription-polymerase chain reactionExpression levelsExpression of ETAEffects of castrationEndothelin-converting enzymeMultiplex reverse transcription-polymerase chain reactionPolymerase chain reactionSmooth muscleET-3Autoradiographic studyFrozen sections
2001
Pancreatic Ductal Adenocarcinoma With Foamy Gland Pattern
Adsay V, Logani S, Klimstra D. Pancreatic Ductal Adenocarcinoma With Foamy Gland Pattern. Advances In Anatomic Pathology 2001, 6: 105-110. DOI: 10.1097/00132583-200105000-00005.Peer-Reviewed Original ResearchFoamy gland patternPale cytoplasmDiagnosis of metastatic tumorsDifferential diagnosis of metastatic tumorsGland patternPancreatic ductal adenocarcinomaMorphologically distinct variantLobular carcinomaMetastatic tumorsInfiltrative glandsMalignant glandsMucin markersPancreas cancerHepatoid patternIntraductal neoplasiaDifferential diagnosisDuctal adenocarcinomaIndian filesSized tubulesFrozen sectionsPancreatic ductalTumorColumnar cellsMicrovesicular componentsBrush border
1998
Coexpression of the HER-2 Gene Product, pl85HER-2, and Epidermal Growth Factor Receptor, pl70EGF-R, on Epithelial Ovarian Cancers and Normal Tissues
Bast R, Pusztai L, Kerns B, MacDonald J, Jordan P, Daly L, Boyer C, Mendelsohn J, Berchuck A. Coexpression of the HER-2 Gene Product, pl85HER-2, and Epidermal Growth Factor Receptor, pl70EGF-R, on Epithelial Ovarian Cancers and Normal Tissues. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1998, 17: 313-321. PMID: 9790065, DOI: 10.1089/hyb.1998.17.313.Peer-Reviewed Original ResearchConceptsOvarian cancerNormal ovarian epitheliumNormal tissuesOvarian epitheliumTumor cellsAdvanced ovarian cancerEpithelial ovarian cancerFavorable therapeutic indexCombination of antibodiesEpidermal growth factor receptorGrowth factor receptorEpithelial specimensHER-2Normal ovariesP170 expressionP185 expressionTherapeutic indexNeoplastic cellsTumor growthSynergistic cytotoxicityFrozen sectionsCancerTherapeutic activityDifferent antigensMonoclonal antibodiesInterleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cells
1996
Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.
Bacus SS, Chin D, Yarden Y, Zelnick CR, Stern DF. Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. American Journal Of Pathology 1996, 148: 549-58. PMID: 8579117, PMCID: PMC1861670.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsErbB ReceptorsFemaleFrozen SectionsGenes, erbB-2HumansImmunohistochemistryPhosphorylationPhosphotyrosinePrognosisProto-Oncogene MasReceptor Protein-Tyrosine KinasesReceptor, ErbB-2Receptor, ErbB-4Receptors, EstrogenReceptors, ProgesteroneReceptors, SteroidRetrospective StudiesConceptsMammary carcinomaReceptor tyrosine kinasesType 1 receptor tyrosine kinasesMammary carcinoma patientsType 1 receptorExpression of neuAnti-neu antibodyEpidermal growth factor receptorGrowth factor receptorTyrosine kinaseCarcinoma patientsPrognostic factorsPoor prognosisClinical evaluationTherapeutic strategiesCarcinomaHER-4Frozen sectionsSteroid receptorsNeu/ErbBNeuFactor receptorReceptorsDifferent biological activitiesTyrosine phosphorylation
1992
Monoclonal antibodies to malignant human gliomas
Wikstrand C, Fredman P, Svennerholm L, Humphrey P, Bigner S, Bigner D. Monoclonal antibodies to malignant human gliomas. Journal Of Molecular Neuroscience 1992, 17: 137-146. PMID: 1384525, DOI: 10.1007/bf03159988.Peer-Reviewed Original ResearchConceptsPrimary CNS neoplasmsCNS neoplasmsHuman gliomasMonoclonal antibodiesMalignant brain tumorsHuman glioma xenograftsMalignant human gliomasAdult human brainNormal adult tissuesMAb localizationSpecific monoclonal antibodiesGlioma xenograftsBrain tumorsCytologic specimensFrozen sectionsEpitopic specificityGlioma biopsiesEGFR geneNeoplasmsGliomasVivo diagnosisMutant EGFREGFR proteinAntibodiesTumors
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